Genome-wide association studies have struggled to identify functional genes and variants
underlying complex phenotypes. We recruited a multi-ethnic cohort of healthy volunteers (n = …

Establishment of a physiologically relevant human hepatocyte‐like cell system for in vitro
translational research has been hampered by the limited availability of cell models that …

Hepatocytes store triglycerides (TGs) in the form of lipid droplets (LDs), which are increased
in hepatosteatosis. The regulation of hepatic LDs is poorly understood and new therapies to …

Pathogenic mutations in LAMIN A/C (LMNA) cause abnormal nuclear structure and
laminopathies. These diseases have myriad tissue-specific phenotypes, including dilated …

Background and Aims NASH will soon become the leading cause of liver transplantation in
the United States and is also associated with increased COVID‐19 mortality. Currently, there …

Genome-wide association studies have identified a signal at the SLC22A1 locus for serum
acylcarnitines, intermediate metabolites of mitochondrial oxidation whose plasma levels …

Embryonic stem cells (ES-cells) provide a good model system to study lineage-specific
differentiation. Though, the differentiation of ES-cells to cardiomyocytes is documented, a clear …

Stem cells in cell based therapy for cardiac injury is being potentially considered. However,
genetic regulatory networks involved in cardiac differentiation are not clearly understood. …

Recent advances in self-organizing, 3-dimensional tissue cultures of embryonic stem cells (ESCs)
and induced pluripotent stem cells (iPSCs) provided an in vitro model that …

Pluripotent stem cells (PSCs) are specialized cells, which have remarkable ability to maintain
in an undifferentiated state and are capable of undergoing differentiation to three germ-…