MicroRNAs (miRNAs) are a class of small noncoding RNAs that have gained status as
important regulators of gene expression. Here, we investigated the function and molecular …

Cardiovascular disease is the leading cause of human morbidity and mortality. Dilated
cardiomyopathy (DCM) is the most common form of cardiomyopathy associated with heart failure. …

Paradigm-shifting studies in the mouse have identified tissue macrophage heterogeneity as
a critical determinant of immune responses. In contrast, surprisingly little is known regarding …

Background : Data for left ventricular assist devices (LVADs) in patients with noninotrope-dependent
heart failure (HF) are limited. Objectives : The goal of this study was to evaluate …

Despite years of experimental and clinical research, myocardial ischemia-reperfusion (IR)
remains an important cause of cardiac morbidity and mortality. The transcription factor nuclear …

Objective: Because isolated common iliac artery aneurysms are infrequent, are difficult to
detect and treat, and have traditionally been associated with high operative mortality rates in …

An elevated level of C-reactive protein (CRP), an acute phase protein, is one of many downstream
indicators of inflammation. Physiologically, CRP enhances cell-mediated immunity by …

We previously reported the importance of the serum response factor (SRF) cofactor
myocardin in controlling muscle gene expression as well as the fundamental role for the …

Background— Bleeding is an important cause of morbidity and mortality in patients with
continuous-flow left ventricular assist devices (LVADs). Reduced pulsatility has been implicated …

Objectives : The authors sought to provide the pre-specified primary endpoint of the ROADMAP
(Risk Assessment and Comparative Effectiveness of Left Ventricular Assist Device and …