Helicobacter pylori colonizes half of the global population and causes gastritis, peptic ulcer
disease or gastric cancer. In this study, we were interested in human annexin (ANX), which …

Type IV secretion of effector proteins is an important principle for interaction of human
pathogens with their target cells. The corresponding secretion systems may transport a multitude …

We describe a drug-repurposing treatment involving the use of nicardipine in a young patient
with Pitt-Hopkins syndrome (a rare neurodevelopmental disorder that results from variants …

Respiratory complex I is a multicomponent enzyme conserved between eukaryotic cells and
many bacteria, which couples oxidation of electron donors and quinone reduction with …

The bacterial human pathogen Helicobacter pylori produces a type IV secretion system (cagT4SS)
to inject the oncoprotein CagA into gastric cells. The cagT4SS external pilus mediates …

Heavy metal and metalloid contaminations are among the most concerning types of pollutant
in the environment. Consequently, it is important to investigate the molecular mechanisms …

Type IV secretion systems are protein secretion machineries that are frequently used by
pathogenic bacteria to inject their virulence factors into target cells of their respective hosts. In …

The production of anti-Zika virus (ZIKV) therapeutics has become increasingly important as
the propagation of the devastating virus continues largely unchecked. Notably, a causal …

Helicobacter pylori displays a worldwide infection rate of about 50%. The Gram‐negative
bacterium is the main reason for gastric cancer and other severe diseases. Despite …

A library of over 103 thousand compounds was screened for inhibitors of the IspD domain (2‐C‐methyl‐d‐erythritol
4‐phosphate cytidylyl transferase domain) of the bifunctional IspDF …