Macroautophagic clearance of cytosolic materials entails the initiation, growth and closure
of autophagosomes. Cargo triggers the assembly of a web of cargo receptors and core …

Shuttling of macromolecules between different cellular compartments helps regulate the
timing and extent of different cellular activities. Here, we report that LC3, a key initiator of …

Eukaryotes initiate autophagy to cope with the lack of external nutrients, which requires the
activation of the nicotinamide adenine dinucleotide (NAD + )-dependent deacetylase Sirtuin …

Deficiency in autophagy, a lysosome-dependent cell degradation pathway, has been
associated with a variety of diseases especially cancer. Recently, the activation of autophagy by …

Despite recent advances in understanding the functions of autophagy in developmental and
pathological conditions, the underlying mechanism of where and how autophagosomal …

Continuous turnover of intracellular components by autophagy is necessary to preserve
cellular homeostasis in all tissues. Despite recent advances in identifying autophagy-related …

Autophagy degrades cytoplasmic cargo by its delivery to lysosomes within double membrane
autophagosomes. Synthesis of the phosphoinositide PI(3)P by the autophagic class III …

Membrane targeting of the BECN1-containing class III PI 3-kinase (PI3KC3) complexes is
pivotal to the regulation of autophagy. The interaction of PI3KC3 complex II and its ubiquitously …

Selective autophagy of damaged mitochondria, protein aggregates, and other cargoes is
essential for health. Cargo initiates phagophore biogenesis, which entails the conjugation of …

The selective autophagy pathways of xenophagy and mitophagy are initiated when the adaptor
NDP52 recruits the ULK1 complex to autophagic cargo. Hydrogen-deuterium exchange …