The female reproductive tract harbors distinct microbial communities, as in the vagina, cervical
canal, uterus, and fallopian tubes. The nature of the vaginal microbiota is well-known; in …

A single-chain fragment variable (scFv) recognizing β2-glycoprotein 1 (β2GPI) from humans
and other species was isolated from a human phage display library and engineered to …

In vitro studies have documented β2 glycoprotein I (β2GPI) binding to endothelial cells (ECs)
and trophoblast using antiphospholipid antibodies. The in vivo binding of β2GPI to these …

Fetal trophoblast cells invading the decidua in the early phase of pregnancy establish
complex interaction with the maternal extracellular matrix. We discovered that C1q was widely …

Endometriosis (EM) is a chronic disease characterized by the presence and proliferation of
functional endometrial glands and stroma outside the uterine cavity. Ovaries and pelvic …

During early pregnancy, uterine mucosa decidualization is accompanied by a drastic
enrichment of CD56 high CD16 − natural killer (NK) cells. Decidual NK (dNK) cells differ from …

Complement C1q is the activator of the classical pathway. However, it is now recognized
that C1q can exert functions unrelated to complement activation. Here we show that C1q, but …

Fetal loss in animals and humans is frequently associated with inflammatory conditions. D6
is a promiscuous chemokine receptor with decoy function, expressed in lymphatic …

We have previously shown that C1q is expressed on endothelial cells (ECs) of newly formed
decidual tissue. Here we demonstrate that C1q is deposited in wound-healing skin in the …

COVID-19 is characterized by virus-induced injury leading to multi-organ failure, together
with inflammatory reaction, endothelial cell (EC) injury, and prothrombotic coagulopathy with …