The β-haemoglobinopathies are the most prevalent inherited disorders worldwide. Gene
therapy of β-thalassaemia is particularly challenging given the requirement for massive …

The MYC proto-oncogene encodes a ubiquitous transcription factor (c–MYC) involved in the
control of cell proliferation and differentiation 1. Deregulated expression of c–MYC caused …

The protein encoded by the c-MYC proto-oncogene is a transcription factor that can both
activate and repress the expression of target genes, but few of its transcriptional targets have …

The proto-oncogene c-myc (myc) encodes a transcription factor (Myc) that promotes growth,
proliferation and apoptosis. Myc has been suggested to induce these effects by induction/…

The c-Myc protein (Myc) is a transcription factor, and deregulated expression of the c-myc
gene (myc) is frequently found in tumours. In Burkitt's lymphoma (BL), myc is transcriptionally …

The product of the proto‐oncogene c‐myc (myc) is a potent activator of cell proliferation. In
Burkitt lymphoma (BL), a human B‐cell tumor, myc is consistently found to be transcriptionally …

Chromosomal translocations juxtaposing the MYC protooncogene with regulatory sequences
of immunoglobulin (Ig) H chain or kappa (Igκ) or lambda (Igλ) L chain genes and effecting …

To characterize the effects of inhibitors of Epstein‐Barr virus (EBV) reactivation, we established
Raji DR‐LUC cells as a new test system. These cells contain the firefly luciferase (LUC) …

Lymphoblastoid cell lines, generated by immortalization of normal B cells by Epstein–Barr
virus (EBV) in vitro, have strong antigen-presenting capacity, are sensitive to EBV-specific …

The Epstein–Barr virus (EBV)-encoded latent membrane protein-1 induces NF-κB activity by
targeting IκBα. To understand the role of NF-κB activation in EBV-related oncogenesis, we …