Highly pathogenic H5N1 influenza A viruses have spread relentlessly across the globe since
2003, and they are associated with widespread death in poultry, substantial economic loss …

Background Coronaviruses pose a serious threat to global health as evidenced by Severe
Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and COVID…

We have demonstrated previously that local, adenoviral-mediated gene transfer of viral IL-10
to a single joint of rabbits and mice with experimental arthritis can suppress disease in both …

Dendritic cells (DC) can readily capture Ag from dead and dying cells for presentation to
MHC class I-restricted CTL. We now show by using a primate model that DC also acquire Ag …

The causative agent of severe acute respiratory syndrome (SARS) has been identified as a
new type of coronavirus. Here, we have investigated the ability of adenoviral delivery of …

One of the major limitations of the use of adenoviruses as gene therapy vectors is the
existence of preformed immunity in various populations. Recent studies have linked failure of …

The recent emergence of highly pathogenic avian influenza virus (HPAI) strains in poultry
and their subsequent transmission to humans in Southeast Asia have raised concerns about …

We have recently reported the identification of four novel members of the interleukin-1 (IL-1)
family which we designated as IL-1 homologue 1–4 (IL-1H1–4). These proteins exhibit …

The liver is an important site of host-microbe interaction. Although hepatocytes have been
reported to be responsive to lipopolysaccharide (LPS), the global gene expression changes …

The backbone of ovarian cancer treatment is platinum-based chemotherapy and aggressive
surgical debulking. New therapeutic approaches using immunotherapy via immune …