The integrated stress response (ISR) is a conserved pathway in eukaryotic cells that is
activated in response to multiple sources of cellular stress. Although acute activation of this …

Background: Onychomycosis is a common fungal infection of the nail. Objective: The study
aimed to provide an update on the evaluation, diagnosis, and treatment of onychomycosis. …

Simple Summary Germline mutation rates and spectra across three cohorts of Chinese
patients: a high-risk breast cancer cohort, an unselected breast cancer cohort, and a benign …

Familial transthyretin amyloidosis (ATTR) is an autosomal-dominant protein-folding disorder
caused by over 100 distinct mutations in the transthyretin (TTR) gene. In ATTR, protein …

Significance: Diabetes is associated with markedly accelerated rates of micro- and
macrovascular complications that increase morbidity and mortality. Understanding the molecular …

Endogenous retroviruses (ERVs) are ancient viral elements that have accumulated in the
genome through retrotransposition events. Although they have lost their ability to transpose, …

Repeated administration of meloxicam can cause kidney damage in cats by mechanisms that
remain unclear. Metabolomics and lipidomics are powerful, noninvasive approaches used …

Objective To examine the surgical and pathologic findings of 15 patients who had initially
unresectable hepatocellular carcinoma (HCC) and received preoperative systemic …

… Kong, and Elmo Chan, MECP, Yang Memorial Methodist Social Service, Hong Kong, in
supporting the parent-child interaction program development and implementation and Amy …

Background Diabetes outcomes are influenced by host factors, settings, and care processes.
We examined the association of data-driven integrated care assisted by information and …