User profiles for Adrian-Bogdan Tigu

Tigu Adrian Bogdan

MedFuture Research Center for Advanced Medicine, “Iuliu Hatieganu” UMPh, Cluj-Napoca …
Verified email at umfcluj.ro
Cited by 800

An emerging class of long non-coding RNA with oncogenic role arises from the snoRNA host genes

AA Zimta, AB Tigu, C Braicu, C Stefan, C Ionescu… - Frontiers in …, 2020 - frontiersin.org
The small nucleolar RNA host genes (SNHGs) are a group of long non-coding RNAs, which
are reported in many studies as being overexpressed in various cancers. With very few …

Molecular links between central obesity and breast cancer

AA Zimta, AB Tigu, M Muntean, D Cenariu… - International journal of …, 2019 - mdpi.com
Worldwide, breast cancer (BC) is the most common malignancy in women, in regard to
incidence and mortality. In recent years, the negative role of obesity during BC development and …

Therapeutic advances of targeting receptor tyrosine kinases in cancer

C Tomuleasa, AB Tigu, R Munteanu… - … and Targeted Therapy, 2024 - nature.com
Receptor tyrosine kinases (RTKs), a category of transmembrane receptors, have gained
significant clinical attention in oncology due to their central role in cancer pathogenesis. Genetic …

The role of epigenetic modifier mutations in peripheral T-cell lymphomas

AB Tigu, A Bancos - Current Issues in Molecular Biology, 2023 - mdpi.com
Peripheral T-cell lymphomas (PTCLs) are a group of diseases with a low incidence, high
degree of heterogeneity, and a dismal prognosis in most cases. Because of the low incidence …

Design and preclinical testing of an anti‐CD41 CAR T cell for the treatment of acute megakaryoblastic leukaemia

AB Tigu, CS Constantinescu… - Journal of Cellular …, 2023 - Wiley Online Library
Adrian Bogdan Tigu and Catalin Constantinescu contributed equally to the current manuscript.
Catalin Constantinescu is funded by an internal grant of the Iuliu Hatieganu University – …

Nanoscale delivery systems for microRNAs in cancer therapy

…, D Gulei, AA Zimta, A Onaciu, L Magdo, AB Tigu… - Cellular and Molecular …, 2020 - Springer
Concomitant with advances in research regarding the role of miRNAs in sustaining
carcinogenesis, major concerns about their delivery options for anticancer therapies have been …

Natural compounds modulate the crosstalk between apoptosis-and autophagy-regulated signaling pathways: Controlling the uncontrolled expansion of tumor cells

C Braicu, O Zanoaga, AA Zimta, AB Tigu… - Seminars in Cancer …, 2022 - Elsevier
Due to the high number of annual cancer–related deaths, and the economic burden that this
malignancy affects today’s society, the study of compounds isolated from natural sources …

Phytochemical Analysis and In Vitro Effects of Allium fistulosum L. and Allium sativum L. Extracts on Human Normal and Tumor Cell Lines: A Comparative Study

AB Țigu, CS Moldovan, VA Toma, AD Farcaș, AC Moț… - Molecules, 2021 - mdpi.com
Allium sativum L. (garlic bulbs) and Allium fistulosum L. (Welsh onion leaves) showed
quantitative differences of identified compounds: allicin and alliin (380 µg/mL and 1410 µg/mL in …

Inhibitory effect of CAPE and kaempferol in colon cancer cell lines—possible implications in new therapeutic strategies

…, A Barbat, A Moldovan, C Moldovan, AB Tigu… - International journal of …, 2019 - mdpi.com
Background: Phytochemicals are natural compounds synthesized as secondary metabolites
in plants and represent an important source of molecules with therapeutic applications. …

The synergistic antitumor effect of 5-fluorouracil combined with allicin against lung and colorectal carcinoma cells

AB Țigu, VA Toma, AC Moț, A Jurj, CS Moldovan… - Molecules, 2020 - mdpi.com
5-fluorouracil (5-FU) is an anticancer drug used to inhibit the proliferation of many different
tumor cells. Since severe events are associated with this compound, its combination with …