Hubel and Wiesel began the modern study of development and plasticity of primary visual
cortex (V1), discovering response properties of cortical neurons that distinguished them from …

Abnormalities in brain development, thought to be irreversible in adults, have long been
assumed to underlie the neurological and psychiatric symptoms associated with …

Background Alterations in neural excitation and inhibition cause a number of neurologic and
psychiatric disorders. In the cerebral cortex, excitation and inhibition are mediated by two …

An activity-dependent form of synaptic plasticity underlies the fine tuning of connections in
the developing primary visual cortex of mammals such as the cat and monkey. Studies of the …

The cortical representations of the hand in area 3b in adult owl monkeys were defined with
use of microelectrode mapping techniques 2–8 months after surgical amputation of digit 3 …

If vision in one eye is blurred or occluded during a critical period in postnatal development,
neurons in the visual cortex lose their responses to stimulation through that eye within a few …

Studies of visual processing in rodents have conventionally been performed on
anesthetized animals, precluding examination of the effects of behavior on visually evoked …

Genetic methods available in mice are likely to be powerful tools in dissecting cortical
circuits. However, the visual cortex, in which sensory coding has been most thoroughly …

Sensory experience in early life shapes the mammalian brain. An impairment in the activity-
dependent refinement of functional connections within developing visual cortex was …

The brain's response to sensory input is strikingly modulated by behavioral state. Notably,
the visual response of mouse primary visual cortex (V1) is enhanced by locomotion, a …