The extracellular environment is largely comprised of complex polysaccharides, which were
historically considered inert materials that hydrated the cells and contributed to the structural …

Cell-surface/extracellular-matrix heparan-sulphate glycosaminoglycans (HSGAGs) are
complex polysaccharides that are ubiquitous in nature, and that regulate several aspects of …

Extracellular modulation of phenotype is an emerging paradigm in this current postgenomics
age of molecular and cell biology. Glycosaminoglycans (GAGs) are primary components of …

In the continuing search for effective treatments for cancer, the emerging model is the
combination of traditional chemotherapy with anti-angiogenesis agents that inhibit blood …

A switch in specificity of avian influenza A viruses' hemagglutinin (HA) from avian-like (α2-3
sialylated glycans) to human-like (α2-6 sialylated glycans) receptors is believed to be …

Recent reports of mild to severe influenza-like illness in humans caused by a novel swine-
origin 2009 A (H1N1) influenza virus underscore the need to better understand the …

Recently, certain lots of heparin have been associated with an acute, rapid onset of serious
side effects indicative of an allergic-type reaction. To identify potential causes for this sudden …

In comparison with genomics and proteomics, the advancement of glycomics has faced
unique challenges in the pursuit of developing analytical and biochemical tools and …

Background There is an urgent need to determine whether oversulfated chondroitin sulfate
(OSCS), a compound contaminating heparin supplies worldwide, is the cause of the severe …

Rapid antigenic evolution in the influenza A virus hemagglutinin precludes effective
vaccination with existing vaccines. To understand this phenomenon, we passaged virus in …