NMDA-type glutamate receptors (NMDARs) mediate many forms of synaptic plasticity. These
tetrameric receptors consist of two obligatory NR1 subunits and two regulatory subunits …

Angelman syndrome (AS) is a severe genetic disorder caused by mutations or deletions of
the maternally inherited UBE3A gene. UBE3A encodes an E3 ubiquitin ligase that is …

Various combinations of subunits assemble to form the NMDA-type glutamate receptor
(NMDAR), generating diversity in its functions. Here we review roles of the unique NMDAR …

The receptive fields of visual cortical neurons are bidirectionally modified by sensory
deprivation and experience, but the synaptic basis for these changes is unknown. Here we …

Light deprivation lowers the threshold for long-term depression (LTD) and long-term
potentiation (LTP) in visual cortex by a process termed metaplasticity, but the mechanism is …

Angelman syndrome is a severe neurodevelopmental disorder caused by deletion or
mutation of the maternal allele of the ubiquitin protein ligase E3A (UBE3A),,. In neurons, the …

Experience-dependent maturation of neocortical circuits is required for normal sensory and
cognitive abilities, which are distorted in neurodevelopmental disorders. We tested whether …

Sensory experience is crucial in the refinement of synaptic connections in the brain during
development. It has been suggested that some forms of experience-dependent synaptic …

During neuronal activity, extracellular potassium concentration ([K+] out) becomes elevated
and, if uncorrected, causes neuronal depolarization, hyperexcitability, and seizures …

Activation of group 1 metabotropic glutamate receptors (mGluRs) stimulates dendritic protein
synthesis and long-term synaptic depression (LTD), but it remains unclear how these effects …