Strong evidence indicates that regulated mRNA translation in neuronal dendrites underlies
synaptic plasticity and brain development. The fragile X mental retardation protein (FMRP) is …

Memories are thought to be sparsely encoded in neuronal networks, but little is known about
why a given neuron is recruited or allocated to a particular memory trace. Previous research …

Fragile X syndrome (FXS) results from the loss of the fragile X mental retardation protein
(FMRP), an RNA-binding protein that regulates a variety of cytoplasmic mRNAs. FMRP …

Collections of cells called engrams are thought to represent memories. Although there has
been progress in identifying and manipulating single engrams, little is known about how …

Unraveling the mechanisms by which the molecular manipulation of genes of interest
enhances cognitive function is important to establish genetic therapies for cognitive …

BACKGROUND: Structural and functional neuroimaging studies suggest abnormal activity in
the striatum of patients with the fragile X syndrome (FXS), the most common form of inherited …

The dentate gyrus (DG) is important for encoding contextual memories, but little is known
about how a population of DG neurons comes to encode and support a particular memory …

The formation of long-lasting memories requires coordinated changes in gene expression
and protein synthesis. Although many studies implicate DNA modifications (DNA …

Memory formation is thought to be mediated by dendritic-spine growth and restructuring.
Myocyte enhancer factor 2 (MEF2) restricts spine growth in vitro, suggesting that this …

Memory stabilization following encoding (synaptic consolidation) or memory reactivation
(reconsolidation) requires gene expression and protein synthesis (;;;). Although …