The discovery of cannabinoid receptors and subsequent identification of their endogenous
ligands (endocannabinoids) in early 1990s have greatly accelerated research on …

Functional neural circuit formation during postnatal development involves the elimination of
early-formed redundant synapses. In the neonatal mouse cerebellum, each Purkinje cell is …

Since the first reports in 2001, great advances have been made towards the understanding
of endocannabinoid-mediated synaptic modulation. Electrophysiological studies have …

Abstract MicroRNAs (miRNAs), noncoding RNAs 21–25 nucleotides in length, regulate gene
expression primarily at the posttranscriptional level. Growing evidence suggests that …

Endocannabinoids are released from postsynaptic neurons and cause retrograde
suppression of synaptic transmission. Anandamide and 2-arachidonoylglycerol (2-AG) are …

PKCy is highly expressed in Purkinje cells (PCs) but not in other types of neurons in the
cerebellum. The expression of PKCy changes markedly during cerebellar development …

Combined stimulation with VEGF-A, FGF-2, or PDGF-BB has emerged as a potent strategy
for therapeutic angiogenesis, although the mechanisms underlying the synergism of these …

A major goal in cancer research is to develop carriers that can deliver drugs effectively and
without side effects. Liposomal and particulate carriers with diameters of∼ 100 nm have …

Transforming growth factor (TGF)-β plays a pivotal role in regulation of progression of cancer
through effects on tumor microenvironment as well as on cancer cells. TGF-β inhibitors have …

Endogenous cannabinoids are considered to function as diffusible and short-lived
modulators that may transmit signals retrogradely from postsynaptic to presynaptic neurons …