Rapid induction of type I interferon (IFN) expression is a central event in the establishment of
the innate immune response against viral infection and requires the activation of multiple …

The type I interferon (IFN) α and β promoters have been a leading paradigm of virus-
activated transcriptional regulation for more than two decades, and have contributed …

Viral and microbial constituents contain specific motifs or pathogen-associated molecular
patterns (PAMPs) that are recognized by cell surface-and endosome-associated Toll-like …

Rapid induction of type I interferon expression, a central event in establishing the innate
antiviral response, requires cooperative activation of numerous transcription factors …

The-300 region of the interleukin 1β (IL-1β) promoter contains a functional NF-κB binding
site composed of the decamer sequence 5'-GGGAAAATCC-3'. Probes representing the-300 …

The interferon regulatory factors (IRF) consist of a growing family of related transcription
proteins first identified as regulators of the alpha beta interferon (IFN-α/β) gene promoters …

Ubiquitously expressed interferon regulatory factor 3 (IRF-3) is directly activated after virus
infection and functions as a key activator of the immediate-early alpha/beta interferon (IFN) …

Ideally, an oncolytic virus will replicate preferentially in malignant cells, have the ability to
treat disseminated metastases, and ultimately be cleared by the patient. Here we present …

Interferons are a large family of multifunctional secreted proteins involved in antiviral
defense, cell growth regulation and immune activation. Viral infection induces transcription …

The induction of interferon (IFN) genes by viruses or double-stranded RNA (dsRNA)
requires the assembly of a complex set of transcription factors on responsive DNA elements …