Since its initial conceptualisation, metaplasticity has come to encompass a wide variety of
phenomena and mechanisms, creating the important challenge of understanding how they …

Synaptic plasticity is fundamental to the neural processes underlying learning and memory.
Interestingly, synaptic plasticity itself can be dynamically regulated by prior activity, in a …

The Bienenstock, Cooper and Munro (BCM) computational model, which incorporates a
metaplastic sliding threshold for LTP induction, accounts well for experience-dependent …

Activation of Group I metabotropic glutamate receptors (mGluRs) in rat hippocampus
induces a form of long-term depression (LTD) that is dependent on protein synthesis …

The term synaptic plasticity describes the ability of excitatory synapses to undergo activity-
driven long-lasting changes in the efficacy of basal synaptic transmission. This change may …

The release of glutamine from astrocytes adjacent to synapses in the central nervous system
is thought to play a vital role in the mechanism of glutamate recycling and is therefore …

Synaptic plasticity is subject to activity-dependent long-term modification (metaplasticity). We
have recently described a novel form of heterosynaptic metaplasticity in hippocampal CA1 …

Astrocytes are glial cells that have an intimate physical and functional association with
synapses in the brain. One of their main roles is to recycle the neurotransmitters glutamate …

Thalamocortical neurons integrate sensory and cortical activity and are regulated by input
from inhibitory neurons in the thalamic reticular nucleus. Evidence suggests that during …