Type I diabetes mellitus is caused by an autoimmune destruction of the insulin‐producing β
cells. The major obstacle in using transplantation for curing the disease is the limited source …

The study of human cardiac tissue development is hampered by the lack of a suitable in vitro
model. We describe the phenotypic properties of cardiomyocytes derived from human …

Human embryonic stem (hES) cells hold great promise for future use in various research
areas, such as human developmental biology and cell-based therapies. Traditionally, these …

T cells, particularly CD 4+ T cells, play a central role in both progression and control of
periodontal disease, whereas the contribution of the various CD 4+ T helper subsets to …

Langerhans cells (LCs) populate the mucosal epithelium, a major entry portal for pathogens,
yet their ontogeny remains unclear. We found that, in contrast to skin LCs originating from …

Excessive bone resorption is frequently associated with chronic infections and inflammatory
diseases. Whereas T cells were demonstrated to facilitate osteoclastogenesis in such …

During early embryogenesis, the cardiovascular system is the first system to be established
and is initiated by a process involving the hypoblastic cells of the primitive endoderm …

Induced pluripotent stem cells (iPSCs) represent an ideal cell source for future cell therapy
and regenerative medicine. However, most iPSC lines described to date have been isolated …

We have developed a technique to precisely isolate and process murine gingival tissue for
flow cytometry and molecular studies. The gingiva is a unique and important tissue to study …

Whereas type I interferons (IFNs-I) were proposed to be elevated in human periodontitis,
their role in the disease remains elusive. Using a bacterial-induced model of murine …