The severe acute respiratory syndrome (SARS), caused by a novel coronavirus (SARS-
CoV), resulted in substantial morbidity, mortality, and economic losses during the 2003 …

Studies of patients with severe acute respiratory syndrome (SARS) demonstrate that the
respiratory tract is a major site of SARS-coronavirus (CoV) infection and disease morbidity …

Almost two decades after CFTR was identified as the gene responsible for cystic fibrosis
(CF), we still lack answers to many questions about the pathogenesis of the disease, and it …

The ongoing coronavirus disease 2019 (COVID-19) pandemic is associated with substantial
morbidity and mortality. Although much has been learned in the first few months of the …

Cystic fibrosis (CF) is a life-shortening disease caused by mutations in the cystic fibrosis
transmembrane conductance regulator (CFTR) gene. Although bacterial lung infection and …

Middle East respiratory syndrome coronavirus (MERS-CoV) causes life-threatening disease.
Dipeptidyl peptidase 4 (DPP4) is the receptor for cell binding and entry. There is a need for …

Lung disease causes most of the morbidity and mortality in cystic fibrosis (CF).
Understanding the pathogenesis of this disease has been hindered, however, by the lack of …

In this era of continued emergence of zoonotic virus infections, the rapid development of
rodent models represents a critical barrier to public health preparedness, including the …

Angiotensin-converting enzyme 2 (ACE2) is a terminal carboxypeptidase and the receptor
for the SARS and NL63 coronaviruses (CoV). Loss of ACE2 function is implicated in severe …

Type 1 IFNs (IFN-I) generally protect mammalian hosts from virus infections, but in some
cases, IFN-I is pathogenic. Because IFN-I is protective, it is commonly used to treat virus …