The selection and function of cell type-specific enhancers
The human body contains several hundred cell types, all of which share the same genome.
In metazoans, much of the regulatory code that drives cell type-specific gene expression is …
In metazoans, much of the regulatory code that drives cell type-specific gene expression is …
Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
Genome-scale studies have revealed extensive, cell type-specific colocalization of
transcription factors, but the mechanisms underlying this phenomenon remain poorly …
transcription factors, but the mechanisms underlying this phenomenon remain poorly …
[HTML][HTML] Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription
Recent studies suggest a hierarchical model in which lineage-determining factors act in a
collaborative manner to select and prime cell-specific enhancers, thereby enabling signal …
collaborative manner to select and prime cell-specific enhancers, thereby enabling signal …
Metascape provides a biologist-oriented resource for the analysis of systems-level datasets
…, AH Khodabakhshi, O Tanaseichuk, C Benner… - Nature …, 2019 - nature.com
A critical component in the interpretation of systems-level studies is the inference of enriched
biological pathways and protein complexes contained within OMICs datasets. Successful …
biological pathways and protein complexes contained within OMICs datasets. Successful …
FINEMAP: efficient variable selection using summary data from genome-wide association studies
Motivation: The goal of fine-mapping in genomic regions associated with complex diseases
and traits is to identify causal variants that point to molecular mechanisms behind the …
and traits is to identify causal variants that point to molecular mechanisms behind the …
Exome sequencing and analysis of 454,787 UK Biobank participants
A major goal in human genetics is to use natural variation to understand the phenotypic
consequences of altering each protein-coding gene in the genome. Here we used exome …
consequences of altering each protein-coding gene in the genome. Here we used exome …
Transcription elongation can affect genome 3D structure
How transcription affects genome 3D organization is not well understood. We found that
during influenza A (IAV) infection, rampant transcription rapidly reorganizes host cell …
during influenza A (IAV) infection, rampant transcription rapidly reorganizes host cell …
Plasma proteomic associations with genetics and health in the UK Biobank
Abstract The Pharma Proteomics Project is a precompetitive biopharmaceutical consortium
characterizing the plasma proteomic profiles of 54,219 UK Biobank participants. Here we …
characterizing the plasma proteomic profiles of 54,219 UK Biobank participants. Here we …
Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA
Mammalian genomes are populated with thousands of transcriptional enhancers that
orchestrate cell-type-specific gene expression programs,,,, but how those enhancers are …
orchestrate cell-type-specific gene expression programs,,,, but how those enhancers are …
Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis
…, D Scholten, C Jiang, C Benner… - Proceedings of the …, 2012 - National Acad Sciences
Myofibroblasts produce the fibrous scar in hepatic fibrosis. In the carbon tetrachloride (CCl4)
model of liver fibrosis, quiescent hepatic stellate cells (HSC) are activated to become …
model of liver fibrosis, quiescent hepatic stellate cells (HSC) are activated to become …
