In thi paper, we review experimental evidence for a novel form of persistent synaptic
plasticity we call metaplasticity. Metaplasticity is induced by synaptic or cellular activity, but it …

Synaptic plasticity is a key component of the learning machinery in the brain. It is vital that
such plasticity be tightly regulated so that it occurs to the proper extent at the proper time …

Amyloid-β precursor protein (APP) is a membrane-spanning protein with a large
extracellular domain and a much smaller intracellular domain. It is the source of the amyloid …

Long-term potentiation (LTP) is widely regarded as a memory mechanism, but it is not
known whether it can last long enough to underlie very long-term memory. We report that …

Long-term depression (LTD) is a lasting decrease in synaptic effectiveness that follows
some types of electrical stimulation in the hippocampus. Two broad types of LTD may be …

The conditions responsible for the associative properties of long-term potentiation (LTP)
were examined in the CA1 region of the hippocampal slice preparation. Intracellularly …

Immediate early genes (IEGs) are a class of genes that show rapid and transient but protein
synthesisindependent increases in expression to extracellular signals such as growth …

The duration of long-term potentiation in the dentate gyrus of awake rats was examined
following systematic manipulation of the number of stimulus trains delivered. This was …

Memory maintenance is widely believed to involve long-term retention of the synaptic
weights that are set within relevant neural circuits during learning. However, despite recent …

The paramount feature of long-term potentiation (LTP) as a memory mechanism is its
characteristic persistence over time. Although the basic phenomenology of LTP persistence …