Onchocerciasis in a nonendemic population: clinical and immunologic assessment before treatment and at the time of presumed cure
NL Henry, M Law, TB Nutman… - The Journal of infectious …, 2001 - academic.oup.com
Although suppressive therapy for onchocerciasis with intermittent ivermectin prevents the
development of pathology in endemic populations, the clinical and immunologic effects of …
development of pathology in endemic populations, the clinical and immunologic effects of …
Assessing the Success of Mobile Banking in Saudi Arabia: Re-Specification and Validation of the DeLeone and McLean Model
This study aims at re-specifying and extending the DeLone and McLean information
systems success model and verifying the extended model in the context of mobile banking …
systems success model and verifying the extended model in the context of mobile banking …
[CITATION][C] First field examination of the near-surface rim structure on a large impact crater, Opportunity Rover, Endeavour Crater, Mars
LS Crumpler, RE Arvidson… - … Society of America …, 2018 - ui.adsabs.harvard.edu
… DOI: 10.1130/abs/2018AM-318088 …
[PDF][PDF] What is the Intercity Rail Passenger Market? Can it be Financed and Operated?
CR Englund Jr - 1970 - ageconsearch.umn.edu
Mr. Livingston's discussion of capital requirements 1970-1980 certainly has made abundantly
clear the railroads' growing lack of capability to raise adequate funds for necessary basic …
clear the railroads' growing lack of capability to raise adequate funds for necessary basic …
2-Alkylamino-and alkoxy-substituted 2-amino-1, 3, 4-oxadiazoles—O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against …
JS Warmus, C Flamme, LY Zhang, S Barrett… - Bioorganic & medicinal …, 2008 - Elsevier
This paper reports a second generation MEK inhibitor. The previously reported potent and
efficacious MEK inhibitor, PD-184352 (CI-1040), contains an integral hydroxamate moiety. …
efficacious MEK inhibitor, PD-184352 (CI-1040), contains an integral hydroxamate moiety. …
[PDF][PDF] Financial analysis techniques
E Henry, TR Robinson… - Financial reporting & …, 2012 - academia.edu
… The change in Acer’s revenue for FY2009 versus FY2005 is 80.4 percent calculated as (573,983
– 318,088) ÷ 318,088 or equivalently (573,983 ÷ 318,088) – 1. The compound annual …
– 318,088) ÷ 318,088 or equivalently (573,983 ÷ 318,088) – 1. The compound annual …
Screening of protein kinases by ATP-STD NMR spectroscopy
MA McCoy, MM Senior, DF Wyss - Journal of the American …, 2005 - ACS Publications
… (Figure 3a) shows the binding site of PD 318088 to be proximal to ATP. The binding of …
inhibitor (PD 318088), MgATP and MEK1 (from patent EP 1321518). PD 318088 is a non-ATP …
inhibitor (PD 318088), MgATP and MEK1 (from patent EP 1321518). PD 318088 is a non-ATP …
Structure-based design and synthesis of bicyclic fused-pyridines as MEK inhibitors
… In 2004, Pfizer scientists disclosed the X-ray co-crystal structure of MEK with PD-318088 (Fig.
2). The structure provides valuable insight into the mechanism of non-ATP competitive …
2). The structure provides valuable insight into the mechanism of non-ATP competitive …
[HTML][HTML] Integrated profiling uncovers prognostic, immunological, and pharmacogenomic features of ferroptosis in triple-negative breast cancer
K Fang, Z Xu, S Jiang, C Yan, D Tang… - Frontiers in …, 2022 - frontiersin.org
Objective Ferroptosis is an iron-dependent type of regulated cell death triggered by the toxic
buildup of lipid peroxides on cell membranes. Nonetheless, the implication of ferroptosis in …
buildup of lipid peroxides on cell membranes. Nonetheless, the implication of ferroptosis in …
MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer
T Zhan, G Ambrosi, AM Wandmacher… - Nature …, 2019 - nature.com
In colorectal cancer (CRC), aberrant Wnt signalling is essential for tumorigenesis and
maintenance of cancer stem cells. However, how other oncogenic pathways converge on Wnt …
maintenance of cancer stem cells. However, how other oncogenic pathways converge on Wnt …