The extracellular matrix: not just pretty fibrils

RO Hynes - Science, 2009 - science.org
The extracellular matrix (ECM) and ECM proteins are important in phenomena as diverse as
developmental patterning, stem cell niches, cancer, and genetic diseases. The ECM has …

Mechanics of 3D cell–hydrogel interactions: experiments, models, and mechanisms

FJ Vernerey, S Lalitha Sridhar, A Muralidharan… - Chemical …, 2021 - ACS Publications
Hydrogels are highly water-swollen molecular networks that are ideal platforms to create
tissue mimetics owing to their vast and tunable properties. As such, hydrogels are promising …

GS3, a major QTL for grain length and weight and minor QTL for grain width and thickness in rice, encodes a putative transmembrane protein

C Fan, Y Xing, H Mao, T Lu, B Han, C Xu, X Li… - Theoretical and applied …, 2006 - Springer
The GS3 locus located in the pericentromeric region of rice chromosome 3 has been
frequently identified as a major QTL for both grain weight (a yield trait) and grain length (a …

Regulation of matrix biology by matrix metalloproteinases

JD Mott, Z Werb - Current opinion in cell biology, 2004 - Elsevier
Matrix metalloproteinases (MMPs) are endopeptidases that contribute to growth,
development and wound healing as well as to pathologies such as arthritis and cancer. Until …

Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β

JG Abreu, NI Ketpura, B Reversade… - Nature cell …, 2002 - nature.com
Connective-tissue growth factor (CTGF) is a secreted protein implicated in multiple cellular
events including angiogenesis, skeletogenesis and wound healing. It is a member of the …

Extracellular matrix in uterine leiomyoma pathogenesis: a potential target for future therapeutics

MS Islam, A Ciavattini, F Petraglia… - Human reproduction …, 2018 - academic.oup.com
BACKGROUND Uterine leiomyoma (also known as fibroid or myoma) is the most common
benign tumor of the uterus found in women of reproductive age. It is not usually fatal but can …

Structural biology and evolution of the TGF-β family

AP Hinck, TD Mueller… - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
We review the evolution and structure of members of the transforming growth factor β (TGF-
β) family, antagonistic or agonistic modulators, and receptors that regulate TGF-β signaling …

DORSAL-VENTRAL PATTERNING AND NEURAL INDUCTION IN XENOPUS EMBRYOS

EM De Robertis, H Kuroda - Annu. Rev. Cell Dev. Biol., 2004 - annualreviews.org
▪ Abstract We review the current status of research in dorsal-ventral (DV) patterning in
vertebrates. Emphasis is placed on recent work on Xenopus, which provides a paradigm for …

BMP signaling pathway in dentin development and diseases

M Liu, G Goldman, M MacDougall, S Chen - Cells, 2022 - mdpi.com
BMP signaling plays an important role in dentin development. BMPs and antagonists
regulate odontoblast differentiation and downstream gene expression via canonical Smad …

Advances in early kidney specification, development and patterning

GR Dressler - Development, 2009 - journals.biologists.com
The kidney is a model developmental system for understanding mesodermal patterning and
organogenesis, a process that requires regional specification along multiple body axes, the …