Biofilms as protective cocoons against biocides: from bacterial adaptation to One Health issues

R Charron, M Boulanger, R Briandet… - Microbiology, 2023 - microbiologyresearch.org
Bacteria in the food chain mostly live in communities associated with surfaces known as
biofilms, which confer specific survival and adaptive abilities. In such communities, the …

Contribution of RND-Type Efflux Pumps in Reduced Susceptibility to Biocides in Acinetobacter baumannii

C Meyer, K Lucaβen, S Gerson, K Xanthopoulou… - Antibiotics, 2022 - mdpi.com
Bacterial efflux pumps are among the key mechanisms of resistance against antibiotics and
biocides. We investigated whether differential expression levels of the RND-type efflux …

Phylogenomic and phenotypic analyses highlight the diversity of antibiotic resistance and virulence in both human and non-human Acinetobacter baumannii

EME Sykes, V Mateo-Estrada, R Engelberg… - Msphere, 2024 - Am Soc Microbiol
Acinetobacter baumannii is a Gram-negative, opportunistic pathogen that causes infections
in the immunocompromised. With a high incidence of muti-drug resistance, carbapenem …

Resveratrol reverts tolerance and restores susceptibility to chlorhexidine and benzalkonium in gram-negative bacteria, gram-positive bacteria and yeasts

A Migliaccio, M Stabile, M Bagattini, M Triassi… - Antibiotics, 2022 - mdpi.com
The spread of microorganisms causing health-care associated infection (HAI) is contributed
to by their intrinsic tolerance to a variety of biocides, used as antiseptics or disinfectants. The …

PYED-1 Overcomes Colistin Resistance in Acinetobacter baumannii

M Stabile, A Esposito, VD Iula, A Guaragna… - Pathogens, 2023 - mdpi.com
Antibiotic resistance has become more and more widespread over the recent decades,
becoming a major global health problem and causing colistin to be increasingly used as an …

Insights into the Intersection of Biocide Resistance, Efflux Pumps, and Sequence Types in Carbapenem-Resistant Acinetobacter baumannii: A Multicenter Study

Z Taj, MH Rasool, M Khurshid, B Aslam, MU Qamar - Pathogens, 2023 - mdpi.com
Acinetobacter baumannii, a pathogenic bacterium acquired in hospitals, causes diverse
infections in humans. Previous studies have reported resistance among A. baumannii …

Biocides in the Hospital Environment: Application and Tolerance Development

C Geraldes, L Tavares, S Gil… - Microbial Drug Resistance, 2023 - liebertpub.com
Hospital-acquired infections are a rising problem with consequences for patients, hospitals,
and health care workers. Biocides can be employed to prevent these infections, contributing …

Assessing the Potential of N-Butyl-l-deoxynojirimycin (l-NBDNJ) in Models of Cystic Fibrosis as a Promising Antibacterial Agent

A Esposito, A Rossi, M Stabile, G Pinto… - ACS Pharmacology & …, 2024 - ACS Publications
Over the past few years, l-iminosugars have revealed attractive pharmacological properties
for managing rare diseases including Cystic Fibrosis (CF). The iminosugar N-butyl-l …

[HTML][HTML] Proguanil and chlorhexidine augment the antibacterial activities of clarithromycin and rifampicin against Acinetobacter baumannii

C Wang, T Zhang, Y Wang, Y Wang, H Pan… - International Journal of …, 2024 - Elsevier
The emergence of Acinetobacter baumannii infections as a significant healthcare concern in
hospital settings, coupled with their association with poorer clinical outcomes, has prompted …

Characterization of disinfectant susceptibility profiles among clinical isolates of Acinetobacter baumannii in Ardabil, Iran

M Namaki Kheljan, M Hassanzadeh… - Acta Microbiologica et …, 2023 - akjournals.com
Antimicrobial disinfectants have been extensively used to control hospital-acquired
infections worldwide. Prolonged exposure to bacteria could promote resistance to …