HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management
Abstract Human papillomavirus (HPV)-positive (HPV+) oropharyngeal squamous cell
carcinoma (OPSCC) has one of the most rapidly increasing incidences of any cancer in high …
carcinoma (OPSCC) has one of the most rapidly increasing incidences of any cancer in high …
Assessing tumor-infiltrating lymphocytes in solid tumors: a practical review for pathologists and proposal for a standardized method from the International Immuno …
S Hendry, R Salgado, T Gevaert… - Advances in anatomic …, 2017 - journals.lww.com
Assessment of the immune response to tumors is growing in importance as the prognostic
implications of this response are increasingly recognized, and as immunotherapies are …
implications of this response are increasingly recognized, and as immunotherapies are …
Head and neck squamous cell carcinoma: Genomics and emerging biomarkers for immunomodulatory cancer treatments
Head and neck squamous cell carcinoma (HNSCC) comprises a heterogeneous group of
tumors that arise from the squamous epithelium of the oral cavity, oropharynx, larynx and …
tumors that arise from the squamous epithelium of the oral cavity, oropharynx, larynx and …
HYPE or HOPE: the prognostic value of infiltrating immune cells in cancer
TA Barnes, E Amir - British journal of cancer, 2017 - nature.com
Interactions between immune and malignant cells have been known to have clinical
relevance for decades. The potential for immune control is now being therapeutically …
relevance for decades. The potential for immune control is now being therapeutically …
Assessing the interactions between radiotherapy and antitumour immunity
C Grassberger, SG Ellsworth, MQ Wilks… - Nature reviews Clinical …, 2019 - nature.com
Immunotherapy, specifically the introduction of immune checkpoint inhibitors, has
transformed the treatment of cancer, enabling long-term tumour control even in individuals …
transformed the treatment of cancer, enabling long-term tumour control even in individuals …
Resistance to radiotherapy and PD-L1 blockade is mediated by TIM-3 upregulation and regulatory T-cell infiltration
Purpose: Radiotherapy (RT) can transform the immune landscape and render poorly
immunogenic tumors sensitive to PD-L1 inhibition. Here, we established that the response to …
immunogenic tumors sensitive to PD-L1 inhibition. Here, we established that the response to …
Hypoxia compromises anti-cancer immune responses
G Multhoff, P Vaupel - Oxygen transport to tissue XLI, 2020 - Springer
Hypoxia, one of the hallmarks of cancer, is caused by an insufficient oxygen supply, mostly
due to a chaotic, deficient tumor microcirculation. Apart from a hypoxia-mediated resistance …
due to a chaotic, deficient tumor microcirculation. Apart from a hypoxia-mediated resistance …
Diagnostic tumor markers in head and neck squamous cell carcinoma (HNSCC) in the clinical setting
P Economopoulou, R De Bree, I Kotsantis… - Frontiers in …, 2019 - frontiersin.org
Head and neck squamous cell carcinoma (HNSCC) represents a group of tumors arising in
the oral cavity, oropharynx, and larynx. Although HNSCC is traditionally associated with …
the oral cavity, oropharynx, and larynx. Although HNSCC is traditionally associated with …
PD-L1 expression on immune cells, but not on tumor cells, is a favorable prognostic factor for head and neck cancer patients
To investigate the expression of programmed death-ligand 1 (PD-L1) and immune
checkpoints and their prognostic value for resected head and neck squamous cell cancer …
checkpoints and their prognostic value for resected head and neck squamous cell cancer …
Head and neck cancer: improving outcomes with a multidisciplinary approach
C Lo Nigro, N Denaro, A Merlotti… - Cancer management and …, 2017 - Taylor & Francis
For early-stage head and neck cancer (HNC), surgery (S) or radiotherapy (RT) is a standard
treatment. The multidisciplinary approach, which includes multimodality treatment with S …
treatment. The multidisciplinary approach, which includes multimodality treatment with S …