The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …

The Wnt pathway is central to a host of developmental and disease-related processes. The
remarkable conservation of this intercellular signaling cascade throughout metazoan …

The WNT signal transduction cascade is a main regulator of development throughout the
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …

Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling
embryonic and organ development, as well as cancer progression. Genome-wide …

The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication
system that is important for stem cell renewal, cell proliferation and cell differentiation both …

The blood-brain barrier (BBB) protects the central nervous system (CNS) from harmful blood-
borne factors. Although BBB dysfunction is a hallmark of several neurological disorders …

Wnt signaling has multiple functions beyond the transcriptional effects of β-catenin
stabilization. We review recent investigations that uncover new cell physiological effects …

Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …

The purine alkaloid caffeine is the most widely consumed psychostimulant drug in the world
and has multiple beneficial pharmacological activities, for example, in neurodegenerative …

The evolutionarily conserved Wnt signaling pathway plays essential roles during embryonic
development and tissue homeostasis. Notably, comprehensive genetic studies in …