The simultaneous intake of food and drugs can have a strong impact on drug release,
absorption, distribution, metabolism and/or elimination and consequently, on the efficacy …

Polyphenols are an important component of plant-derived food with a wide spectrum of
beneficial effects on human health. For many years, they have aroused great interest …

Uptake and efflux transporters determine plasma and tissue concentrations of a broad
variety of drugs. They are localized in organs such as small intestine, liver, and kidney …

Sulforaphane is an isothiocyanate occurring in stored form as glucoraphanin in cruciferous
vegetables such as cabbage, cauliflower, and kale, and at high levels in broccoli especially …

Drug interactions occur when the efficacy or toxicity of a medication is changed by
administration of another substance. Pharmacokinetic interactions often occur as a result of …

This chapter is an update of the data on substrates, reactions, inducers, and inhibitors of
human CYP enzymes published previously by Rendic and DiCarlo Citation 1a, Citation 1b …

The novel finding that grapefruit juice can markedly augment oral drug bioavailability was
based on an unexpected observation from an interaction study between the dihydropyridine …

Cytochrome P450 (CYP) enzymes in extrahepatic tissues often play a dominant role in
target tissue metabolic activation of xenobiotic compounds. They may also determine drug …

▪ Abstract Cytochrome P4503A (CYP3A) is importantly involved in the metabolism of many
chemically diverse drugs administered to humans. Moreover, its localization in high amounts …

This article provides an overview of the patient‐specific and drug‐specific variables that can
affect drug absorption following oral product administration. The oral absorption of any …