Integrin-associated signalling renders cells more resistant to genotoxic anti-cancer agents
like ionizing radiation and chemotherapeutic substances, a phenomenon termed cell …

Natural killer (NK) cells are innate lymphoid cells that hold tremendous potential for effective
immunotherapy for a broad range of cancers. Due to the mode of NK cell killing, requiring …

ABSTRACT Each year, the American Cancer Society estimates the number of new cancer
cases and deaths expected in the United States in the current year and compiles the most …

Background Definitive chemoradiotherapy (CRT) is an alternative to surgery for the curative
treatment of oesophageal carcinoma. The SCOPE1 trial aimed to investigate the addition of …

The epidermal growth factor receptor (EGFR) is a member of the ErbB family of receptors. It
is composed of extracellular domains, including a ligand-binding domain, a hydrophobic …

ABSTRACT Immunotherapy of cancer has been explored for over a century, but it is only in
the last decade that various antibody‐based products have been introduced into the …

BACKGROUND AND PURPOSE: Inhibition of EGFR-function can induce radiosensitization
in tumor cells. Purpose of our investigation was to identify the possible molecular …

Learning Objectives After completing this course, the reader will be able to: Describe the
genetic alterations frequently observed in GBM tumors as well as the cell signal transduction …

Epidermal growth factor receptor (EGFR) is a member of the ErbB family of receptors. Its
stimulation by endogenous ligands, EGF or transforming growth factor-alpha (TGF-α) results …

Purpose: It is known that blockage of epidermal growth factor receptor (EGFR)/
phosphatidylinositol 3-kinase (PI3K) activity enhances radiation sensitivity of human tumor …