Cerebrovascular diseases are a leading cause of death and neurologic disability. Further
understanding of disease mechanisms and therapeutic strategies requires a deeper
knowledge of cerebrovascular cells in humans. We profiled transcriptomes of 181,388 cells
to define a cell atlas of the adult human cerebrovasculature, including endothelial cell
molecular signatures with arteriovenous segmentation and expanded perivascular cell
diversity. By leveraging this reference, we investigated cellular and molecular perturbations …