Abstract
Dectin-1 is known as a sole receptor for beta-glucan, a major cell wall component of fungal microorganisms. In the current study, we examined the role of this molecule in the host defense to Cryptococcus neoformans, an opportunistic fungal pathogen in AIDS patients. There was no significant difference in the clinical course and cytokine production between dectin-1 gene-deficient and control mice. These results indicate that dectin-1 is not likely essential for the development of host protective responses to C. neoformans.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cryptococcosis / immunology
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Cryptococcosis / prevention & control*
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Cryptococcus neoformans / immunology
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Cryptococcus neoformans / pathogenicity*
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Dendritic Cells / immunology
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Gene Deletion
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Interleukin-12 / biosynthesis*
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Lectins, C-Type
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Membrane Proteins / genetics
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Membrane Proteins / metabolism
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Membrane Proteins / physiology*
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / metabolism
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Nerve Tissue Proteins / physiology*
Substances
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Lectins, C-Type
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Membrane Proteins
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Nerve Tissue Proteins
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dectin 1
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Interleukin-12