Abstract
An imipenem-resistant Enterobacter cloacae isolate was recovered from the blood of a patient with a hematologic malignancy. Analytical isoelectric focusing, inhibitor studies, hydrolysis, induction assays, and molecular sequencing methods confirmed the presence of a NmcA carbapenem-hydrolyzing enzyme. This first report of NmcA detected in North America warrants further investigation into its distribution and clinical impact.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Bacterial Proteins*
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Drug Resistance, Microbial
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Enterobacter cloacae / drug effects
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Enterobacter cloacae / enzymology*
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Enterobacter cloacae / genetics
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Humans
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Imipenem / pharmacology*
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Isoelectric Focusing
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Leukemia, Myeloid / enzymology*
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Male
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Microbial Sensitivity Tests
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beta-Lactamases / genetics*
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beta-Lactamases / isolation & purification
Substances
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Bacterial Proteins
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Imipenem
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NmcA protein, Enterobacter cloacae
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beta-Lactamases