Steven Yukl, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address4150 Clement Street
San Francisco CA 94121
Phone415-221-4810 ext. 3930
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    Collapse Biography 
    Collapse Education and Training
    Stanford University, Palo Alto, CAB.S.06/1995Chemistry
    University of Michigan at Ann Arbor, Ann Arbor, MIM.D.06/2000Medicine
    Duke University Medical Center, Durham, NCN/A06/2004Residency, Internal Medicine and Pediatrics (Med/Peds)
    University of California, San Francisco (UCSF), San Francisco, CAN/A06/2008Fellowship, Infectious Diseases

    Collapse Overview 
    Collapse Overview
    I am a physician-scientist at UCSF and the San Francisco VA. Since 2005, I have been conducting laboratory-based research aimed at understanding the barriers to curing HIV. My laboratory focuses on investigating the mechanisms that allow HIV to establish a latent infection (which is widely regarded as the main barrier to curing HIV) in the blood and tissues. After the start of the COVID-19 pandemic, we also became interested in the transcriptional regulation of SARS-CoV-2, another RNA virus. We are currently investigating how SARS-CoV-2 subgenomic transcription (which is analogous to RNA splicing) allows for variation in the expression of different coronavirus genes over time, and how these SARS-CoV-2 subgenomic RNAs interact with human cells to govern the pathogenesis of COVID-19.

    Collapse Research 
    Collapse Research Activities and Funding
    Understanding and targeting the HIV-expressing reservoir to reduce immune activation
    NIH R01AI183666Mar 8, 2024 - Mar 7, 2029
    Role: Principal Investigator
    The heterogeneous HIV expressing reservoir: dynamics, persistence mechanisms, tissue distribution, and contribution to rebound
    NIH P01AI169606May 1, 2022 - Apr 30, 2027
    Role: Principal Investigator
    Novel single genome approaches to determine the mechanisms of HIV latent infection in blood, gut, and lymph nodes
    NIH R01DK120387Jun 1, 2019 - Apr 30, 2024
    Role: Principal Investigator
    Understanding HIV latency reversal and clearance of infected cells in vivo
    NIH R01AI132128Jul 21, 2017 - Jun 30, 2022
    Role: Principal Investigator
    Investigating Mechanisms of HIV Persistence in the Gut
    NIH R01DK108349Sep 21, 2015 - Aug 31, 2021
    Role: Principal Investigator
    Quantification of HIV Reservoirs in the Gut-Associated Lymphatic System
    NIH IK2CX000520Aug 1, 2011 - Jul 31, 2016
    Role: Principal Investigator
    Quantification of HIV-1 Reservoirs in the Gut
    NIH K23AI089397Sep 3, 2010 - Jul 31, 2011
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mechanisms and efficacy of small molecule "latency promoting agents" to inhibit HIV reactivation ex vivo. JCI Insight. 2024 Aug 20. Janssens J, Kim P, Kim SJ, Wedrychowski A, Kadiyala GN, Hunt PW, Deeks SG, Wong JK, Yukl SA. PMID: 39163135.
      View in: PubMed   Mentions:    Fields:    
    2. Differential susceptibility of cells infected with defective and intact HIV proviruses to killing by obatoclax and other small molecules. AIDS. 2024 07 15; 38(9):1281-1291. Kadiyala GN, Telwatte S, Wedrychowski A, Janssens J, Kim SJ, Kim P, Deeks S, Wong JK, Yukl SA. PMID: 38626436; PMCID: PMC11216394.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Adaptation of Droplet Digital PCR-Based HIV Transcription Profiling to Digital PCR and Association of HIV Transcription and Total or Intact HIV DNA. Viruses. 2023 07 22; 15(7). Tumpach C, Rhodes A, Kim Y, Ong J, Liu H, Chibo D, Druce J, Williamson D, Hoh R, Deeks SG, Yukl SA, Roche M, Lewin SR, Telwatte S. PMID: 37515292; PMCID: PMC10384802.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    4. Current HIV/SIV Reservoir Assays for Preclinical and Clinical Applications: Recommendations from the Experts 2022 NIAID Workshop Summary. AIDS Res Hum Retroviruses. 2023 Jun 19. Sanders-Beer BE, Archin NM, Brumme ZL, Busch MP, Deleage C, O'Doherty U, Hughes SH, Jerome KR, Jones RB, Karn J, Kearney MF, Keele BF, Kulpa DA, Laird GM, Li JZ, Lichterfeld MD, Nussenzweig MC, Persaud D, Yukl SA, Siliciano RF, Mellors JW. PMID: 37126090.
      View in: PubMed   Mentions:    Fields:    
    5. Transcriptomic Signatures of Human Immunodeficiency Virus Post-Treatment Control. J Virol. 2023 01 31; 97(1):e0125422. Wedrychowski A, Martin HA, Li Y, Telwatte S, Kadiyala GN, Melberg M, Etemad B, Connick E, Jacobson JM, Margolis DM, Skiest D, Volberding P, Hecht F, Deeks S, Wong JK, Li JZ, Yukl SA. PMID: 36541802; PMCID: PMC9888280.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    6. OP 1.10 – 00210 Clonal Dynamics within HIV-Infected CD4 T Cell Reservoirs after PD-1 Blockade under ART. Journal of Virus Eradication. 2022 Dec 1; 8:100105. Perez PL, Reoma RL, Patro PS, Mudvari MP, Luke LB, Smith SB, Yukl YS, Kearney KM, Nath NA, Boritz BE. .
      View in: Publisher Site   Mentions:
    7. New Assay Reveals Vast Excess of Defective over Intact HIV-1 Transcripts in Antiretroviral Therapy-Suppressed Individuals. J Virol. 2022 12 21; 96(24):e0160522. Martin HA, Kadiyala GN, Telwatte S, Wedrychowski A, Chen TH, Moron-Lopez S, Arneson D, Hoh R, Deeks S, Wong J, Yukl SA. PMID: 36448806; PMCID: PMC9769383.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    8. ABX464 Decreases the Total Human Immunodeficiency Virus (HIV) Reservoir and HIV Transcription Initiation in CD4+ T Cells From Antiretroviral Therapy-Suppressed Individuals Living With HIV. Clin Infect Dis. 2022 06 10; 74(11):2044-2049. Moron-Lopez S, Bernal S, Wong JK, Martinez-Picado J, Yukl SA. PMID: 34436569; PMCID: PMC9187309.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCellsCTClinical Trials
    9. Novel assays to investigate the mechanisms of latent infection with HIV-2. PLoS One. 2022; 17(4):e0267402. Lu MD, Telwatte S, Kumar N, Ferreira F, Martin HA, Kadiyala GN, Wedrychowski A, Moron-Lopez S, Chen TH, Goecker EA, Coombs RW, Lu CM, Wong JK, Tsibris A, Yukl SA. PMID: 35476802; PMCID: PMC9045618.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. Common and Divergent Features of T Cells from Blood, Gut, and Genital Tract of Antiretroviral Therapy-Treated HIV+ Women. J Immunol. 2022 04 01; 208(7):1790-1801. Xie G, Moron-Lopez S, Siegel DA, Yin K, Polos A, Cohen J, Greenblatt RM, Tien PC, Lee SA, Yukl SA, Roan NR. PMID: 35296537; PMCID: PMC8976750.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    11. Parallel analysis of transcription, integration, and sequence of single HIV-1 proviruses. Cell. 2022 01 20; 185(2):266-282.e15. Einkauf KB, Osborn MR, Gao C, Sun W, Sun X, Lian X, Parsons EM, Gladkov GT, Seiger KW, Blackmer JE, Jiang C, Yukl SA, Rosenberg ES, Yu XG, Lichterfeld M. PMID: 35026153; PMCID: PMC8809251.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansCells
    12. Gag p24 Is a Marker of Human Immunodeficiency Virus Expression in Tissues and Correlates With Immune Response. J Infect Dis. 2021 11 16; 224(9):1593-1598. Wu G, Zuck P, Goh SL, Milush JM, Vohra P, Wong JK, Somsouk M, Yukl SA, Shacklett BL, Chomont N, Haase AT, Hatano H, Schacker TW, Deeks SG, Hazuda DJ, Hunt PW, Howell BJ. PMID: 33693750; PMCID: PMC8599810.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    13. Tissue-specific differences in HIV DNA levels and mechanisms that govern HIV transcription in blood, gut, genital tract and liver in ART-treated women. J Int AIDS Soc. 2021 07; 24(7):e25738. Moron-Lopez S, Xie G, Kim P, Siegel DA, Lee S, Wong JK, Price JC, Elnachef N, Greenblatt RM, Tien PC, Roan NR, Yukl SA. PMID: 34235864; PMCID: PMC8264406.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    14. Novel RT-ddPCR assays for measuring the levels of subgenomic and genomic SARS-CoV-2 transcripts. Methods. 2022 05; 201:15-25. Telwatte S, Martin HA, Marczak R, Fozouni P, Vallejo-Gracia A, Kumar GR, Murray V, Lee S, Ott M, Wong JK, Yukl SA. PMID: 33882362; PMCID: PMC8105137.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    15. Novel RT-ddPCR assays for simultaneous quantification of multiple noncoding and coding regions of SARS-CoV-2 RNA. J Virol Methods. 2021 06; 292:114115. Telwatte S, Kumar N, Vallejo-Gracia A, Kumar GR, Lu CM, Ott M, Wong JK, Yukl SA. PMID: 33667568; PMCID: PMC7923865.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    16. Relationship between CD4 T cell turnover, cellular differentiation and HIV persistence during ART. PLoS Pathog. 2021 01; 17(1):e1009214. Bacchus-Souffan C, Fitch M, Symons J, Abdel-Mohsen M, Reeves DB, Hoh R, Stone M, Hiatt J, Kim P, Chopra A, Ahn H, York VA, Cameron DL, Hecht FM, Martin JN, Yukl SA, Mallal S, Cameron PU, Deeks SG, Schiffer JT, Lewin SR, Hellerstein MK, McCune JM, Hunt PW. PMID: 33465157; PMCID: PMC7846027.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    17. Novel RT-ddPCR Assays for determining the transcriptional profile of SARS-CoV-2. bioRxiv. 2021 Jan 12. Telwatte S, Kumar N, Vallejo-Gracia A, Kumar GR, Lu CM, Ott M, Wong JK, Yukl SA. PMID: 33469579; PMCID: PMC7814816.
      View in: PubMed   Mentions:
    18. Shared Mechanisms Govern HIV Transcriptional Suppression in Circulating CD103+ and Gut CD4+ T Cells. J Virol. 2020 12 22; 95(2). Yukl SA, Khan S, Chen TH, Trapecar M, Wu F, Xie G, Telwatte S, Fulop D, Pico AR, Laird GM, Ritter KD, Jones NG, Lu CM, Siliciano RF, Roan NR, Milush JM, Somsouk M, Deeks SG, Hunt PW, Sanjabi S. PMID: 33115867; PMCID: PMC7944458.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    19. Human splice factors contribute to latent HIV infection in primary cell models and blood CD4+ T cells from ART-treated individuals. PLoS Pathog. 2020 11; 16(11):e1009060. Moron-Lopez S, Telwatte S, Sarabia I, Battivelli E, Montano M, Macedo AB, Aran D, Butte AJ, Jones RB, Bosque A, Verdin E, Greene WC, Wong JK, Yukl SA. PMID: 33253324; PMCID: PMC7728277.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    20. Mechanistic differences underlying HIV latency in the gut and blood contribute to differential responses to latency-reversing agents. AIDS. 2020 11 15; 34(14):2013-2024. Telwatte S, Kim P, Chen TH, Milush JM, Somsouk M, Deeks SG, Hunt PW, Wong JK, Yukl SA. PMID: 32910065; PMCID: PMC7990078.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    21. Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir. Elife. 2020 09 29; 9. Neidleman J, Luo X, Frouard J, Xie G, Hsiao F, Ma T, Morcilla V, Lee A, Telwatte S, Thomas R, Tamaki W, Wheeler B, Hoh R, Somsouk M, Vohra P, Milush J, James KS, Archin NM, Hunt PW, Deeks SG, Yukl SA, Palmer S, Greene WC, Roan NR. PMID: 32990219; PMCID: PMC7524554.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    22. HSF1 inhibition attenuates HIV-1 latency reversal mediated by several candidate LRAs In Vitro and Ex Vivo. Proc Natl Acad Sci U S A. 2020 07 07; 117(27):15763-15771. Timmons A, Fray E, Kumar M, Wu F, Dai W, Bullen CK, Kim P, Hetzel C, Yang C, Beg S, Lai J, Pomerantz JL, Yukl SA, Siliciano JD, Siliciano RF. PMID: 32571938; PMCID: PMC7959657.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    23. Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection. PLoS Pathog. 2020 04; 16(4):e1008450. Hsiao F, Frouard J, Gramatica A, Xie G, Telwatte S, Lee GQ, Roychoudhury P, Schwarzer R, Luo X, Yukl SA, Lee S, Hoh R, Deeks SG, Jones RB, Cavrois M, Greene WC, Roan NR. PMID: 32353080; PMCID: PMC7192375.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    24. Antiretroviral Therapy Concentrations Differ in Gut vs. Lymph Node Tissues and Are Associated With HIV Viral Transcription by a Novel RT-ddPCR Assay. J Acquir Immune Defic Syndr. 2020 04 15; 83(5):530-537. Lee SA, Telwatte S, Hatano H, Kashuba ADM, Cottrell ML, Hoh R, Liegler TJ, Stephenson S, Somsouk M, Hunt PW, Deeks SG, Yukl S, Savic RM. PMID: 32168200; PMCID: PMC7286563.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    25. OP 7.6 Tissue-specific differences in the mechanisms that govern HIV latency in blood, liver, gut and genital tract in ART-suppressed women. Journal of virus eradication. 2019 Dec 1; 5:40. Moron-Lopez MS, Xie XG, Kim KP, Wong WJ, Price PJ, Elnachef EN, Greenblatt GR, Tien TP, Roan RN, Yukl YS. .
      View in: Publisher Site   Mentions:
    26. OP 8.3 Intensification of ART with ABX464 decreases the total HIV reservoir and HIV transcription initiation in CD4 T cells from HIV-infected ART-suppressed individuals. Journal of virus eradication. 2019 Dec 1; 5:49. Moron-Lopez MS, Bernal BS, Steens SJ, Wong WJ, Martinez-Picado MJ, Yukl YS. .
      View in: Publisher Site   Mentions:
    27. PP 1.3 Single cell analysis reveals molecular signatures of HIV latency in primary cell models. Journal of virus eradication. 2019 Dec 1; 5:4. Telwatte TS, Montano MM, Resop RR, Battivelli BE, Morón-López MS, Verdin VE, Greene GW, Bosque BA, Wong WJ, Yukl YS. .
      View in: Publisher Site   Mentions:
    28. Heterogeneity in HIV and cellular transcription profiles in cell line models of latent and productive infection: implications for HIV latency. Retrovirology. 2019 11 11; 16(1):32. Telwatte S, Morón-López S, Aran D, Kim P, Hsieh C, Joshi S, Montano M, Greene WC, Butte AJ, Wong JK, Yukl SA. PMID: 31711503; PMCID: PMC6849327.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    29. 10 Tissue-specific effects of latency-reversing agents on HIV transcriptional blocks in gut and blood. Journal of virus eradication. 2019 Jul 1; 5:8. Telwatte TS, Kim KP, Chen CT, Milush MJ, Somsouk SM, Hunt HP, Deeks DS, Wong WJ, Yukl YS. .
      View in: Publisher Site   Mentions:
    30. 12 In-depth transcription profile comparison of multiple primary cell HIV latency models. Journal of virus eradication. 2019 Jul 1; 5:9. Moron-Lopez MS, Sarabia SI, Battivelli BE, Montano MM, Telwatte TS, Bosque BA, Verdin VE, Greene GW, Wong WJ, Yukl YS. .
      View in: Publisher Site   Mentions:
    31. Disruption of latent HIV in vivo during the clearance of actinic keratosis by ingenol mebutate. JCI Insight. 2019 04 04; 4(7). Jiang G, Maverakis E, Cheng MY, Elsheikh MM, Deleage C, Méndez-Lagares G, Shimoda M, Yukl SA, Hartigan-O'Connor DJ, Thompson GR, Estes JD, Wong JK, Dandekar S. PMID: 30944245; PMCID: PMC6483647.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCellsCTClinical Trials
    32. Characterization of the HIV-1 transcription profile after romidepsin administration in ART-suppressed individuals. AIDS. 2019 03 01; 33(3):425-431. Moron-Lopez S, Kim P, Søgaard OS, Tolstrup M, Wong JK, Yukl SA. PMID: 30531314; PMCID: PMC6374101.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCellsCTClinical Trials
    33. Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency. PLoS Pathog. 2018 11; 14(11):e1007357. Telwatte S, Lee S, Somsouk M, Hatano H, Baker C, Kaiser P, Kim P, Chen TH, Milush J, Hunt PW, Deeks SG, Wong JK, Yukl SA. PMID: 30440043; PMCID: PMC6237391.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    34. HIV latency in isolated patient CD4+ T cells may be due to blocks in HIV transcriptional elongation, completion, and splicing. Sci Transl Med. 2018 02 28; 10(430). Yukl SA, Kaiser P, Kim P, Telwatte S, Joshi SK, Vu M, Lampiris H, Wong JK. PMID: 29491188; PMCID: PMC5959841.
      View in: PubMed   Mentions: 170     Fields:    Translation:HumansCells
    35. HIV latency is reversed by ACSS2-driven histone crotonylation. J Clin Invest. 2018 03 01; 128(3):1190-1198. Jiang G, Nguyen D, Archin NM, Yukl SA, Méndez-Lagares G, Tang Y, Elsheikh MM, Thompson GR, Hartigan-O'Connor DJ, Margolis DM, Wong JK, Dandekar S. PMID: 29457784; PMCID: PMC5824862.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    36. Anatomic Compartments as a Barrier to HIV Cure. Encyclopedia of AIDS. 2018 Jan 1; 32-55. Yukl YS, Wong WJ. .
      View in: Publisher Site   Mentions:
    37. Acetylation. . 2018 Jan 1; 1-6. Cereseto CA, Wu WY, Davidson-Moncada DJ, Uldrick UT, Palefsky PJ, Yukl YS, Wong WJ, Makvandi-Nejad MS, Fletcher FC, Podany PA, Calcagno CA, William Wester WC, Brun-Vezinet BF, Matheron MS, Descamps DD, Toussi TS, Rosenberg RM, Singh SH, Glesby GM, Muiruri MC, Omar OH, Bartlett BJ, Libre LC, Batisse BJ, Guerrero GS, Marquet MR, Paillart PJ, Spear SM, Wu WY, Karsten KC, Pöhlmann PS, Papin PL, Daussy DC, Alfaisal AJ, Espert EL, Blanchet BF, Blanco BJ, Biard-Piechaczyk BM. .
      View in: Publisher Site   Mentions:
    38. OP4.6 Gut and blood differ in mechanisms governing HIV transcription/latency. Journal of virus eradication. 2017 Dec 1; 3:22. Telwatte TS, Lee LS, Somsouk SM, Hatano HH, Baker BC, Kim KP, Chen CT, Milush MJ, Hunt HP, Deeks DS, Wong WJ, Yukl YS. .
      View in: Publisher Site   Mentions:
    39. HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study. PLoS Med. 2017 Nov; 14(11):e1002417. Henrich TJ, Hatano H, Bacon O, Hogan LE, Rutishauser R, Hill A, Kearney MF, Anderson EM, Buchbinder SP, Cohen SE, Abdel-Mohsen M, Pohlmeyer CW, Fromentin R, Hoh R, Liu AY, McCune JM, Spindler J, Metcalf-Pate K, Hobbs KS, Thanh C, Gibson EA, Kuritzkes DR, Siliciano RF, Price RW, Richman DD, Chomont N, Siliciano JD, Mellors JW, Yukl SA, Blankson JN, Liegler T, Deeks SG. PMID: 29112956; PMCID: PMC5675377.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansCellsPHPublic Health
    40. Differentiating Immune Cell Targets in Gut-Associated Lymphoid Tissue for HIV Cure. AIDS Res Hum Retroviruses. 2017 Nov; 33(S1):S40-S58. Khan S, Telwatte S, Trapecar M, Yukl S, Sanjabi S. PMID: 28882067; PMCID: PMC5685216.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    41. An Optimized and Validated Method for Isolation and Characterization of Lymphocytes from HIV+ Human Gut Biopsies. AIDS Res Hum Retroviruses. 2017 Nov; 33(S1):S31-S39. Trapecar M, Khan S, Roan NR, Chen TH, Telwatte S, Deswal M, Pao M, Somsouk M, Deeks SG, Hunt PW, Yukl S, Sanjabi S. PMID: 28882052; PMCID: PMC5684666.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    42. A Randomized Controlled Trial of Lisinopril to Decrease Lymphoid Fibrosis in Antiretroviral-Treated, HIV-infected Individuals. Pathog Immun. 2017; 2(3):310-334. Cockerham LR, Yukl SA, Harvill K, Somsouk M, Joshi SK, Sinclair E, Liegler T, Hoh R, Lyons S, Hunt PW, Rupert A, Sereti I, Morcock DR, Rhodes A, Emson C, Hellerstein MK, Estes JD, Lewin S, Deeks SG, Hatano H. PMID: 28936485; PMCID: PMC5604865.
      View in: PubMed   Mentions: 4  
    43. Impact of Allogeneic Hematopoietic Stem Cell Transplantation on the HIV Reservoir and Immune Response in 3 HIV-Infected Individuals. J Acquir Immune Defic Syndr. 2017 07 01; 75(3):328-337. Koelsch KK, Rasmussen TA, Hey-Nguyen WJ, Pearson C, Xu Y, Bailey M, Marks KH, Sasson SC, Taylor MS, Tantau R, Obeid S, Milner B, Morrissey O, Pinto AN, Suzuki K, Busch MP, Keating SM, Kaiser P, Yukl S, Wong JK, Hiener BM, Palmer S, Zaunders J, Post JJ, Chan DJ, Avery S, Milliken ST, Kelleher AD, Lewin SR, Cooper DA. PMID: 28350553; PMCID: PMC6097982.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    44. Exploring HIV latency using transcription profiling. Microbiology Australia. 2017 Jan 1. Telwatte TS, Yukl YS. .
      View in: Publisher Site   Mentions:
    45. Assays for precise quantification of total (including short) and elongated HIV-1 transcripts. J Virol Methods. 2017 04; 242:1-8. Kaiser P, Joshi SK, Kim P, Li P, Liu H, Rice AP, Wong JK, Yukl SA. PMID: 28034670; PMCID: PMC5560404.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    46. Anti-HIV Antibody Responses and the HIV Reservoir Size during Antiretroviral Therapy. PLoS One. 2016; 11(8):e0160192. Lee SA, Bacchetti P, Chomont N, Fromentin R, Lewin SR, O'Doherty U, Palmer S, Richman DD, Siliciano JD, Yukl SA, Deeks SG, Burbelo PD. PMID: 27483366; PMCID: PMC4970722.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    47. Tissue reservoirs of HIV. Curr Opin HIV AIDS. 2016 07; 11(4):362-70. Wong JK, Yukl SA. PMID: 27259045; PMCID: PMC4928570.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansCells
    48. Stimulating the RIG-I pathway to kill cells in the latent HIV reservoir following viral reactivation. Nat Med. 2016 07; 22(7):807-11. Li P, Kaiser P, Lampiris HW, Kim P, Yukl SA, Havlir DV, Greene WC, Wong JK. PMID: 27294875; PMCID: PMC5004598.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    49. Site-specific differences in T cell frequencies and phenotypes in the blood and gut of HIV-uninfected and ART-treated HIV+ adults. PLoS One. 2015; 10(3):e0121290. Yukl SA, Shergill AK, Girling V, Li Q, Killian M, Epling L, Li P, Kaiser P, Haase A, Havlir DV, McQuaid K, Sinclair E, Wong JK. PMID: 25811360; PMCID: PMC4374729.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    50. Anatomic Compartments as a Barrier to HIV Cure. Encyclopedia of AIDS. 2015 Jan 1; 1-29. Yukl YS, Wong WJ. .
      View in: Publisher Site   Mentions:
    51. CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells. PLoS One. 2014; 9(10):e110731. Cockerham LR, Siliciano JD, Sinclair E, O'Doherty U, Palmer S, Yukl SA, Strain MC, Chomont N, Hecht FM, Siliciano RF, Richman DD, Deeks SG. PMID: 25340755; PMCID: PMC4207702.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    52. Exogenous and endogenous hyaluronic acid reduces HIV infection of CD4(+) T cells. Immunol Cell Biol. 2014 Oct; 92(9):770-80. Li P, Fujimoto K, Bourguingnon L, Yukl S, Deeks S, Wong JK. PMID: 24957217; PMCID: PMC4205896.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    53. Decreased HIV type 1 transcription in CCR5-Δ32 heterozygotes during suppressive antiretroviral therapy. J Infect Dis. 2014 Dec 01; 210(11):1838-43. Wang C, Abdel-Mohsen M, Strain MC, Lada SM, Yukl S, Cockerham LR, Pilcher CD, Hecht FM, Sinclair E, Liegler T, Richman DD, Deeks SG, Pillai SK. PMID: 24935955; PMCID: PMC4271057.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    54. Advantages of using the QIAshredder instead of restriction digestion to prepare DNA for droplet digital PCR. Biotechniques. 2014; 56(4):194-6. Yukl SA, Kaiser P, Kim P, Li P, Wong JK. PMID: 24724845; PMCID: PMC4948299.
      View in: PubMed   Mentions: 13     Fields:    
    55. Discordance between peripheral and colonic markers of inflammation during suppressive ART. J Acquir Immune Defic Syndr. 2014 Feb 01; 65(2):133-41. Dunham RM, Vujkovic-Cvijin I, Yukl SA, Broadhurst MJ, Loke P, Albright RG, Wong JK, Lederman MM, Somsouk M, Hunt PW, Martin JN, Deeks SG, McCune JM. PMID: 24121758; PMCID: PMC3997573.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    56. A comparison of methods for measuring rectal HIV levels suggests that HIV DNA resides in cells other than CD4+ T cells, including myeloid cells. AIDS. 2014 Jan 28; 28(3):439-42. Yukl SA, Sinclair E, Somsouk M, Hunt PW, Epling L, Killian M, Girling V, Li P, Havlir DV, Deeks SG, Wong JK, Hatano H. PMID: 24322272; PMCID: PMC4130176.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    57. Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers. PLoS Pathog. 2013; 9(10):e1003691. Hatano H, Yukl SA, Ferre AL, Graf EH, Somsouk M, Sinclair E, Abdel-Mohsen M, Liegler T, Harvill K, Hoh R, Palmer S, Bacchetti P, Hunt PW, Martin JN, McCune JM, Tracy RP, Busch MP, O'Doherty U, Shacklett BL, Wong JK, Deeks SG. PMID: 24130489; PMCID: PMC3795031.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCellsCTClinical Trials
    58. Comparison of HIV DNA and RNA in gut-associated lymphoid tissue of HIV-infected controllers and noncontrollers. AIDS. 2013 Sep 10; 27(14):2255-60. Hatano H, Somsouk M, Sinclair E, Harvill K, Gilman L, Cohen M, Hoh R, Hunt PW, Martin JN, Wong JK, Deeks SG, Yukl SA. PMID: 24157906; PMCID: PMC4143147.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    59. The distribution of HIV DNA and RNA in cell subsets differs in gut and blood of HIV-positive patients on ART: implications for viral persistence. J Infect Dis. 2013 Oct 15; 208(8):1212-20. Yukl SA, Shergill AK, Ho T, Killian M, Girling V, Epling L, Li P, Wong LK, Crouch P, Deeks SG, Havlir DV, McQuaid K, Sinclair E, Wong JK. PMID: 23852128; PMCID: PMC3778964.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansCells
    60. Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient. PLoS Pathog. 2013; 9(5):e1003347. Yukl SA, Boritz E, Busch M, Bentsen C, Chun TW, Douek D, Eisele E, Haase A, Ho YC, Hütter G, Justement JS, Keating S, Lee TH, Li P, Murray D, Palmer S, Pilcher C, Pillai S, Price RW, Rothenberger M, Schacker T, Siliciano J, Siliciano R, Sinclair E, Strain M, Wong J, Richman D, Deeks SG. PMID: 23671416; PMCID: PMC3649997.
      View in: PubMed   Mentions: 151     Fields:    Translation:HumansCellsCTClinical Trials
    61. Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies. PLoS Pathog. 2013 Feb; 9(2):e1003174. Eriksson S, Graf EH, Dahl V, Strain MC, Yukl SA, Lysenko ES, Bosch RJ, Lai J, Chioma S, Emad F, Abdel-Mohsen M, Hoh R, Hecht F, Hunt P, Somsouk M, Wong J, Johnston R, Siliciano RF, Richman DD, O'Doherty U, Palmer S, Deeks SG, Siliciano JD. PMID: 23459007; PMCID: PMC3573107.
      View in: PubMed   Mentions: 365     Fields:    Translation:HumansCells
    62. Role of retroviral restriction factors in the interferon-α-mediated suppression of HIV-1 in vivo. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3035-40. Pillai SK, Abdel-Mohsen M, Guatelli J, Skasko M, Monto A, Fujimoto K, Yukl S, Greene WC, Kovari H, Rauch A, Fellay J, Battegay M, Hirschel B, Witteck A, Bernasconi E, Ledergerber B, Günthard HF, Wong JK, Swiss HIV Cohort Study. PMID: 22315404; PMCID: PMC3286922.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    63. Modification of the Abbott RealTime assay for detection of HIV-1 plasma RNA viral loads less than one copy per milliliter. J Virol Methods. 2011 Aug; 175(2):261-5. Yukl SA, Li P, Fujimoto K, Lampiris H, Lu CM, Hare CB, Deeks SG, Liegler T, Pandori M, Havlir DV, Wong JK. PMID: 21536073; PMCID: PMC3827908.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    64. CD4+ T cell reconstitution, T cell activation, and memory T cell subset composition in blood and gut of HIV-negative and ART-suppressed HIV-positive patients: implications for HIV persistence in the gut. Journal of the International AIDS Society. 2010 Dec 1; 13(Suppl 3):o1. Yukl YS, Sinclair SE, Epling EL, Li LQ, Shergill SA, McQuaid MK, Duan DL, Hare HB, Lampiris LH, Haase HA, Havlir HD, Wong WJ. .
      View in: Publisher Site   Mentions:
    65. Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy. AIDS. 2010 Oct 23; 24(16):2451-60. Yukl SA, Shergill AK, McQuaid K, Gianella S, Lampiris H, Hare CB, Pandori M, Sinclair E, Günthard HF, Fischer M, Wong JK, Havlir DV. PMID: 20827162; PMCID: PMC2997807.
      View in: PubMed   Mentions: 142     Fields:    Translation:HumansCells
    66. Differences in HIV burden and immune activation within the gut of HIV-positive patients receiving suppressive antiretroviral therapy. J Infect Dis. 2010 Nov 15; 202(10):1553-61. Yukl SA, Gianella S, Sinclair E, Epling L, Li Q, Duan L, Choi AL, Girling V, Ho T, Li P, Fujimoto K, Lampiris H, Hare CB, Pandori M, Haase AT, Günthard HF, Fischer M, Shergill AK, McQuaid K, Havlir DV, Wong JK. PMID: 20939732; PMCID: PMC2997806.
      View in: PubMed   Mentions: 176     Fields:    Translation:HumansCellsCTClinical Trials
    67. Novel application of Locked Nucleic Acid chemistry for a Taqman assay for measuring diverse human immunodeficiency virus type 1 subtypes. J Virol Methods. 2010 Dec; 170(1-2):115-20. Li P, Ruel T, Fujimoto K, Hatano H, Yukl S, Eller LA, Liegler T, Kamya M, Gassasira A, Dorsey G, Rosenthal PJ, Havlir DV, Wong JK. PMID: 20863855; PMCID: PMC3280821.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    68. Latently-infected CD4+ T cells are enriched for HIV-1 Tat variants with impaired transactivation activity. Virology. 2009 Apr 25; 387(1):98-108. Yukl S, Pillai S, Li P, Chang K, Pasutti W, Ahlgren C, Havlir D, Strain M, Günthard H, Richman D, Rice AP, Daar E, Little S, Wong JK. PMID: 19268337; PMCID: PMC4474533.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    69. Blood and guts and HIV: preferential HIV persistence in GI mucosa. J Infect Dis. 2008 Mar 01; 197(5):640-2. Yukl S, Wong JK. PMID: 18260765.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    70. The W(sh), W(57), and Ph Kit expression mutations define tissue-specific control elements located between -23 and -154 kb upstream of Kit. Blood. 1999 Oct 15; 94(8):2658-66. Berrozpe G, Timokhina I, Yukl S, Tajima Y, Ono M, Zelenetz AD, Besmer P. PMID: 10515869.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
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