Rohit Bose, MD, PhD

Title(s)Assistant Professor, Anatomy
SchoolSchool of Medicine
ORCID ORCID Icon0000-0002-6785-0697 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Toronto, CanadaMD/PhD2008Medicine & Molecular Genetics
    Weill Cornell Medicine, New YorkResidency, Medical Research Track2010Internal Medicine
    Memorial Sloan Kettering Cancer Center, New YorkFellowship, Medical Research Track2014Medical Oncology
    Memorial Sloan Kettering Cancer Center, New YorkFellowship2016Advanced Oncology
    Memorial Sloan Kettering Cancer Center, New YorkInstructor2018Dept. of Medicine, Genitourinary Service
    Collapse Awards and Honors
    University of Saskatchewan1995Entrance Scholarship for Full Tuition
    University of Saskatchewan1999J.F. Morgan Memorial Award for Highest Academic Achievement in Dept of Microbiology & Immunology
    University of Saskatchewan1999Biochemistry Scholarship for Highest Academic Achievement in Dept of Biochemistry
    University of Saskatchewan1999Earl of Bessborough Prize for Most Distinguished Graduate Receiving a B.Sc.
    University of Saskatchewan1999Haslam Medal for Most Distinguished Graduate of the College of Arts and Sciences
    McGill University1999(Declined) Jean Alloul Entrance Scholarship for M.D./Ph.D. Program
    University of Toronto2007John Ruffo Graduate Fellowship for Outstanding Achievement during M.D./Ph.D.
    Memorial Sloan Kettering Cancer Center2011John Mendelsohn Housestaff Teaching Award
    Dana Foundation, Memorial Sloan Kettering Cancer Center, Dana Foundation2011  - 2013Dana Fellow in Biomedical Research, Clinical Scholars Training Program
    ASCO / Conquer Cancer Foundation2013  - 2014Young Investigator Award
    Department of Defense, Prostate Cancer Research Program2013  - 2015Postdoctoral Research Training Award
    Department of Defense, Prostate Cancer Research Program2016  - 2020Physician Research Training Award
    Prostate Cancer Foundation2016  - 2019Young Investigator Award
    NIH NCI2018  - 2023K08 Mentored Clinical Scientist Research Career Development Award
    CPRIT2018(Declined) Recruitment of First-Time Tenure-Track Faculty Members Award
    UCSF2019Research Funding Pilot Award
    UCSF2020Pilot Award for Junior Investigators in Basic and Clinical/Translational Sciences
    UCSF2021Bakar Aging Research Institute Investigator Award
    American Cancer Society2022  - 2026Research Scholar Grant
    Department of Defense, Prostate Cancer Program2023  - 2026Idea Development Award

    Collapse Overview 
    Collapse Overview
    I'm a physician-scientist who sees prostate cancer patients, and runs a prostate cancer-focused research lab. Our focus is in understanding hormone-related tumor evolution and dynamics. Understanding how tumors shift their dependencies and identity during therapy is critical to improving patients' clinical care.

    Collapse Research 
    Collapse Research Activities and Funding
    Simulating Ancestrally Unbiased Tumor Evolution to Interrogate Drug Resistance
    NIH Common Fund DP2CA290244Sep 15, 2023 - Aug 31, 2028
    Role: Principal Investigator
    Profiling and Eliminating Tumor Subclones Destined for Resistance
    DOD Prostate Cancer Program P0563731Jun 20, 2023 - Jun 19, 2026
    Interrogating tumor sub-clonality and shifting dependencies to reduce castration therapy
    American Cancer Society RSG-22-021-01-CDPJul 1, 2022 - Jun 30, 2026
    Investigating How a Balance of Negative and Positive ETS Factors Controls Prostate Oncogenesis
    NIH K08CA226348Sep 15, 2018 - Aug 31, 2023
    Role: Principal Investigator

    Collapse Featured Content 
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Single-dose 177Lu-PSMA-617 followed by maintenance pembrolizumab in patients with metastatic castration-resistant prostate cancer: an open-label, dose-expansion, phase 1 trial. Lancet Oncol. 2023 11; 24(11):1266-1276. Aggarwal R, Starzinski S, de Kouchkovsky I, Koshkin V, Bose R, Chou J, Desai A, Kwon D, Kaushal S, Trihy L, Rastogi M, Ippisch R, Aslam M, Friedlander T, Feng F, Oh D, Cheung A, Small E, Evans M, Fong L, Hope TA. PMID: 37922930; PMCID: PMC10667020.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    2. Impact of Squamous Histology on Clinical Outcomes and Molecular Profiling in Metastatic Urothelial Carcinoma Patients Treated With Immune Checkpoint Inhibitors or Enfortumab Vedotin. Clin Genitourin Cancer. 2023 10; 21(5):e394-e404. Jindal T, Zhang L, Deshmukh P, Reyes K, Chan E, Kumar V, Zhu X, Maldonado E, Feng S, Johnson M, Angelidakis A, Kwon D, Desai A, Borno HT, Bose R, Wong A, Hong J, Carroll P, Meng M, Porten S, Aggarwal R, Small EJ, Fong L, Chou J, Friedlander T, de Kouchkovsky I, Koshkin VS. PMID: 37316414.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    3. Somatic alterations of TP53 and MDM2 associated with response to enfortumab vedotin in patients with advanced urothelial cancer. Front Oncol. 2023; 13:1161089. Jindal T, Zhu X, Bose R, Kumar V, Maldonado E, Deshmukh P, Shipp C, Feng S, Johnson MS, Angelidakis A, Kwon D, Borno HT, de Kouchkovsky I, Desai A, Aggarwal R, Fong L, Small EJ, Wong A, Porten S, Chou J, Friedlander T, Koshkin VS. PMID: 37091148; PMCID: PMC10113661.
      View in: PubMed   Mentions: 5  
    4. Serial stereotactic body radiation therapy for oligometastatic prostate cancer detected by novel PET-based radiotracers. Urol Oncol. 2023 03; 41(3):145.e7-145.e15. Kwon DH, Shakhnazaryan N, Shui D, Hong JC, Mohamad O, de Kouchkovsky I, Borno HT, Bose R, Chou J, Desai A, Fong L, Friedlander TW, Koshkin VS, Aggarwal RR, Feng FY, Hope TA, Small EJ. PMID: 36435709.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    5. The 5-Hydroxymethylcytosine Landscape of Prostate Cancer. Cancer Res. 2022 11 02; 82(21):3888-3902. Sjöström M, Zhao SG, Levy S, Zhang M, Ning Y, Shrestha R, Lundberg A, Herberts C, Foye A, Aggarwal R, Hua JT, Li H, Bergamaschi A, Maurice-Dror C, Maheshwari A, Chen S, Ng SWS, Ye W, Petricca J, Fraser M, Chesner L, Perry MD, Moreno-Rodriguez T, Chen WS, Alumkal JJ, Chou J, Morgans AK, Beer TM, Thomas GV, Gleave M, Lloyd P, Phillips T, McCarthy E, Haffner MC, Zoubeidi A, Annala M, Reiter RE, Rettig MB, Witte ON, Fong L, Bose R, Huang FW, Luo J, Bjartell A, Lang JM, Mahajan NP, Lara PN, Evans CP, Tran PT, Posadas EM, He C, Cui XL, Huang J, Zwart W, Gilbert LA, Maher CA, Boutros PC, Chi KN, Ashworth A, Small EJ, He HH, Wyatt AW, Quigley DA, Feng FY. PMID: 36251389; PMCID: PMC9627125.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    6. Prospective Clinical Genomic Profiling of Ewing Sarcoma: ERF and FGFR1 Mutations as Recurrent Secondary Alterations of Potential Biologic and Therapeutic Relevance. JCO Precis Oncol. 2022 08; 6:e2200048. Ogura K, Elkrief A, Bowman AS, Koche RP, de Stanchina E, Benayed R, Mauguen A, Mattar MS, Khodos I, Meyers PA, Healey JH, Tap WD, Hameed M, Zehir A, Shukla N, Sawyers C, Bose R, Slotkin E, Ladanyi M. PMID: 35952322; PMCID: PMC9384944.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. Mobile Audio Recording Technology to Promote Informed Decision Making in Advanced Prostate Cancer. JCO Oncol Pract. 2022 05; 18(5):e648-e658. Kwon DH, Karthikeyan S, Chang A, Borno HT, Koshkin VS, Desai A, Bose R, Friedlander T, Rodvelt T, Li P, Small EJ, Aggarwal RR, Belkora J. PMID: 34932386.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. The DNA methylation landscape of advanced prostate cancer. Nat Genet. 2020 08; 52(8):778-789. Zhao SG, Chen WS, Li H, Foye A, Zhang M, Sjöström M, Aggarwal R, Playdle D, Liao A, Alumkal JJ, Das R, Chou J, Hua JT, Barnard TJ, Bailey AM, Chow ED, Perry MD, Dang HX, Yang R, Moussavi-Baygi R, Zhang L, Alshalalfa M, Laura Chang S, Houlahan KE, Shiah YJ, Beer TM, Thomas G, Chi KN, Gleave M, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Yvonne Kim M, Fong L, Spratt DE, Morgan TM, Bose R, Huang FW, Li H, Chesner L, Shenoy T, Goodarzi H, Asangani IA, Sandhu S, Lang JM, Mahajan NP, Lara PN, Evans CP, Febbo P, Batzoglou S, Knudsen KE, He HH, Huang J, Zwart W, Costello JF, Luo J, Tomlins SA, Wyatt AW, Dehm SM, Ashworth A, Gilbert LA, Boutros PC, Farh K, Chinnaiyan AM, Maher CA, Small EJ, Quigley DA, Feng FY. PMID: 32661416; PMCID: PMC7454228.
      View in: PubMed   Mentions: 147     Fields:    Translation:HumansCells
    9. Genomic Alteration Burden in Advanced Prostate Cancer and Therapeutic Implications. Front Oncol. 2019; 9:1287. Ryan MJ, Bose R. PMID: 31824860; PMCID: PMC6882947.
      View in: PubMed   Mentions: 20  
    10. FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes. Nature. 2019 07; 571(7765):408-412. Adams EJ, Karthaus WR, Hoover E, Liu D, Gruet A, Zhang Z, Cho H, DiLoreto R, Chhangawala S, Liu Y, Watson PA, Davicioni E, Sboner A, Barbieri CE, Bose R, Leslie CS, Sawyers CL. PMID: 31243370; PMCID: PMC6661172.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansAnimalsCells
    11. ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis. Nature. 2017 06 29; 546(7660):671-675. Bose R, Karthaus WR, Armenia J, Abida W, Iaquinta PJ, Zhang Z, Wongvipat J, Wasmuth EV, Shah N, Sullivan PS, Doran MG, Wang P, Patruno A, Zhao Y, International SU2C/PCF Prostate Cancer Dream Team, Zheng D, Schultz N, Sawyers CL. PMID: 28614298; PMCID: PMC5576182.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    12. A role for the TGFbeta-Par6 polarity pathway in breast cancer progression. Proc Natl Acad Sci U S A. 2009 Aug 18; 106(33):14028-33. Viloria-Petit AM, David L, Jia JY, Erdemir T, Bane AL, Pinnaduwage D, Roncari L, Narimatsu M, Bose R, Moffat J, Wong JW, Kerbel RS, O'Malley FP, Andrulis IL, Wrana JL. PMID: 19667198; PMCID: PMC2729014.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    13. Regulation of planar cell polarity by Smurf ubiquitin ligases. Cell. 2009 Apr 17; 137(2):295-307. Narimatsu M, Bose R, Pye M, Zhang L, Miller B, Ching P, Sakuma R, Luga V, Roncari L, Attisano L, Wrana JL. PMID: 19379695.
      View in: PubMed   Mentions: 184     Fields:    Translation:AnimalsCells
    14. Regulation of Par6 by extracellular signals. Curr Opin Cell Biol. 2006 Apr; 18(2):206-12. Bose R, Wrana JL. PMID: 16490351.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    15. Degradation of RhoA by Smurf1 ubiquitin ligase. Methods Enzymol. 2006; 406:437-47. Wang HR, Ogunjimi AA, Zhang Y, Ozdamar B, Bose R, Wrana JL. PMID: 16472676.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    16. Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science. 2005 Mar 11; 307(5715):1603-9. Ozdamar B, Bose R, Barrios-Rodiles M, Wang HR, Zhang Y, Wrana JL. PMID: 15761148.
      View in: PubMed   Mentions: 376     Fields:    Translation:HumansAnimalsCells
    17. High-throughput mapping of a dynamic signaling network in mammalian cells. Science. 2005 Mar 11; 307(5715):1621-5. Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL. PMID: 15761153.
      View in: PubMed   Mentions: 302     Fields:    Translation:HumansAnimalsCells
    18. Income and spending patterns among panhandlers. CMAJ. 2002 Sep 03; 167(5):477-9. Bose R, Hwang SW. PMID: 12240813; PMCID: PMC121964.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    19. Spectroscopic characterization by laser flash photolysis of electrophilic intermediates derived from 4-aminostilbenes. Stilbene "nitrenium" ions and quinone methide imines. Journal of the Chemical Society, Perkin Transactions 2. 1999; (8):1591 - 1600. Bose R, Ahmad A, Dicks A, Novak M, Kayser K, McClelland R.
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