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Dual hyperpolarized [1-13C]pyruvate and [13C]urea magnetic resonance imaging of prostate cancer. Journal of Magnetic Resonance Open. 2024 Dec 1; 21:100165.
de Kouchkovsky dI, Nguyen NH, Chen CH, Liu LX, Qin QH, Stohr SB, Santos SR, Ohliger OM, Wang WZ, Bok BR, Gordon GJ, Larson LP, Frost FM, Okamoto OK, Gebrezgiabhier GD, Cooperberg CM, Vigneron VD, Kurhanewicz KJ, Aggarwal AR. .
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Protocol for producing hyperpolarized 13C-bicarbonate for clinical MRI of extracellular pH in aggressive tumors. STAR Protoc. 2024 Sep 20; 5(3):103091.
Mu C, Liu X, Riselli A, Slater J, Escobar E, Dang D, Drapeau S, Delos Santos R, Andosca S, Nguyen H, Larson PEZ, Bok R, Vigneron DB, Kurhanewicz J, Wilson DM, Flavell RR. PMID: 38943645; PMCID: PMC11261128.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
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Correlating survival outcomes in patients with advanced prostate cancer with novel hyperpolarized 13 C MRI metabolic imaging biomarkers. Journal of Clinical Oncology. 2024 Jun 1; 42(16_suppl):e15059-e15059.
Chen CH, de Kouchkovsky dI, Bok BR, Ohliger OM, Wang WZ, Gebrezgiabhier GD, Nickles NT, Carvajal CL, Gordon GJ, Larson LP, Kurhanewicz KJ, Aggarwal AR, Vigneron VD. .
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Current methods for hyperpolarized [1-13C]pyruvate MRI human studies. Magn Reson Med. 2024 Jun; 91(6):2204-2228.
Larson PEZ, Bernard JML, Bankson JA, Bøgh N, Bok RA, Chen AP, Cunningham CH, Gordon JW, Hövener JB, Laustsen C, Mayer D, McLean MA, Schilling F, Slater JB, Vanderheyden JL, von Morze C, Vigneron DB, Xu D, HP 13C MRI Consensus Group. PMID: 38441968; PMCID: PMC10997462.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Distinguishing metabolic signals of liver tumors from surrounding liver cells using hyperpolarized 13 C MRI and gadoxetate. Magn Reson Med. 2024 May; 91(5):2114-2125.
Agarwal S, Gordon J, Bok RA, von Morze C, Vigneron DB, Kurhanewicz J, Ohliger MA. PMID: 38270193.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Advanced Hyperpolarized 13C Metabolic Imaging Protocol for Patients with Gliomas: A Comprehensive Multimodal MRI Approach. Cancers (Basel). 2024 Jan 13; 16(2).
Autry AW, Vaziri S, Gordon JW, Chen HY, Kim Y, Dang D, LaFontaine M, Noeske R, Bok R, Villanueva-Meyer JE, Clarke JL, Oberheim Bush NA, Chang SM, Xu D, Lupo JM, Larson PEZ, Vigneron DB, Li Y. PMID: 38254844; PMCID: PMC10814348.
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PubMed Mentions:
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Hyperpolarized 13 C metabolic imaging of the human abdomen with spatiotemporal denoising. Magn Reson Med. 2024 May; 91(5):2153-2161.
Nickles TM, Kim Y, Lee PM, Chen HY, Ohliger M, Bok RA, Wang ZJ, Larson PEZ, Vigneron DB, Gordon JW. PMID: 38193310; PMCID: PMC10950515.
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PubMed Mentions: Fields:
Translation:
Humans
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Kiosk 7R-TB-07 Quantification of Abnormal Metabolism in Hypertrophic Cardiomyopathy Patients Using Hyperpolarized [1-13c]-pyruvate MRI. Journal of Cardiovascular Magnetic Resonance. 2024 Jan 1; 26:100838.
Sinha SA, Liu LX, Tang TS, Dwork DN, Sivalokanathan SS, Liu LJ, Bok BR, Ordovas OK, Slater SJ, Gordon GJ, Abraham AR, Larson LP. .
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Hyperpolarized [1-13 C] pyruvate MRSI to detect metabolic changes in liver in a methionine and choline-deficient diet rat model of fatty liver disease. Magn Reson Med. 2024 Apr; 91(4):1625-1636.
Piraquive Agudelo J, Kim Y, Agarwal S, Sriram R, Bok R, Kurhanewicz J, Mattis AN, Maher JJ, von Morze C, Ohliger MA. PMID: 38115605; PMCID: PMC11032123.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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Regional quantification of cardiac metabolism with hyperpolarized [1-13C]-pyruvate CMR evaluated in an oral glucose challenge. J Cardiovasc Magn Reson. 2023 12 14; 25(1):77.
Larson PEZ, Tang S, Liu X, Sinha A, Dwork N, Sivalokanathan S, Liu J, Bok R, Ordovas KG, Slater J, Gordon JW, Abraham MR. PMID: 38093285; PMCID: PMC10720165.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Probing human heart TCA cycle metabolism and response to glucose load using hyperpolarized [2-13 C]pyruvate MRS. NMR Biomed. 2024 Mar; 37(3):e5074.
Chen HY, Gordon JW, Dwork N, Chung BT, Riselli A, Sivalokanathan S, Bok RA, Slater JB, Vigneron DB, Abraham MR, Larson PEZ. PMID: 38054254.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Hyperpolarized 13C Metabolic MRI of Patients with Pancreatic Ductal Adenocarcinoma. J Magn Reson Imaging. 2024 Aug; 60(2):741-749.
Gordon JW, Chen HY, Nickles T, Lee PM, Bok R, Ohliger MA, Okamoto K, Ko AH, Larson PEZ, Wang ZJ. PMID: 38041836; PMCID: PMC11144260.
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PubMed Mentions:
1 Fields:
Translation:
Humans
-
View in:
PubMed Mentions:
1 Fields:
Translation:
Humans
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Current Methods for Hyperpolarized [1-13C]pyruvate MRI Human Studies. ArXiv. 2023 Nov 22.
Larson PE, Bernard JM, Bankson JA, Bøgh N, Bok RA, Chen AP, Cunningham CH, Gordon J, Hövener JB, Laustsen C, Mayer D, McLean MA, Schilling F, Slater J, Vanderheyden JL, von Morze C, Vigneron DB, Xu D, HP 13C MRI Consensus Group. PMID: 37731660; PMCID: PMC10508833.
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PubMed Mentions:
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Clinically Translatable Hyperpolarized 13C Bicarbonate pH Imaging Method for Use in Prostate Cancer. ACS Sens. 2023 11 24; 8(11):4042-4054.
Mu C, Liu X, Kim Y, Riselli A, Korenchan DE, Bok RA, Delos Santos R, Sriram R, Qin H, Nguyen H, Gordon JW, Slater J, Larson PEZ, Vigneron DB, Kurhanewicz J, Wilson DM, Flavell RR. PMID: 37878761; PMCID: PMC10683509.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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Probing Human Heart TCA Cycle Metabolism and Response to Glucose Load using Hyperpolarized [2-13C]Pyruvate MR Spectroscopy. medRxiv. 2023 Oct 19.
Chen HY, Gordon JW, Dwork N, Chung BT, Riselli A, Sivalokanathan S, Bok RA, Slater JB, Vigneron DB, Abraham MR, Larson PEZ. PMID: 37905131; PMCID: PMC10615004.
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PubMed Mentions:
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Regional quantification of cardiac metabolism with hyperpolarized [1-13C]-pyruvate MRI evaluated in an oral glucose challenge. medRxiv. 2023 Oct 19.
Larson PEZ, Tang S, Liu X, Sinha A, Dwork N, Sivalokanathan S, Liu J, Bok R, Ordovas KG, Slater J, Gordon JW, Abraham MR. PMID: 37904936; PMCID: PMC10615005.
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PubMed Mentions:
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Investigating cerebral perfusion with high resolution hyperpolarized [1-13 C]pyruvate MRI. Magn Reson Med. 2023 12; 90(6):2233-2241.
Hu JY, Vaziri S, Bøgh N, Kim Y, Autry AW, Bok RA, Li Y, Laustsen C, Xu D, Larson PEZ, Chang S, Vigneron DB, Gordon JW. PMID: 37665726; PMCID: PMC10543485.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Hyperpolarized [2-13C]pyruvate MR molecular imaging with whole brain coverage. Neuroimage. 2023 10 15; 280:120350.
Chung BT, Kim Y, Gordon JW, Chen HY, Autry AW, Lee PM, Hu JY, Tan CT, Suszczynski C, Chang SM, Villanueva-Meyer JE, Bok RA, Larson PEZ, Xu D, Li Y, Vigneron DB. PMID: 37634883; PMCID: PMC10530049.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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A metabolite specific 3D stack-of-spirals bSSFP sequence for improved bicarbonate imaging in hyperpolarized [1-13C]Pyruvate MRI. J Magn Reson. 2023 08; 353:107518.
Liu X, Tang S, Cui D, Bok RA, Chen HY, Gordon JW, Wang ZJ, Larson PEZ. PMID: 37402333; PMCID: PMC10498937.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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Multiparametric Magnetic Resonance Imaging and Metabolic Characterization of Patient-Derived Xenograft Models of Clear Cell Renal Cell Carcinoma. Metabolites. 2022 Nov 15; 12(11).
Agudelo JP, Upadhyay D, Zhang D, Zhao H, Nolley R, Sun J, Agarwal S, Bok RA, Vigneron DB, Brooks JD, Kurhanewicz J, Peehl DM, Sriram R. PMID: 36422257; PMCID: PMC9692472.
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PubMed Mentions:
3
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Improving multiparametric MR-transrectal ultrasound guided fusion prostate biopsies with hyperpolarized 13 C pyruvate metabolic imaging: A technical development study. Magn Reson Med. 2022 Dec; 88(6):2609-2620.
Chen HY, Bok RA, Cooperberg MR, Nguyen HG, Shinohara K, Westphalen AC, Wang ZJ, Ohliger MA, Gebrezgiabhier D, Carvajal L, Gordon JW, Larson PEZ, Aggarwal R, Kurhanewicz J, Vigneron DB. PMID: 35975978; PMCID: PMC9794017.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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Kinetic analysis of multi-resolution hyperpolarized 13 C human brain MRI to study cerebral metabolism. Magn Reson Med. 2022 11; 88(5):2190-2197.
Hu JY, Kim Y, Autry AW, Frost MM, Bok RA, Villanueva-Meyer JE, Xu D, Li Y, Larson PEZ, Vigneron DB, Gordon JW. PMID: 35754148; PMCID: PMC9420752.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Development of specialized magnetic resonance acquisition techniques for human hyperpolarized [13 C,15 N2 ]urea + [1-13 C]pyruvate simultaneous perfusion and metabolic imaging. Magn Reson Med. 2022 09; 88(3):1039-1054.
Liu X, Tang S, Mu C, Qin H, Cui D, Lai YC, Riselli AM, Delos Santos R, Carvajal L, Gebrezgiabhier D, Bok RA, Chen HY, Flavell RR, Gordon JW, Vigneron DB, Kurhanewicz J, Larson PEZ. PMID: 35526263; PMCID: PMC9810116.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimals
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Whole-Abdomen Metabolic Imaging of Healthy Volunteers Using Hyperpolarized [1-13 C]pyruvate MRI. J Magn Reson Imaging. 2022 12; 56(6):1792-1806.
Lee PM, Chen HY, Gordon JW, Wang ZJ, Bok R, Hashoian R, Kim Y, Liu X, Nickles T, Cheung K, Alas FL, Daniel H, Larson PEZ, von Morze C, Vigneron DB, Ohliger MA. PMID: 35420227; PMCID: PMC9562149.
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PubMed Mentions:
10 Fields:
Translation:
Humans
-
Initial Experience on Hyperpolarized [1-13C]Pyruvate MRI Multicenter Reproducibility-Are Multicenter Trials Feasible? Tomography. 2022 03 01; 8(2):585-595.
Bøgh N, Gordon JW, Hansen ESS, Bok RA, Blicher JU, Hu JY, Larson PEZ, Vigneron DB, Laustsen C. PMID: 35314625; PMCID: PMC8938827.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Hyperpolarized 13C MRI Data Acquisition and Analysis in Prostate and Brain. . 2022 Feb 12; 1-5.
Bok BR, Vigneron VD. .
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Hyperpolarized 1-[13C]-Pyruvate Magnetic Resonance Imaging Detects an Early Metabolic Response to Immune Checkpoint Inhibitor Therapy in Prostate Cancer. Eur Urol. 2022 02; 81(2):219-221.
de Kouchkovsky I, Chen HY, Ohliger MA, Wang ZJ, Bok RA, Gordon JW, Larson PEZ, Frost M, Okamoto K, Cooperberg MR, Kurhanewicz J, Vigneron DB, Aggarwal R. PMID: 34758912; PMCID: PMC9275093.
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PubMed Mentions:
12 Fields:
Translation:
Humans
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Clinical translation of hyperpolarized 13 C pyruvate and urea MRI for simultaneous metabolic and perfusion imaging. Magn Reson Med. 2022 01; 87(1):138-149.
Qin H, Tang S, Riselli AM, Bok RA, Delos Santos R, van Criekinge M, Gordon JW, Aggarwal R, Chen R, Goddard G, Zhang CT, Chen A, Reed G, Ruscitto DM, Slater J, Sriram R, Larson PEZ, Vigneron DB, Kurhanewicz J. PMID: 34374471; PMCID: PMC8616838.
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PubMed Mentions:
20 Fields:
Translation:
Humans
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Specialized computational methods for denoising, B1 correction, and kinetic modeling in hyperpolarized 13 C MR EPSI studies of liver tumors. Magn Reson Med. 2021 11; 86(5):2402-2411.
Lee PM, Chen HY, Gordon JW, Zhu Z, Larson PEZ, Dwork N, Van Criekinge M, Carvajal L, Ohliger MA, Wang ZJ, Xu D, Kurhanewicz J, Bok RA, Aggarwal R, Munster PN, Vigneron DB. PMID: 34216051; PMCID: PMC8565779.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Metabolic MRI with hyperpolarized [1-13C]pyruvate separates benign oligemia from infarcting penumbra in porcine stroke. J Cereb Blood Flow Metab. 2021 11; 41(11):2916-2927.
Bøgh N, Olin RB, Hansen ES, Gordon JW, Bech SK, Bertelsen LB, Sánchez-Heredia JD, Blicher JU, Østergaard L, Ardenkjær-Larsen JH, Bok RA, Vigneron DB, Laustsen C. PMID: 34013807; PMCID: PMC8756460.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
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Resistance to Androgen Deprivation Leads to Altered Metabolism in Human and Murine Prostate Cancer Cell and Tumor Models. Metabolites. 2021 Feb 26; 11(3).
Sun J, Bok RA, DeLos Santos J, Upadhyay D, DeLos Santos R, Agarwal S, Van Criekinge M, Vigneron DB, Aggarwal R, Peehl DM, Kurhanewicz J, Sriram R. PMID: 33652703; PMCID: PMC7996870.
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PubMed Mentions:
11
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A variable resolution approach for improved acquisition of hyperpolarized 13 C metabolic MRI. Magn Reson Med. 2020 12; 84(6):2943-2952.
Gordon JW, Autry AW, Tang S, Graham JY, Bok RA, Zhu X, Villanueva-Meyer JE, Li Y, Ohilger MA, Abraham MR, Xu D, Vigneron DB, Larson PEZ. PMID: 32697867; PMCID: PMC7719570.
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PubMed Mentions:
22 Fields:
Translation:
Animals
-
Characterization of serial hyperpolarized 13C metabolic imaging in patients with glioma. Neuroimage Clin. 2020; 27:102323.
Autry AW, Gordon JW, Chen HY, LaFontaine M, Bok R, Van Criekinge M, Slater JB, Carvajal L, Villanueva-Meyer JE, Chang SM, Clarke JL, Lupo JM, Xu D, Larson PEZ, Vigneron DB, Li Y. PMID: 32623139; PMCID: PMC7334458.
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PubMed Mentions:
31 Fields:
Translation:
Humans
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A Metabolomics Study of Hypoxia Ischemia during Mouse Brain Development Using Hyperpolarized 13C. Dev Neurosci. 2020; 42(1):49-58.
Mikrogeorgiou A, Chen Y, Lee BS, Bok R, Sheldon RA, Barkovich AJ, Xu D, Ferriero DM. PMID: 32570236; PMCID: PMC7497410.
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PubMed Mentions:
5 Fields:
Translation:
Animals
-
Tensor image enhancement and optimal multichannel receiver combination analyses for human hyperpolarized 13 C MRSI. Magn Reson Med. 2020 12; 84(6):3351-3365.
Chen HY, Autry AW, Brender JR, Kishimoto S, Krishna MC, Vareth M, Bok RA, Reed GD, Carvajal L, Gordon JW, van Criekinge M, Korenchan DE, Chen AP, Xu D, Li Y, Chang SM, Kurhanewicz J, Larson PEZ, Vigneron DB. PMID: 32501614; PMCID: PMC7718428.
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PubMed Mentions:
18 Fields:
Translation:
Humans
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Simultaneous Metabolic and Perfusion Imaging Using Hyperpolarized 13C MRI Can Evaluate Early and Dose-Dependent Response to Radiation Therapy in a Prostate Cancer Mouse Model. Int J Radiat Oncol Biol Phys. 2020 08 01; 107(5):887-896.
Qin H, Zhang V, Bok RA, Santos RD, Cunha JA, Hsu IC, Santos Bs JD, Lee JE, Sukumar S, Larson PEZ, Vigneron DB, Wilson DM, Sriram R, Kurhanewicz J. PMID: 32339646; PMCID: PMC7381368.
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PubMed Mentions:
11 Fields:
Translation:
Animals
-
Elevated Tumor Lactate and Efflux in High-grade Prostate Cancer demonstrated by Hyperpolarized 13C Magnetic Resonance Spectroscopy of Prostate Tissue Slice Cultures. Cancers (Basel). 2020 Feb 26; 12(3).
Sriram R, Van Criekinge M, DeLos Santos J, Ahamed F, Qin H, Nolley R, Santos RD, Tabatabai ZL, Bok RA, Keshari KR, Vigneron DB, Peehl DM, Kurhanewicz J. PMID: 32110965; PMCID: PMC7139946.
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PubMed Mentions:
9
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A metabolite-specific 3D stack-of-spiral bSSFP sequence for improved lactate imaging in hyperpolarized [1-13 C]pyruvate studies on a 3T clinical scanner. Magn Reson Med. 2020 09; 84(3):1113-1125.
Tang S, Bok R, Qin H, Reed G, VanCriekinge M, Delos Santos R, Overall W, Santos J, Gordon J, Wang ZJ, Vigneron DB, Larson PEZ. PMID: 32086845; PMCID: PMC7927572.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansAnimals
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Hyperpolarized 13C-pyruvate MRI detects real-time metabolic flux in prostate cancer metastases to bone and liver: a clinical feasibility study. Prostate Cancer Prostatic Dis. 2020 06; 23(2):269-276.
Chen HY, Aggarwal R, Bok RA, Ohliger MA, Zhu Z, Lee P, Gordon JW, van Criekinge M, Carvajal L, Slater JB, Larson PEZ, Small EJ, Kurhanewicz J, Vigneron DB. PMID: 31685983; PMCID: PMC7196510.
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PubMed Mentions:
44 Fields:
Translation:
Humans
-
Hyperpolarized in vivo pH imaging reveals grade-dependent acidification in prostate cancer. Oncotarget. 2019 Oct 22; 10(58):6096-6110.
Korenchan DE, Bok R, Sriram R, Liu K, Santos RD, Qin H, Lobach I, Korn N, Wilson DM, Kurhanewicz J, Flavell RR. PMID: 31692908; PMCID: PMC6817439.
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PubMed Mentions:
8 Fields:
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First hyperpolarized [2-13C]pyruvate MR studies of human brain metabolism. J Magn Reson. 2019 12; 309:106617.
Chung BT, Chen HY, Gordon J, Mammoli D, Sriram R, Autry AW, Le Page LM, Chaumeil MM, Shin P, Slater J, Tan CT, Suszczynski C, Chang S, Li Y, Bok RA, Ronen SM, Larson PEZ, Kurhanewicz J, Vigneron DB. PMID: 31648132; PMCID: PMC6880930.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsPHPublic Health
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Amino Acid-Derived Sensors for Specific Zn2+ Detection Using Hyperpolarized 13 C Magnetic Resonance Spectroscopy. Chemistry. 2019 Sep 12; 25(51):11842-11846.
Wang S, Korenchan DE, Perez PM, Taglang C, Hayes TR, Sriram R, Bok R, Hong AS, Wu Y, Li H, Wang Z, Kurhanewicz J, Wilson DM, Flavell RR. PMID: 31338914; PMCID: PMC6742520.
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PubMed Mentions:
4 Fields:
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Kinetic Modeling of Hyperpolarized Carbon-13 Pyruvate Metabolism in the Human Brain. IEEE Trans Med Imaging. 2020 02; 39(2):320-327.
Mammoli D, Gordon J, Autry A, Larson PEZ, Li Y, Chen HY, Chung B, Shin P, Van Criekinge M, Carvajal L, Slater JB, Bok R, Crane J, Xu D, Chang S, Vigneron DB. PMID: 31283497; PMCID: PMC6939147.
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PubMed Mentions:
24 Fields:
Translation:
Humans
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Using bidirectional chemical exchange for improved hyperpolarized [13 C]bicarbonate pH imaging. Magn Reson Med. 2019 09; 82(3):959-972.
Korenchan DE, Gordon JW, Subramaniam S, Sriram R, Baligand C, VanCriekinge M, Bok R, Vigneron DB, Wilson DM, Larson PEZ, Kurhanewicz J, Flavell RR. PMID: 31050049; PMCID: PMC6559833.
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PubMed Mentions:
8 Fields:
Translation:
Animals
-
View in:
PubMed Mentions:
121 Fields:
Translation:
Humans
-
The Role of Lactate Metabolism in Prostate Cancer Progression and Metastases Revealed by Dual-Agent Hyperpolarized 13C MRSI. Cancers (Basel). 2019 Feb 22; 11(2).
Bok R, Lee J, Sriram R, Keshari K, Sukumar S, Daneshmandi S, Korenchan DE, Flavell RR, Vigneron DB, Kurhanewicz J, Seth P. PMID: 30813322; PMCID: PMC6406929.
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PubMed Mentions:
25
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Pulse sequence considerations for quantification of pyruvate-to-lactate conversion kPL in hyperpolarized 13 C imaging. NMR Biomed. 2019 03; 32(3):e4052.
Chen HY, Gordon JW, Bok RA, Cao P, von Morze C, van Criekinge M, Milshteyn E, Carvajal L, Hurd RE, Kurhanewicz J, Vigneron DB, Larson PEZ. PMID: 30664305; PMCID: PMC6380928.
View in:
PubMed Mentions:
9 Fields:
Translation:
Animals
-
Translation of Carbon-13 EPI for hyperpolarized MR molecular imaging of prostate and brain cancer patients. Magn Reson Med. 2019 04; 81(4):2702-2709.
Gordon JW, Chen HY, Autry A, Park I, Van Criekinge M, Mammoli D, Milshteyn E, Bok R, Xu D, Li Y, Aggarwal R, Chang S, Slater JB, Ferrone M, Nelson S, Kurhanewicz J, Larson PEZ, Vigneron DB. PMID: 30375043; PMCID: PMC6372313.
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PubMed Mentions:
48 Fields:
Translation:
Humans
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Dynamic diffusion-weighted hyperpolarized 13 C imaging based on a slice-selective double spin echo sequence for measurements of cellular transport. Magn Reson Med. 2019 03; 81(3):2001-2010.
Zhu X, Gordon JW, Bok RA, Kurhanewicz J, Larson PEZ. PMID: 30368893; PMCID: PMC6347546.
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PubMed Mentions:
4 Fields:
Translation:
Animals
-
Investigation of analysis methods for hyperpolarized 13C-pyruvate metabolic MRI in prostate cancer patients. NMR Biomed. 2018 11; 31(11):e3997.
Larson PEZ, Chen HY, Gordon JW, Korn N, Maidens J, Arcak M, Tang S, Criekinge M, Carvajal L, Mammoli D, Bok R, Aggarwal R, Ferrone M, Slater JB, Nelson SJ, Kurhanewicz J, Vigneron DB. PMID: 30230646; PMCID: PMC6392436.
View in:
PubMed Mentions:
52 Fields:
Translation:
Humans
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A regional bolus tracking and real-time B1 calibration method for hyperpolarized 13 C MRI. Magn Reson Med. 2019 02; 81(2):839-851.
Tang S, Milshteyn E, Reed G, Gordon J, Bok R, Zhu X, Zhu Z, Vigneron DB, Larson PEZ. PMID: 30277268; PMCID: PMC6289616.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimals
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Non-Invasive Assessment of Lactate Production and Compartmentalization in Renal Cell Carcinomas Using Hyperpolarized 13C Pyruvate MRI. Cancers (Basel). 2018 Sep 05; 10(9).
Sriram R, Gordon J, Baligand C, Ahamed F, Delos Santos J, Qin H, Bok RA, Vigneron DB, Kurhanewicz J, Larson PEZ, Wang ZJ. PMID: 30189677; PMCID: PMC6162434.
View in:
PubMed Mentions:
16
-
View in:
PubMed Mentions:
9 Fields:
Translation:
Animals
-
Spatio-Temporally Constrained Reconstruction for Hyperpolarized Carbon-13 MRI Using Kinetic Models. IEEE Trans Med Imaging. 2018 12; 37(12):2603-2612.
Maidens J, Gordon JW, Chen HY, Park I, Van Criekinge M, Milshteyn E, Bok R, Aggarwal R, Ferrone M, Slater JB, Kurhanewicz J, Vigneron DB, Arcak M, Larson PEZ. PMID: 29994332; PMCID: PMC6279499.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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Hyperpolarized C-13 pyuvate metabolic MR imaging of solid tumor liver metastases as a biomarker of PI3K/mTOR pathway activity. Journal of Clinical Oncology. 2018 May 20; 36(15_suppl):e24168-e24168.
Aggarwal AR, Zhu ZZ, Ohliger OM, Gordon GJ, Bok BR, Slater SJ, Kurhanewicz KJ, Boyd BE, Calabrese CS, Sotto SC, Vigneron VD, Munster MP. .
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Publisher Site Mentions:
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Late-stage deuteration of 13C-enriched substrates for T1 prolongation in hyperpolarized 13C MRI. Chem Commun (Camb). 2018 May 17; 54(41):5233-5236.
Taglang C, Korenchan DE, von Morze C, Yu J, Najac C, Wang S, Blecha JE, Subramaniam S, Bok R, VanBrocklin HF, Vigneron DB, Ronen SM, Sriram R, Kurhanewicz J, Wilson DM, Flavell RR. PMID: 29726563; PMCID: PMC6054790.
View in:
PubMed Mentions:
19 Fields:
-
Technique development of 3D dynamic CS-EPSI for hyperpolarized 13 C pyruvate MR molecular imaging of human prostate cancer. Magn Reson Med. 2018 11; 80(5):2062-2072.
Chen HY, Larson PEZ, Gordon JW, Bok RA, Ferrone M, van Criekinge M, Carvajal L, Cao P, Pauly JM, Kerr AB, Park I, Slater JB, Nelson SJ, Munster PN, Aggarwal R, Kurhanewicz J, Vigneron DB. PMID: 29575178; PMCID: PMC6107425.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansAnimals
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Development of methods and feasibility of using hyperpolarized carbon-13 imaging data for evaluating brain metabolism in patient studies. Magn Reson Med. 2018 09; 80(3):864-873.
Park I, Larson PEZ, Gordon JW, Carvajal L, Chen HY, Bok R, Van Criekinge M, Ferrone M, Slater JB, Xu D, Kurhanewicz J, Vigneron DB, Chang S, Nelson SJ. PMID: 29322616; PMCID: PMC5980662.
View in:
PubMed Mentions:
89 Fields:
Translation:
Humans
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Cancer recurrence monitoring using hyperpolarized [1-13C]pyruvate metabolic imaging in murine breast cancer model. Magn Reson Imaging. 2017 11; 43:105-109.
Shin PJ, Zhu Z, Camarda R, Bok RA, Zhou AY, Kurhanewicz J, Goga A, Vigneron DB. PMID: 28716678; PMCID: PMC5632580.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Assessing Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion. Cancer Res. 2017 06 15; 77(12):3207-3216.
Chen HY, Larson PEZ, Bok RA, von Morze C, Sriram R, Delos Santos R, Delos Santos J, Gordon JW, Bahrami N, Ferrone M, Kurhanewicz J, Vigneron DB. PMID: 28428273; PMCID: PMC5484421.
View in:
PubMed Mentions:
38 Fields:
Translation:
Animals
-
Hyperpolarized 13C Spectroscopic Evaluation of Oxidative Stress in a Rodent Model of Steatohepatitis. Sci Rep. 2017 04 20; 7:46014.
Wilson DM, Di Gialleonardo V, Wang ZJ, Carroll V, Von Morze C, Taylor A, Sai V, VanCriekinge M, Bok R, Ohliger MA, Keshari KR. PMID: 28425467; PMCID: PMC5397869.
View in:
PubMed Mentions:
10 Fields:
Translation:
Animals
-
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Development of high resolution 3D hyperpolarized carbon-13 MR molecular imaging techniques. Magn Reson Imaging. 2017 05; 38:152-162.
Milshteyn E, von Morze C, Reed GD, Shang H, Shin PJ, Zhu Z, Chen HY, Bok R, Goga A, Kurhanewicz J, Larson PE, Vigneron DB. PMID: 28077268; PMCID: PMC5360530.
View in:
PubMed Mentions:
13 Fields:
Translation:
Animals
-
Monitoring acute metabolic changes in the liver and kidneys induced by fructose and glucose using hyperpolarized [2-13 C]dihydroxyacetone. Magn Reson Med. 2017 01; 77(1):65-73.
Marco-Rius I, von Morze C, Sriram R, Cao P, Chang GY, Milshteyn E, Bok RA, Ohliger MA, Pearce D, Kurhanewicz J, Larson PE, Vigneron DB, Merritt M. PMID: 27859575; PMCID: PMC5191913.
View in:
PubMed Mentions:
22 Fields:
Translation:
Animals
-
Spectrally selective three-dimensional dynamic balanced steady-state free precession for hyperpolarized C-13 metabolic imaging with spectrally selective radiofrequency pulses. Magn Reson Med. 2017 09; 78(3):963-975.
Shang H, Sukumar S, von Morze C, Bok RA, Marco-Rius I, Kerr A, Reed GD, Milshteyn E, Ohliger MA, Kurhanewicz J, Larson PEZ, Pauly JM, Vigneron DB. PMID: 27770458; PMCID: PMC5400740.
View in:
PubMed Mentions:
17 Fields:
Translation:
Animals
-
Combining hyperpolarized 13 C MRI with a liver-specific gadolinium contrast agent for selective assessment of hepatocyte metabolism. Magn Reson Med. 2017 06; 77(6):2356-2363.
Ohliger MA, von Morze C, Marco-Rius I, Gordon J, Larson PEZ, Bok R, Chen HY, Kurhanewicz J, Vigneron D. PMID: 27298073; PMCID: PMC5156580.
View in:
PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry. Tomography. 2016 Jun; 2(2):125-135.
Reed GD, von Morze C, Verkman AS, Koelsch BL, Chaumeil MM, Lustig M, Ronen SM, Bok RA, Sands JM, Larson PE, Wang ZJ, Larsen JH, Kurhanewicz J, Vigneron DB. PMID: 27570835; PMCID: PMC4996281.
View in:
PubMed Mentions:
21 Fields:
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Hyperpolarized [13C]ketobutyrate, a molecular analog of pyruvate with modified specificity for LDH isoforms. Magnetic Resonance in Medicine. 2016 May 1; 75(5):spcone-spcone.
von Morze vC, Bok BR, Ohliger OM, Zhu ZZ, Vigneron VD, Kurhanewicz KJ. .
View in:
Publisher Site Mentions:
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Detection of localized changes in the metabolism of hyperpolarized gluconeogenic precursors 13 C-lactate and 13 C-pyruvate in kidney and liver. Magn Reson Med. 2017 04; 77(4):1429-1437.
von Morze C, Chang GY, Larson PE, Shang H, Allu PK, Bok RA, Crane JC, Olson MP, Tan CT, Marco-Rius I, Nelson SJ, Kurhanewicz J, Pearce D, Vigneron DB. PMID: 27098724; PMCID: PMC5074920.
View in:
PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Detecting Metabolism of Gluconeogenic Precursors Lactate and Pyruvate in Kidney & Liver with Hyperpolarized 13 C MRI. The FASEB Journal. 2016 Apr 1; 30(S1).
von Morze vC, Chang CG, Larson LP, Shang SH, Allu AP, Bok BR, Crane CJ, Olson OM, Tan TC, Marco-Rius MI, Nelson NS, Kurhanewicz KJ, Pearce PD, Vigneron VD. .
View in:
Publisher Site Mentions:
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Pyruvate to Lactate Metabolic Changes during Neurodevelopment Measured Dynamically Using Hyperpolarized 13C Imaging in Juvenile Murine Brain. Dev Neurosci. 2016; 38(1):34-40.
Chen Y, Kim H, Bok R, Sukumar S, Mu X, Sheldon RA, Barkovich AJ, Ferriero DM, Xu D. PMID: 26550989; PMCID: PMC4732911.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Application of Good's buffers to pH imaging using hyperpolarized (13)C MRI. Chem Commun (Camb). 2015 Sep 25; 51(74):14119-22.
Flavell RR, von Morze C, Blecha JE, Korenchan DE, Van Criekinge M, Sriram R, Gordon JW, Chen HY, Subramaniam S, Bok RA, Wang ZJ, Vigneron DB, Larson PE, Kurhanewicz J, Wilson DM. PMID: 26257040; PMCID: PMC4854286.
View in:
PubMed Mentions:
23 Fields:
Translation:
Cells
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Hyperpolarized [(13)C]ketobutyrate, a molecular analog of pyruvate with modified specificity for LDH isoforms. Magn Reson Med. 2016 May; 75(5):1894-900.
von Morze C, Bok RA, Ohliger MA, Zhu Z, Vigneron DB, Kurhanewicz J. PMID: 26059096; PMCID: PMC4868134.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Abstract B37: Patient-derived tissue culture model systems of renal cell carcinoma for development of clinically translatable metabolic biomarkers. Preclinical Studies. 2014 Nov 1; b37-b37.
Sriram SR, Keshari KK, Criekinge CM, Kurhanewicz KJ, Wilson WD, Peehl PD, Bok BR, Zhen ZW. .
View in:
Publisher Site Mentions:
-
View in:
PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Noninvasive in vivo imaging of diabetes-induced renal oxidative stress and response to therapy using hyperpolarized 13C dehydroascorbate magnetic resonance. Diabetes. 2015 Feb; 64(2):344-52.
Keshari KR, Wilson DM, Sai V, Bok R, Jen KY, Larson P, Van Criekinge M, Kurhanewicz J, Wang ZJ. PMID: 25187363; PMCID: PMC4303960.
View in:
PubMed Mentions:
39 Fields:
Translation:
Animals
-
A 2DRF pulse sequence for bolus tracking in hyperpolarized 13C imaging. Magn Reson Med. 2015 Aug; 74(2):506-12.
Tang S, Jiang W, Chen HY, Bok R, Vigneron DB, Larson PE. PMID: 25154961; PMCID: PMC4336852.
View in:
PubMed Mentions:
7 Fields:
Translation:
Animals
-
Simultaneous multiagent hyperpolarized (13)C perfusion imaging. Magn Reson Med. 2014 Dec; 72(6):1599-609.
von Morze C, Bok RA, Reed GD, Ardenkjaer-Larsen JH, Kurhanewicz J, Vigneron DB. PMID: 24382698; PMCID: PMC4077988.
View in:
PubMed Mentions:
28 Fields:
Translation:
Animals
-
Dynamic hyperpolarized carbon-13 MR metabolic imaging of nonhuman primate brain. Magn Reson Med. 2014 Jan; 71(1):19-25.
Park I, Larson PE, Tropp JL, Carvajal L, Reed G, Bok R, Robb F, Bringas J, Kells A, Pivirotto P, Bankiewicz K, Vigneron DB, Nelson SJ. PMID: 24346964; PMCID: PMC4041734.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansAnimals
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High resolution (13)C MRI with hyperpolarized urea: in vivo T(2) mapping and (15)N labeling effects. IEEE Trans Med Imaging. 2014 Feb; 33(2):362-71.
Reed GD, von Morze C, Bok R, Koelsch BL, Van Criekinge M, Smith KJ, Larson PE, Kurhanewicz J, Vigneron DB. PMID: 24235273; PMCID: PMC4011557.
View in:
PubMed Mentions:
50 Fields:
Translation:
Animals
-
Metabolic imaging of patients with prostate cancer using hyperpolarized [1-¹³C]pyruvate. Sci Transl Med. 2013 Aug 14; 5(198):198ra108.
Nelson SJ, Kurhanewicz J, Vigneron DB, Larson PE, Harzstark AL, Ferrone M, van Criekinge M, Chang JW, Bok R, Park I, Reed G, Carvajal L, Small EJ, Munster P, Weinberg VK, Ardenkjaer-Larsen JH, Chen AP, Hurd RE, Odegardstuen LI, Robb FJ, Tropp J, Murray JA. PMID: 23946197; PMCID: PMC4201045.
View in:
PubMed Mentions:
630 Fields:
Translation:
Humans
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WE-C-116-02: High Resolution C-13 MRI with Hyperpolarized [C-13,N-15] Urea. Medical Physics. 2013 Jun 1; 40(6Part29):484-484.
Reed RG, von Morze vC, Bok BR, Koelsch KB, Smith SK, van Criekinge vM, Larson LP, Kurhanewicz KJ, Vigneron VD. .
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Publisher Site Mentions:
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Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS. Magn Reson Med. 2014 Jan; 71(1):1-11.
Swisher CL, Larson PE, Kruttwig K, Kerr AB, Hu S, Bok RA, Goga A, Pauly JM, Nelson SJ, Kurhanewicz J, Vigneron DB. PMID: 23412881; PMCID: PMC3659200.
View in:
PubMed Mentions:
17 Fields:
Translation:
Animals
-
Combined parallel and partial fourier MR reconstruction for accelerated 8-channel hyperpolarized carbon-13 in vivo magnetic resonance Spectroscopic imaging (MRSI). J Magn Reson Imaging. 2013 Sep; 38(3):701-13.
Ohliger MA, Larson PE, Bok RA, Shin P, Hu S, Tropp J, Robb F, Carvajal L, Nelson SJ, Kurhanewicz J, Vigneron DB. PMID: 23293097; PMCID: PMC3759833.
View in:
PubMed Mentions:
19 Fields:
Translation:
HumansAnimals
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Perfusion and diffusion sensitive 13C stimulated-echo MRSI for metabolic imaging of cancer. Magn Reson Imaging. 2013 Jun; 31(5):635-42.
Larson PE, Hurd RE, Kerr AB, Pauly JM, Bok RA, Kurhanewicz J, Vigneron DB. PMID: 23260391; PMCID: PMC3626756.
View in:
PubMed Mentions:
3 Fields:
Translation:
Animals
-
Rapid sequential injections of hyperpolarized [1-¹³C]pyruvate in vivo using a sub-kelvin, multi-sample DNP polarizer. Magn Reson Imaging. 2013 May; 31(4):490-6.
Hu S, Larson PE, Vancriekinge M, Leach AM, Park I, Leon C, Zhou J, Shin PJ, Reed G, Keselman P, von Morze C, Yoshihara H, Bok RA, Nelson SJ, Kurhanewicz J, Vigneron DB. PMID: 23107275; PMCID: PMC3625683.
View in:
PubMed Mentions:
21 Fields:
Translation:
Animals
-
Frequency-specific SSFP for hyperpolarized ¹³C metabolic imaging at 14.1 T. Magn Reson Imaging. 2013 Feb; 31(2):163-70.
von Morze C, Sukumar S, Reed GD, Larson PE, Bok RA, Kurhanewicz J, Vigneron DB. PMID: 22898680; PMCID: PMC3651030.
View in:
PubMed Mentions:
22 Fields:
Translation:
HumansAnimals
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Evaluation of heterogeneous metabolic profile in an orthotopic human glioblastoma xenograft model using compressed sensing hyperpolarized 3D 13C magnetic resonance spectroscopic imaging. Magn Reson Med. 2013 Jul; 70(1):33-9.
Park I, Hu S, Bok R, Ozawa T, Ito M, Mukherjee J, Phillips JJ, James CD, Pieper RO, Ronen SM, Vigneron DB, Nelson SJ. PMID: 22851374; PMCID: PMC3630274.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Use of hyperpolarized [1-13C]pyruvate and [2-13C]pyruvate to probe the effects of the anticancer agent dichloroacetate on mitochondrial metabolism in vivo in the normal rat. Magn Reson Imaging. 2012 Dec; 30(10):1367-72.
Hu S, Yoshihara HA, Bok R, Zhou J, Zhu M, Kurhanewicz J, Vigneron DB. PMID: 22819176; PMCID: PMC3480972.
View in:
PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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A first-in-human phase I imaging study using hyperpolarized 1 c-13 pyruvate (h-Py) in patients (pts) with localized prostate cancer (l-PCa). Journal of Clinical Oncology. 2012 May 20; 30(15_suppl):4660-4660.
Harzstark HA, Weinberg WV, Grycz GK, Hurd HR, Ardenkjaer-Larsen AJ, Murray MJ, Chen CA, Ferrone FM, Park PI, Reed RG, Munster MP, Small SE, Carvajal CL, VanCriekinge VM, Larson LP, Chang CJ, Bok BR, Nelson NS, Vigneron VD, Kurhanewicz KJ. .
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Publisher Site Mentions:
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Monitoring urea transport in rat kidney in vivo using hyperpolarized ¹³C magnetic resonance imaging. Am J Physiol Renal Physiol. 2012 Jun 15; 302(12):F1658-62.
von Morze C, Bok RA, Sands JM, Kurhanewicz J, Vigneron DB. PMID: 22492940; PMCID: PMC3378100.
View in:
PubMed Mentions:
26 Fields:
Translation:
Animals
-
A method for simultaneous echo planar imaging of hyperpolarized ¹³C pyruvate and ¹³C lactate. J Magn Reson. 2012 Apr; 217:41-7.
Reed GD, Larson PE, Morze Cv, Bok R, Lustig M, Kerr AB, Pauly JM, Kurhanewicz J, Vigneron DB. PMID: 22405760; PMCID: PMC3326401.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Human prostate cancer ZIP1/zinc/citrate genetic/metabolic relationship in the TRAMP prostate cancer animal model. Cancer Biol Ther. 2011 Dec 15; 12(12):1078-84.
Costello LC, Franklin RB, Zou J, Feng P, Bok R, Swanson MG, Kurhanewicz J. PMID: 22156800; PMCID: PMC3335941.
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PubMed Mentions:
37 Fields:
Translation:
Animals
-
Investigating tumor perfusion and metabolism using multiple hyperpolarized (13)C compounds: HP001, pyruvate and urea. Magn Reson Imaging. 2012 Apr; 30(3):305-11.
von Morze C, Larson PE, Hu S, Yoshihara HA, Bok RA, Goga A, Ardenkjaer-Larsen JH, Vigneron DB. PMID: 22169407; PMCID: PMC3393100.
View in:
PubMed Mentions:
38 Fields:
Translation:
Animals
-
Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18606-11.
Keshari KR, Kurhanewicz J, Bok R, Larson PE, Vigneron DB, Wilson DM. PMID: 22042839; PMCID: PMC3219134.
View in:
PubMed Mentions:
85 Fields:
Translation:
AnimalsCells
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In vivo measurement of normal rat intracellular pyruvate and lactate levels after injection of hyperpolarized [1-(13)C]alanine. Magn Reson Imaging. 2011 Oct; 29(8):1035-40.
Hu S, Zhu M, Yoshihara HA, Wilson DM, Keshari KR, Shin P, Reed G, von Morze C, Bok R, Larson PE, Kurhanewicz J, Vigneron DB. PMID: 21855243; PMCID: PMC3172390.
View in:
PubMed Mentions:
18 Fields:
Translation:
Animals
-
13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression. Cell Metab. 2011 Jul 06; 14(1):131-42.
Hu S, Balakrishnan A, Bok RA, Anderton B, Larson PE, Nelson SJ, Kurhanewicz J, Vigneron DB, Goga A. PMID: 21723511; PMCID: PMC3858338.
View in:
PubMed Mentions:
131 Fields:
Translation:
AnimalsCells
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Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging. J Magn Reson Imaging. 2011 Jun; 33(6):1284-90.
Park I, Bok R, Ozawa T, Phillips JJ, James CD, Vigneron DB, Ronen SM, Nelson SJ. PMID: 21590996; PMCID: PMC4983457.
View in:
PubMed Mentions:
76 Fields:
Translation:
HumansAnimalsCells
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SU-E-J-130: Hyperpolarized 13C Biomarkers of Response to Prostate Cancer Radiation Therapy. Medical Physics. 2011 Jun 1; 38(6Part9):3472-3472.
Zhang ZV, Cunha CJ, Bok BR, Hsu HI, Scott SK, Sukumar SS, Kurhanewicz KJ, Pouliot PJ. .
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Publisher Site Mentions:
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Multi-band frequency encoding method for metabolic imaging with hyperpolarized [1-(13)C]pyruvate. J Magn Reson. 2011 Aug; 211(2):109-13.
von Morze C, Reed G, Shin P, Larson PE, Hu S, Bok R, Vigneron DB. PMID: 21596601; PMCID: PMC3143308.
View in:
PubMed Mentions:
17 Fields:
Translation:
Animals
-
Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models. J Magn Reson Imaging. 2011 Mar; 33(3):692-7.
von Morze C, Larson PE, Hu S, Keshari K, Wilson DM, Ardenkjaer-Larsen JH, Goga A, Bok R, Kurhanewicz J, Vigneron DB. PMID: 21563254; PMCID: PMC3566235.
View in:
PubMed Mentions:
65 Fields:
Translation:
HumansAnimalsCells
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Multi-channel metabolic imaging, with SENSE reconstruction, of hyperpolarized [1-(13)C] pyruvate in a live rat at 3.0 tesla on a clinical MR scanner. J Magn Reson. 2011 Jan; 208(1):171-7.
Tropp J, Lupo JM, Chen A, Calderon P, McCune D, Grafendorfer T, Ozturk-Isik E, Larson PE, Hu S, Yen YF, Robb F, Bok R, Schulte R, Xu D, Hurd R, Vigneron D, Nelson S. PMID: 21130012; PMCID: PMC3387549.
View in:
PubMed Mentions:
31 Fields:
Translation:
Animals
-
Metabolic imaging in the anesthetized rat brain using hyperpolarized [1-13C] pyruvate and [1-13C] ethyl pyruvate. Magn Reson Med. 2010 May; 63(5):1137-43.
Hurd RE, Yen YF, Mayer D, Chen A, Wilson D, Kohler S, Bok R, Vigneron D, Kurhanewicz J, Tropp J, Spielman D, Pfefferbaum A. PMID: 20432284; PMCID: PMC2890241.
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PubMed Mentions:
69 Fields:
Translation:
Animals
-
Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo. J Magn Reson. 2010 Jul; 205(1):141-7.
Wilson DM, Keshari KR, Larson PE, Chen AP, Hu S, Van Criekinge M, Bok R, Nelson SJ, Macdonald JM, Vigneron DB, Kurhanewicz J. PMID: 20478721; PMCID: PMC2885774.
View in:
PubMed Mentions:
95 Fields:
Translation:
Animals
-
Investigation of tumor hyperpolarized [1-13C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSI. Magn Reson Med. 2010 Mar; 63(3):582-91.
Larson PE, Bok R, Kerr AB, Lustig M, Hu S, Chen AP, Nelson SJ, Pauly JM, Kurhanewicz J, Vigneron DB. PMID: 20187172; PMCID: PMC2844437.
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PubMed Mentions:
49 Fields:
Translation:
Animals
-
3D compressed sensing for highly accelerated hyperpolarized (13)C MRSI with in vivo applications to transgenic mouse models of cancer. Magn Reson Med. 2010 Feb; 63(2):312-21.
Hu S, Lustig M, Balakrishnan A, Larson PE, Bok R, Kurhanewicz J, Nelson SJ, Goga A, Pauly JM, Vigneron DB. PMID: 20017160; PMCID: PMC2829256.
View in:
PubMed Mentions:
64 Fields:
Translation:
HumansAnimals
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Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumors. Neuro Oncol. 2010 Feb; 12(2):133-44.
Park I, Larson PE, Zierhut ML, Hu S, Bok R, Ozawa T, Kurhanewicz J, Vigneron DB, Vandenberg SR, James CD, Nelson SJ. PMID: 20150380; PMCID: PMC2940577.
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PubMed Mentions:
95 Fields:
Translation:
HumansAnimals
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Hyperpolarized [2-13C]-fructose: a hemiketal DNP substrate for in vivo metabolic imaging. J Am Chem Soc. 2009 Dec 09; 131(48):17591-6.
Keshari KR, Wilson DM, Chen AP, Bok R, Larson PE, Hu S, Van Criekinge M, Macdonald JM, Vigneron DB, Kurhanewicz J. PMID: 19860409; PMCID: PMC2796621.
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PubMed Mentions:
57 Fields:
Translation:
Animals
-
Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice. J Magn Reson. 2010 Jan; 202(1):85-92.
Zierhut ML, Yen YF, Chen AP, Bok R, Albers MJ, Zhang V, Tropp J, Park I, Vigneron DB, Kurhanewicz J, Hurd RE, Nelson SJ. PMID: 19884027; PMCID: PMC2833325.
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PubMed Mentions:
84 Fields:
Translation:
Animals
-
Analysis of hyperpolarized dynamic 13C lactate imaging in a transgenic mouse model of prostate cancer. Magn Reson Imaging. 2010 Feb; 28(2):153-62.
Lupo JM, Chen AP, Zierhut ML, Bok RA, Cunningham CH, Kurhanewicz J, Vigneron DB, Nelson SJ. PMID: 19695815; PMCID: PMC3075841.
View in:
PubMed Mentions:
25 Fields:
Translation:
HumansAnimals
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Imaging considerations for in vivo 13C metabolic mapping using hyperpolarized 13C-pyruvate. Magn Reson Med. 2009 Jul; 62(1):1-10.
Yen YF, Kohler SJ, Chen AP, Tropp J, Bok R, Wolber J, Albers MJ, Gram KA, Zierhut ML, Park I, Zhang V, Hu S, Nelson SJ, Vigneron DB, Kurhanewicz J, Dirven HA, Hurd RE. PMID: 19319902; PMCID: PMC2782538.
View in:
PubMed Mentions:
60 Fields:
Translation:
Animals
-
In vivo carbon-13 dynamic MRS and MRSI of normal and fasted rat liver with hyperpolarized 13C-pyruvate. Mol Imaging Biol. 2009 Nov-Dec; 11(6):399-407.
Hu S, Chen AP, Zierhut ML, Bok R, Yen YF, Schroeder MA, Hurd RE, Nelson SJ, Kurhanewicz J, Vigneron DB. PMID: 19424761; PMCID: PMC2763080.
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PubMed Mentions:
30 Fields:
Translation:
Animals
-
Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading. Cancer Res. 2008 Oct 15; 68(20):8607-15.
Albers MJ, Bok R, Chen AP, Cunningham CH, Zierhut ML, Zhang VY, Kohler SJ, Tropp J, Hurd RE, Yen YF, Nelson SJ, Vigneron DB, Kurhanewicz J. PMID: 18922937; PMCID: PMC2829248.
View in:
PubMed Mentions:
285 Fields:
Translation:
Animals
-
Feasibility of using hyperpolarized [1-13C]lactate as a substrate for in vivo metabolic 13C MRSI studies. Magn Reson Imaging. 2008 Jul; 26(6):721-6.
Chen AP, Kurhanewicz J, Bok R, Xu D, Joun D, Zhang V, Nelson SJ, Hurd RE, Vigneron DB. PMID: 18479878; PMCID: PMC2577896.
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PubMed Mentions:
45 Fields:
Translation:
Animals
-
Current and potential applications of clinical 13C MR spectroscopy. J Nucl Med. 2008 Mar; 49(3):341-4.
Kurhanewicz J, Bok R, Nelson SJ, Vigneron DB. PMID: 18322118; PMCID: PMC2832218.
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PubMed Mentions:
49 Fields:
Translation:
Humans
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Treatment of prostate cancer: therapeutic potential of targeted immunotherapy with APC8015. Ther Clin Risk Manag. 2008 Feb; 4(1):79-85.
Bok RA. PMID: 18728723; PMCID: PMC2503669.
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PubMed Mentions:
3
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DNP-Hyperpolarized C Magnetic Resonance Metabolic Imaging for Cancer Applications. Appl Magn Reson. 2008; 34(3-4):533-544.
Nelson SJ, Vigneron D, Kurhanewicz J, Chen A, Bok R, Hurd R. PMID: 20198109; PMCID: PMC2829774.
View in:
PubMed Mentions:
28
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Hyperpolarized C-13 spectroscopic imaging of the TRAMP mouse at 3T-initial experience. Magn Reson Med. 2007 Dec; 58(6):1099-106.
Chen AP, Albers MJ, Cunningham CH, Kohler SJ, Yen YF, Hurd RE, Tropp J, Bok R, Pauly JM, Nelson SJ, Kurhanewicz J, Vigneron DB. PMID: 17969006.
View in:
PubMed Mentions:
102 Fields:
Translation:
HumansAnimals
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Paramagnetic Silica-Coated Nanocrystals as an Advanced MRI Contrast Agent. The Journal of Physical Chemistry C. 2007 Aug 1; 111(34):12542-12551.
Gerion GD, Herberg HJ, Bok BR, Gjersing GE, Ramon RE, Maxwell MR, Kurhanewicz KJ, Budinger BT, Gray GJ, Shuman SM, Chen CF. .
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Publisher Site Mentions:
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In vivo 13 carbon metabolic imaging at 3T with hyperpolarized 13C-1-pyruvate. Magn Reson Med. 2007 Jul; 58(1):65-69.
Kohler SJ, Yen Y, Wolber J, Chen AP, Albers MJ, Bok R, Zhang V, Tropp J, Nelson S, Vigneron DB, Kurhanewicz J, Hurd RE. PMID: 17659629.
View in:
PubMed Mentions:
91 Fields:
Translation:
Animals
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Maximal COX-2 immunostaining and clinical response to celecoxib and interferon alpha therapy in metastatic renal cell carcinoma. Cancer. 2006 Feb 01; 106(3):566-75.
Rini BI, Weinberg V, Dunlap S, Elchinoff A, Yu N, Bok R, Simko J, Small EJ. PMID: 16369983.
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19 Fields:
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HumansCTClinical Trials
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Prospective, multicenter, randomized phase II trial of the herbal supplement, PC-SPES, and diethylstilbestrol in patients with androgen-independent prostate cancer. J Clin Oncol. 2004 Sep 15; 22(18):3705-12.
Oh WK, Kantoff PW, Weinberg V, Jones G, Rini BI, Derynck MK, Bok R, Smith MR, Bubley GJ, Rosen RT, DiPaola RS, Small EJ. PMID: 15289492.
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A phase II trial of interferon-alpha and celecoxib in metastatic renal carcinoma: clinical and anti-angiogenic effects. Journal of Clinical Oncology. 2004 Jul 15; 22(14_suppl):4604-4604.
Rini RB, Weinberg WV, Cadman CB, Elchinoff EA, Yu YN, Bok BR, Small SE. .
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A phase II trial of interferon-alpha and celecoxib in metastatic renal carcinoma: clinical and anti-angiogenic effects. Journal of Clinical Oncology. 2004 Jul 15; 22(14_suppl):4604-4604.
Rini RB, Weinberg WV, Cadman CB, Elchinoff EA, Yu YN, Bok BR, Small SE. .
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Time to disease progression to evaluate a novel protein kinase C inhibitor, UCN-01, in renal cell carcinoma. Cancer. 2004 Jul 01; 101(1):90-5.
Rini BI, Weinberg V, Shaw V, Scott J, Bok R, Park JW, Small EJ. PMID: 15221993.
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PubMed Mentions:
5 Fields:
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HumansCellsCTClinical Trials
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Steroid hormones, polypeptide growth factors, hormone refractory prostate cancer, and the neuroendocrine phenotype. J Cell Biochem. 2004 Mar 01; 91(4):671-83.
Evangelou AI, Winter SF, Huss WJ, Bok RA, Greenberg NM. PMID: 14991759.
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11 Fields:
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HumansAnimals
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Patterns of protease production during prostate cancer progression: proteomic evidence for cascades in a transgenic model. Prostate Cancer Prostatic Dis. 2003; 6(4):272-80.
Bok RA, Hansell EJ, Nguyen TP, Greenberg NM, McKerrow JH, Shuman MA. PMID: 14663466.
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PubMed Mentions:
10 Fields:
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AnimalsCells
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Prostate-specific antigen kinetics as a measure of the biologic effect of granulocyte-macrophage colony-stimulating factor in patients with serologic progression of prostate cancer. J Clin Oncol. 2003 Jan 01; 21(1):99-105.
Rini BI, Weinberg V, Bok R, Small EJ. PMID: 12506177.
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PubMed Mentions:
19 Fields:
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HumansCTClinical Trials
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Bloodborne biomolecular markers in prostate cancer development and progression. Nat Rev Cancer. 2002 Dec; 2(12):918-26.
Bok RA, Small EJ. PMID: 12459730.
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12 Fields:
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Humans
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Low dose ketoconazole with replacement doses of hydrocortisone in patients with progressive androgen independent prostate cancer. J Urol. 2002 Aug; 168(2):542-5.
Harris KA, Weinberg V, Bok RA, Kakefuda M, Small EJ. PMID: 12131305.
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20 Fields:
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Humans
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Low Dose Ketoconazole With Replacement Doses of Hydrocortisone in Patients With Progressive Androgen Independent Prostate Cancer. The Journal of Urology. 2002 Aug 1; 168(2):542-545.
HARRIS HK, WEINBERG WV, BOK BR, KAKEFUDA KM, SMALL SE. .
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Urokinase plasminogen activator amino-terminal peptides inhibit development of the rat ventral prostate. Differentiation. 2001 Dec; 69(2-3):108-20.
Elfman F, Bok R, Conn M, Shuman M, Cunha G. PMID: 11798065.
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HumansAnimalsCells
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The UCSF advanced prostate cancer program. Urologic Oncology Seminars and Original Investigations. 2001 Sep 1; 6(5):197-201.
Small SE, Harris HK, Frohlich FM, Bok BR. .
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Docetaxel, estramustine, plus trastuzumab in patients with metastatic androgen-independent prostate cancer. Seminars in Oncology. 2001 Aug 1; 28(4M):71-76.
Small SE, Bok BR, Reese RD, Sudilovsky SD, Frohlich FM. .
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Docetaxel, estramustine, plus trastuzumab in patients with metastatic androgen-independent prostate cancer. Semin Oncol. 2001 Aug; 28(4 Suppl 15):71-6.
Small EJ, Bok R, Reese DM, Sudilovsky D, Frohlich M. PMID: 11685733.
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PubMed Mentions:
14 Fields:
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HumansCTClinical Trials
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Vascular endothelial growth factor and basic fibroblast growth factor urine levels as predictors of outcome in hormone-refractory prostate cancer patients: a cancer and leukemia group B study. Cancer Res. 2001 Mar 15; 61(6):2533-6.
Bok RA, Halabi S, Fei DT, Rodriquez CR, Hayes DF, Vogelzang NJ, Kantoff P, Shuman MA, Small EJ. PMID: 11289126.
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PubMed Mentions:
46 Fields:
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Humans
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Prospective trial of the herbal supplement PC-SPES in patients with progressive prostate cancer. J Clin Oncol. 2000 Nov 01; 18(21):3595-603.
Small EJ, Frohlich MW, Bok R, Shinohara K, Grossfeld G, Rozenblat Z, Kelly WK, Corry M, Reese DM. PMID: 11054432.
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25 Fields:
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HumansCTClinical Trials
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The treatment of advanced prostate cancer with ketoconazole: safety issues. Drug Saf. 1999 May; 20(5):451-8.
Bok RA, Small EJ. PMID: 10348095.
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6 Fields:
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HumansAnimals
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Simultaneous antiandrogen withdrawal and treatment with ketoconazole and hydrocortisone in patients with advanced prostate carcinoma. Cancer. 1997 Nov 01; 80(9):1755-9.
Small EJ, Baron A, Bok R. PMID: 9351544.
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PubMed Mentions:
21 Fields:
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HumansCTClinical Trials
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Angiogenesis inhibition by minocycline. Cancer Res. 1991 Jan 15; 51(2):672-5.
Tamargo RJ, Bok RA, Brem H. PMID: 1702361.
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61 Fields:
Translation:
Animals