"MRE11 Homologue Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A component of the MRN complex along with Rad50 and Nibrin. Together, these perform a critical function in the repair of DOUBLE-STRANDED DNA BREAKS; RECOMBINATIONAL DNA REPAIR; maintenance of TELOMERE integrity and MEIOSIS. MRE11, which contains a poly(ADP)-ribose binding motif and associates with PARP1, possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Mutations in the MRE11 gene are associated with ATAXIA-TELANGIECTASIA-like disorder 1.
| Descriptor ID |
D000076228
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| MeSH Number(s) |
D08.811.277.352.335.350.650 D08.811.277.352.335.375.813 D08.811.277.352.355.325.600 D08.811.277.352.365.290.250 D12.776.157.687.495 D12.776.260.539 D12.776.660.720.495
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| Concept/Terms |
MRE11 Homologue Protein- MRE11 Homologue Protein
- Homologue Protein, MRE11
- MRE11A Protein
- Meiotic Recombination 11 Homolog 1 Protein
|
Below are MeSH descriptors whose meaning is more general than "MRE11 Homologue Protein".
Below are MeSH descriptors whose meaning is more specific than "MRE11 Homologue Protein".
This graph shows the total number of publications written about "MRE11 Homologue Protein" by people in this website by year, and whether "MRE11 Homologue Protein" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 4 | 4 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 3 | 3 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 3 | 3 |
| 2015 | 0 | 4 | 4 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2019 | 3 | 0 | 3 |
| 2020 | 0 | 2 | 2 |
| 2021 | 1 | 0 | 1 |
Below are the most recent publications written about "MRE11 Homologue Protein" by people in Profiles.
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Role of Ki-67, MRE11, and PD-L1 as Predictive Biomarkers for Recurrence Pattern in Muscle-invasive Bladder Cancer. Anticancer Res. 2021 Aug; 41(8):3851-3857.
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Chromatin-associated MRN complex protects highly transcribing genes from genomic instability. Sci Adv. 2021 05; 7(21).
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Modeling cancer genomic data in yeast reveals selection against ATM function during tumorigenesis. PLoS Genet. 2020 03; 16(3):e1008422.
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Rad50 zinc hook functions as a constitutive dimerization module interchangeable with SMC hinge. Nat Commun. 2020 01 17; 11(1):370.
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MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription-replication conflicts. Nat Commun. 2019 09 19; 10(1):4265.
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Nbn-Mre11 interaction is required for tumor suppression and genomic integrity. Proc Natl Acad Sci U S A. 2019 07 23; 116(30):15178-15183.
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Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq. Science. 2019 Apr 19; 364(6437):286-289.
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UFL1 promotes histone H4 ufmylation and ATM activation. Nat Commun. 2019 03 18; 10(1):1242.
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The MRE11-RAD50-NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair. Annu Rev Biochem. 2018 06 20; 87:263-294.
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Targeting Allostery with Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities. Methods Enzymol. 2018; 601:205-241.