Interferon Regulatory Factors
"Interferon Regulatory Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of transcription factors that share an N-terminal HELIX-TURN-HELIX MOTIF and bind INTERFERON-inducible promoters to control GENE expression. IRF proteins bind specific DNA sequences such as interferon-stimulated response elements, interferon regulatory elements, and the interferon consensus sequence.
| Descriptor ID |
D050835
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| MeSH Number(s) |
D12.644.360.024.302 D12.776.157.057.050 D12.776.260.504 D12.776.476.024.385 D12.776.930.332
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Interferon Regulatory Factors".
Below are MeSH descriptors whose meaning is more specific than "Interferon Regulatory Factors".
This graph shows the total number of publications written about "Interferon Regulatory Factors" by people in this website by year, and whether "Interferon Regulatory Factors" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2006 | 2 | 1 | 3 |
| 2007 | 1 | 1 | 2 |
| 2008 | 1 | 2 | 3 |
| 2009 | 4 | 1 | 5 |
| 2010 | 0 | 1 | 1 |
| 2011 | 8 | 2 | 10 |
| 2012 | 4 | 6 | 10 |
| 2013 | 7 | 3 | 10 |
| 2014 | 3 | 4 | 7 |
| 2015 | 3 | 2 | 5 |
| 2016 | 3 | 3 | 6 |
| 2017 | 7 | 6 | 13 |
| 2018 | 5 | 7 | 12 |
| 2019 | 3 | 1 | 4 |
| 2020 | 7 | 2 | 9 |
| 2021 | 5 | 8 | 13 |
| 2022 | 2 | 2 | 4 |
| 2024 | 0 | 3 | 3 |
Below are the most recent publications written about "Interferon Regulatory Factors" by people in Profiles.
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Transcription factor dependencies identify BAF-dependent cancers. Cancer Cell. 2024 Aug 12; 42(8):1326-1328.
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Peripheral T-cell lymphomas expressing CD30 and CD15 expand the spectrum of anaplastic large cell lymphoma, ALK-negative. Br J Haematol. 2024 May; 204(5):1862-1871.
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Affinity-optimizing enhancer variants disrupt development. Nature. 2024 Feb; 626(7997):151-159.
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Cis interactions in the Irf8 locus regulate stage-dependent enhancer activation. Genes Dev. 2023 04 01; 37(7-8):291-302.
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Obese Skeletal Muscle-Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome. Diabetes. 2022 11 01; 71(11):2256-2271.
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Sleep disturbance and activation of cellular and transcriptional mechanisms of inflammation in older adults. Brain Behav Immun. 2022 11; 106:67-75.
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Elevated TNF-α Leads to Neural Circuit Instability in the Absence of Interferon Regulatory Factor 8. J Neurosci. 2022 08 10; 42(32):6171-6185.
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FEZ1 phosphorylation regulates HSPA8 localization and interferon-stimulated gene expression. Cell Rep. 2022 02 15; 38(7):110396.
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CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells. Science. 2022 02 11; 375(6581):eabi5965.
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Meta-analyses identify DNA methylation associated with kidney function and damage. Nat Commun. 2021 12 09; 12(1):7174.