Don Cleveland

Title(s)Professor, Cellular and Molecular Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Overview 
    Collapse Overview
    Cleveland is interested in the genes and proteins involved in mitotic spindle assembly and faithful chromosome segregation just prior to division. This process is particularly relevant to the development of cancer because it is thought that cancer cells mis-segregate chromosomes due to errors in mitosis resulting in aneuploidy. The major pathway guarding against whole chromosome mis-segregation is the mitotic checkpoint, a cell cycle control mechanism in which the centromeres of unattached chromosomes generate an inhibitor that blocks cyclin B degradation and advance across mitosis. The antitumor drug taxol is effective by chronically activating this checkpoint. In the past year, starting from all purified components Cleveland’s efforts have reconstructed mitotic checkpoint signaling in vitro. Additionally, abnormalities in number of microtubule organizing centers (centrosomes) can promote errors in spindle formation that lead to subsequent chromosome missegregation and extra centrosomes are associated with many cancers. Like DNA, centrosomes are duplicated only once each cell cycle. The duplication process is governed by polo-like kinase 4 (Plk4). Cleveland’s recent efforts identified how centrosome over-replication is blocked: kinase-mediated, autoregulated instability of Plk4 acts to self-limit Plk4 activity so as to prevent centrosome amplification.

    Clinical Interests
    - Cancer Biology
    - Amyotrophic lateral sclerosis

    Collapse Research 
    Collapse Research Activities and Funding
    In vivo modelling and therapy development for stathmin-2 loss in TDP-43 proteinopathies
    NIH RF1NS124203Aug 1, 2021 - Jul 31, 2024
    Role: Co-Principal Investigator
    TDP-43 acetylation, phase separation, aggregation, and clearance by antibody-mediated degradation
    NIH R01NS121604Apr 1, 2021 - Mar 31, 2026
    Role: Principal Investigator
    Determining stathmin-2 function and potential as a therapeutic target in ALS/FTD
    NIH R01NS112503Apr 1, 2020 - Mar 31, 2025
    Role: Principal Investigator
    Mechanisms of chromosome segregation, aneuploidy, and tumorigenesis
    NIH R35GM122476May 1, 2017 - Feb 28, 2022
    Role: Principal Investigator
    Junior Faculty and Postdoctoral Fellows Career Development Workshop
    NIH R13GM111037Sep 15, 2014 - Aug 31, 2016
    Role: Principal Investigator
    ALS therapies and genomics for mutant TDP-43 and TLS/FUS
    NIH RC1NS069144Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Delivery of therapeutic genes in motor neuron disease
    NIH RC2NS069476Sep 30, 2009 - Aug 31, 2012
    Role: Co-Principal Investigator
    Mammalian Centromere Assembly
    NIH R01GM074150Feb 1, 2006 - Aug 31, 2018
    Role: Principal Investigator
    6TH INTERNATIONAL CONGRESS ON CELL BIOLOGY
    NIH R13CA072388Sep 30, 1996 - Sep 29, 1997
    Role: Principal Investigator
    Disease mechanism in ALS and frontotemporal dementia
    NIH R01NS027036Apr 1, 1989 - Aug 31, 2022
    Role: Principal Investigator
    Neurofilaments, SOD1 and Motor Neuron Diseases
    NIH R37NS027036Apr 1, 1989 - May 31, 2012
    Role: Principal Investigator
    MICROTUBULE REGULATION: CONTROL OF EXPRESSION OF TUBULI
    NIH K04HD000504Sep 30, 1982 - Aug 31, 1987
    Role: Principal Investigator
    Guarding the Genome: Aneuploidy and tumorigenesis
    NIH R01GM029513Jul 1, 1981 - Aug 31, 2017
    Role: Principal Investigator
    MICROTUBULE REGULATION
    NIH R37GM029513Jul 1, 1981 - Jun 30, 2004
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Frontotemporal dementia-like disease progression elicited by seeded aggregation and spread of FUS. Mol Neurodegener. 2024 Jun 11; 19(1):46. Vazquez-Sanchez S, Tilkin B, Gasset-Rosa F, Zhang S, Piol D, McAlonis-Downes M, Artates J, Govea-Perez N, Verresen Y, Guo L, Cleveland DW, Shorter J, Da Cruz S. PMID: 38862967; PMCID: PMC11165889.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    2. Frontotemporal dementia-like disease progression elicited by seeded aggregation and spread of FUS. bioRxiv. 2024 Jun 03. Vazquez-Sanchez S, Tilkin B, Gasset-Rosa F, Zhang S, Piol D, McAlonis-Downes M, Artates J, Govea-Perez N, Verresen Y, Guo L, Cleveland DW, Shorter J, Da Cruz S. PMID: 38895337; PMCID: PMC11185515.
      View in: PubMed   Mentions:
    3. A phage nucleus-associated RNA-binding protein is required for jumbo phage infection. Nucleic Acids Res. 2024 May 08; 52(8):4440-4455. Enustun E, Armbruster EG, Lee J, Zhang S, Yee BA, Malukhina K, Gu Y, Deep A, Naritomi JT, Liang Q, Aigner S, Adler BA, Cress BF, Doudna JA, Chaikeeratisak V, Cleveland DW, Ghassemian M, Bintu B, Yeo GW, Pogliano J, Corbett KD. PMID: 38554115; PMCID: PMC11077065.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    4. CK1δ/ε kinases regulate TDP-43 phosphorylation and are therapeutic targets for ALS-related TDP-43 hyperphosphorylation. Neurobiol Dis. 2024 Jun 15; 196:106516. Ko VI, Ong K, Cleveland DW, Yu H, Ravits JM. PMID: 38677657.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological hallmark of TDP-43-associated Alzheimer's disease. Acta Neuropathol. 2024 01 04; 147(1):9. Agra Almeida Quadros AR, Li Z, Wang X, Ndayambaje IS, Aryal S, Ramesh N, Nolan M, Jayakumar R, Han Y, Stillman H, Aguilar C, Wheeler HJ, Connors T, Lopez-Erauskin J, Baughn MW, Melamed Z, Beccari MS, Olmedo Martínez L, Canori M, Lee CZ, Moran L, Draper I, Kopin AS, Oakley DH, Dickson DW, Cleveland DW, Hyman BT, Das S, Ertekin-Taner N, Lagier-Tourenne C. PMID: 38175301; PMCID: PMC10766724.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    6. Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation. Nat Neurosci. 2024 Jan; 27(1):34-47. López-Erauskin J, Bravo-Hernandez M, Presa M, Baughn MW, Melamed Z, Beccari MS, Agra de Almeida Quadros AR, Arnold-Garcia O, Zuberi A, Ling K, Platoshyn O, Niño-Jara E, Ndayambaje IS, McAlonis-Downes M, Cabrera L, Artates JW, Ryan J, Hermann A, Ravits J, Bennett CF, Jafar-Nejad P, Rigo F, Marsala M, Lutz CM, Cleveland DW, Lagier-Tourenne C. PMID: 37996528; PMCID: PMC10842032.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    7. Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements. Nat Rev Genet. 2024 Mar; 25(3):196-210. Krupina K, Goginashvili A, Cleveland DW. PMID: 37938738; PMCID: PMC10922386.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    8. Molecular Graph-Based Deep Learning Algorithm Facilitates an Imaging-Based Strategy for Rapid Discovery of Small Molecules Modulating Biomolecular Condensates. J Med Chem. 2023 11 23; 66(22):15084-15093. Gao P, Zhang Q, Keely D, Cleveland DW, Ye Y, Zheng W, Shen M, Yu H. PMID: 37937963; PMCID: PMC10810226.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    9. Aberrant splicing in Huntington's disease via disrupted TDP-43 activity accompanied by altered m6A RNA modification. bioRxiv. 2023 Nov 02. Nguyen TB, Miramontes R, Chillon-Marinas C, Maimon R, Vazquez-Sanchez S, Lau AL, McClure NR, England WE, Singha M, Stocksdale JT, Jang KH, Jung S, McKnight JI, Ho LN, Faull RLM, Steffan JS, Reidling JC, Jang C, Lee G, Cleveland DW, Lagier-Tourenne C, Spitale RC, Thompson LM. PMID: 37961595; PMCID: PMC10635028.
      View in: PubMed   Mentions: 1  
    10. A phage nucleus-associated RNA-binding protein is required for jumbo phage infection. bioRxiv. 2023 Sep 22. Enustun E, Armbruster EG, Lee J, Zhang S, Yee BA, Gu Y, Deep A, Naritomi JT, Liang Q, Aigner S, Adler BA, Cress BF, Doudna JA, Chaikeeratisak V, Cleveland DW, Ghassemian M, Yeo GW, Pogliano J, Corbett KD. PMID: 37790334; PMCID: PMC10542519.
      View in: PubMed   Mentions:
    11. Mitotic tethering enables inheritance of shattered micronuclear chromosomes. Nature. 2023 Jun; 618(7967):1049-1056. Trivedi P, Steele CD, Au FKC, Alexandrov LB, Cleveland DW. PMID: 37316668; PMCID: PMC10424572.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    12. Chromosomal fragile site breakage by EBV-encoded EBNA1 at clustered repeats. Nature. 2023 04; 616(7957):504-509. Li JSZ, Abbasi A, Kim DH, Lippman SM, Alexandrov LB, Cleveland DW. PMID: 37046091; PMCID: PMC10328181.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    13. GOLGA8 increases bulk antisense oligonucleotide uptake and activity in mammalian cells. Mol Ther Nucleic Acids. 2023 Jun 13; 32:289-301. McMahon MA, Rahdar M, Mukhopadhyay S, Bui HH, Hart C, Damle S, Courtney M, Baughn MW, Cleveland DW, Bennett CF. PMID: 37096163; PMCID: PMC10122063.
      View in: PubMed   Mentions: 1  
    14. Mechanism of STMN2 cryptic splice-polyadenylation and its correction for TDP-43 proteinopathies. Science. 2023 03 17; 379(6637):1140-1149. Baughn MW, Melamed Z, López-Erauskin J, Beccari MS, Ling K, Zuberi A, Presa M, Gonzalo-Gil E, Maimon R, Vazquez-Sanchez S, Chaturvedi S, Bravo-Hernández M, Taupin V, Moore S, Artates JW, Acks E, Ndayambaje IS, Agra de Almeida Quadros AR, Jafar-Nejad P, Rigo F, Bennett CF, Lutz C, Lagier-Tourenne C, Cleveland DW. PMID: 36927019; PMCID: PMC10148063.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    15. A reference human induced pluripotent stem cell line for large-scale collaborative studies. Cell Stem Cell. 2022 12 01; 29(12):1685-1702.e22. Pantazis CB, Yang A, Lara E, McDonough JA, Blauwendraat C, Peng L, Oguro H, Kanaujiya J, Zou J, Sebesta D, Pratt G, Cross E, Blockwick J, Buxton P, Kinner-Bibeau L, Medura C, Tompkins C, Hughes S, Santiana M, Faghri F, Nalls MA, Vitale D, Ballard S, Qi YA, Ramos DM, Anderson KM, Stadler J, Narayan P, Papademetriou J, Reilly L, Nelson MP, Aggarwal S, Rosen LU, Kirwan P, Pisupati V, Coon SL, Scholz SW, Priebe T, Öttl M, Dong J, Meijer M, Janssen LJM, Lourenco VS, van der Kant R, Crusius D, Paquet D, Raulin AC, Bu G, Held A, Wainger BJ, Gabriele RMC, Casey JM, Wray S, Abu-Bonsrah D, Parish CL, Beccari MS, Cleveland DW, Li E, Rose IVL, Kampmann M, Calatayud Aristoy C, Verstreken P, Heinrich L, Chen MY, Schüle B, Dou D, Holzbaur ELF, Zanellati MC, Basundra R, Deshmukh M, Cohen S, Khanna R, Raman M, Nevin ZS, Matia M, Van Lent J, Timmerman V, Conklin BR, Johnson Chase K, Zhang K, Funes S, Bosco DA, Erlebach L, Welzer M, Kronenberg-Versteeg D, Lyu G, Arenas E, Coccia E, Sarrafha L, Ahfeldt T, Marioni JC, Skarnes WC, Cookson MR, Ward ME, Merkle FT. PMID: 36459969; PMCID: PMC9782786.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    16. Comprehensive evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of C9orf72 disease. Proc Natl Acad Sci U S A. 2022 12 06; 119(49):e2123487119. Jambeau M, Meyer KD, Hruska-Plochan M, Tabet R, Lee CZ, Ray-Soni A, Aguilar C, Savage K, Mishra N, Cavegn N, Borter P, Lin CC, Jansen-West KR, Jiang J, Freyermuth F, Li N, De Rossi P, Pérez-Berlanga M, Jiang X, Daughrity LM, Pereira J, Narayanan S, Gu Y, Dhokai S, Dalkilic-Liddle I, Maniecka Z, Weber J, Workman M, McAlonis-Downes M, Berezovski E, Zhang YJ, Berry J, Wainger BJ, Kankel MW, Rushe M, Hock C, Nitsch RM, Cleveland DW, Petrucelli L, Gendron TF, Montrasio F, Grimm J, Polymenidou M, Lagier-Tourenne C. PMID: 36454749; PMCID: PMC9894253.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    17. Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition. Nat Cell Biol. 2022 09; 24(9):1378-1393. Lu S, Hu J, Arogundade OA, Goginashvili A, Vazquez-Sanchez S, Diedrich JK, Gu J, Blum J, Oung S, Ye Q, Yu H, Ravits J, Liu C, Yates JR, Cleveland DW. PMID: 36075972; PMCID: PMC9872726.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    18. Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis. Acta Neuropathol. 2021 12; 142(6):985-1001. Diaz-Garcia S, Ko VI, Vazquez-Sanchez S, Chia R, Arogundade OA, Rodriguez MJ, Traynor BJ, Cleveland D, Ravits J. PMID: 34618203; PMCID: PMC8568872.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    19. Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation. Mol Neurodegener. 2021 09 06; 16(1):61. Sanjuan-Ruiz I, Govea-Perez N, McAlonis-Downes M, Dieterle S, Megat S, Dirrig-Grosch S, Picchiarelli G, Piol D, Zhu Q, Myers B, Lee CZ, Cleveland DW, Lagier-Tourenne C, Da Cruz S, Dupuis L. PMID: 34488813; PMCID: PMC8419956.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    20. Transient genomic instability drives tumorigenesis through accelerated clonal evolution. Genes Dev. 2021 08 01; 35(15-16):1093-1108. Shoshani O, Bakker B, de Haan L, Tijhuis AE, Wang Y, Kim DH, Maldonado M, Demarest MA, Artates J, Zhengyu O, Mark A, Wardenaar R, Sasik R, Spierings DCJ, Vitre B, Fisch K, Foijer F, Cleveland DW. PMID: 34266887; PMCID: PMC8336898.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    21. Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB. Nat Neurosci. 2021 08; 24(8):1089-1099. Maimon R, Chillon-Marinas C, Snethlage CE, Singhal SM, McAlonis-Downes M, Ling K, Rigo F, Bennett CF, Da Cruz S, Hnasko TS, Muotri AR, Cleveland DW. PMID: 34083786; PMCID: PMC8338913.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    22. Immune evasion in HPV- head and neck precancer-cancer transition is driven by an aneuploid switch involving chromosome 9p loss. Proc Natl Acad Sci U S A. 2021 05 11; 118(19). William WN, Zhao X, Bianchi JJ, Lin HY, Cheng P, Lee JJ, Carter H, Alexandrov LB, Abraham JP, Spetzler DB, Dubinett SM, Cleveland DW, Cavenee W, Davoli T, Lippman SM. PMID: 33952700; PMCID: PMC8126856.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    23. Novel STMN2 Variant Linked to Amyotrophic Lateral Sclerosis Risk and Clinical Phenotype. Front Aging Neurosci. 2021; 13:658226. Theunissen F, Anderton RS, Mastaglia FL, Flynn LL, Winter SJ, James I, Bedlack R, Hodgetts S, Fletcher S, Wilton SD, Laing NG, MacShane M, Needham M, Saunders A, Mackay-Sim A, Melamed Z, Ravits J, Cleveland DW, Akkari PA. PMID: 33841129; PMCID: PMC8033025.
      View in: PubMed   Mentions: 24  
    24. Publisher Correction: Chromothripsis drives the evolution of gene amplification in cancer. Nature. 2021 Mar; 591(7850):E19. Shoshani O, Brunner SF, Yaeger R, Ly P, Nechemia-Arbely Y, Kim DH, Fang R, Castillon GA, Yu M, Li JSZ, Sun Y, Ellisman MH, Ren B, Campbell PJ, Cleveland DW. PMID: 33649505.
      View in: PubMed   Mentions: 4     Fields:    
    25. Causes and consequences of micronuclei. Curr Opin Cell Biol. 2021 06; 70:91-99. Krupina K, Goginashvili A, Cleveland DW. PMID: 33610905; PMCID: PMC8119331.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    26. The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein. Nat Commun. 2021 01 21; 12(1):502. Lu S, Ye Q, Singh D, Cao Y, Diedrich JK, Yates JR, Villa E, Cleveland DW, Corbett KD. PMID: 33479198; PMCID: PMC7820290.
      View in: PubMed   Mentions: 225     Fields:    Translation:HumansCells
    27. Chromothripsis drives the evolution of gene amplification in cancer. Nature. 2021 03; 591(7848):137-141. Shoshani O, Brunner SF, Yaeger R, Ly P, Nechemia-Arbely Y, Kim DH, Fang R, Castillon GA, Yu M, Li JSZ, Sun Y, Ellisman MH, Ren B, Campbell PJ, Cleveland DW. PMID: 33361815; PMCID: PMC7933129.
      View in: PubMed   Mentions: 182     Fields:    Translation:HumansCells
    28. HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells. Science. 2021 02 05; 371(6529). Yu H, Lu S, Gasior K, Singh D, Vazquez-Sanchez S, Tapia O, Toprani D, Beccari MS, Yates JR, Da Cruz S, Newby JM, Lafarga M, Gladfelter AS, Villa E, Cleveland DW. PMID: 33335017; PMCID: PMC8286096.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansAnimalsCells
    29. Antisense Drugs Make Sense for Neurological Diseases. Annu Rev Pharmacol Toxicol. 2021 01 06; 61:831-852. Bennett CF, Kordasiewicz HB, Cleveland DW. PMID: 33035446; PMCID: PMC8682074.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    30. Author Correction: Reversing a model of Parkinson's disease with in situ converted nigral neurons. Nature. 2020 Aug; 584(7820):E17. Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, Zhang X, Xue Y, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD. PMID: 32724206.
      View in: PubMed   Mentions: 3     Fields:    
    31. The SARS-CoV-2 Nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein. bioRxiv. 2020 Jul 31. Lu S, Ye Q, Singh D, Villa E, Cleveland DW, Corbett KD. PMID: 32766587; PMCID: PMC7402048.
      View in: PubMed   Mentions:
    32. Reversing a model of Parkinson's disease with in situ converted nigral neurons. Nature. 2020 06; 582(7813):550-556. Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, Zhang X, Xue Y, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD. PMID: 32581380; PMCID: PMC7521455.
      View in: PubMed   Mentions: 210     Fields:    Translation:HumansAnimalsCells
    33. ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS. Neuron. 2020 04 22; 106(2):354. López-Erauskin J, Tadokoro T, Baughn MW, Myers B, McAlonis-Downes M, Chillon-Marinas C, Asiaban JN, Artates J, Bui AT, Vetto AP, Lee SK, Le AV, Sun Y, Jambeau M, Boubaker J, Swing D, Qiu J, Hicks GG, Ouyang Z, Fu XD, Tessarollo L, Ling SC, Parone PA, Shaw CE, Marsala M, Lagier-Tourenne C, Cleveland DW, Da Cruz S. PMID: 32325059; PMCID: PMC7184958.
      View in: PubMed   Mentions: 5     Fields:    
    34. Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72. Nat Neurosci. 2020 05; 23(5):615-624. Zhu Q, Jiang J, Gendron TF, McAlonis-Downes M, Jiang L, Taylor A, Diaz Garcia S, Ghosh Dastidar S, Rodriguez MJ, King P, Zhang Y, La Spada AR, Xu H, Petrucelli L, Ravits J, Da Cruz S, Lagier-Tourenne C, Cleveland DW. PMID: 32284607; PMCID: PMC7384305.
      View in: PubMed   Mentions: 118     Fields:    Translation:AnimalsCells
    35. Gene expression regulated by RNA stability. Science. 2020 01 03; 367(6473):29. Shoshani O, Cleveland DW. PMID: 31896707.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    36. Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS. Nat Med. 2020 01; 26(1):118-130. Bravo-Hernandez M, Tadokoro T, Navarro MR, Platoshyn O, Kobayashi Y, Marsala S, Miyanohara A, Juhas S, Juhasova J, Skalnikova H, Tomori Z, Vanicky I, Studenovska H, Proks V, Chen P, Govea-Perez N, Ditsworth D, Ciacci JD, Gao S, Zhu W, Ahrens ET, Driscoll SP, Glenn TD, McAlonis-Downes M, Da Cruz S, Pfaff SL, Kaspar BK, Cleveland DW, Marsala M. PMID: 31873312; PMCID: PMC8171115.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    37. CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation. Neuron. 2019 12 04; 104(5):885-898.e8. Cheng W, Wang S, Zhang Z, Morgens DW, Hayes LR, Lee S, Portz B, Xie Y, Nguyen BV, Haney MS, Yan S, Dong D, Coyne AN, Yang J, Xian F, Cleveland DW, Qiu Z, Rothstein JD, Shorter J, Gao FB, Bassik MC, Sun S. PMID: 31587919; PMCID: PMC6895427.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    38. Antisense Oligonucleotide Therapies for Neurodegenerative Diseases. Annu Rev Neurosci. 2019 07 08; 42:385-406. Bennett CF, Krainer AR, Cleveland DW. PMID: 31283897; PMCID: PMC7427431.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansAnimals
    39. BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules. Cell Res. 2019 07; 29(7):562-578. Huang Y, Lin L, Liu X, Ye S, Yao PY, Wang W, Yang F, Gao X, Li J, Zhang Y, Zhang J, Yang Z, Liu X, Yang Z, Zang J, Teng M, Wang Z, Ruan K, Ding X, Li L, Cleveland DW, Zhang R, Yao X. PMID: 31201382; PMCID: PMC6796941.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    40. DNA replication acts as an error correction mechanism to maintain centromere identity by restricting CENP-A to centromeres. Nat Cell Biol. 2019 06; 21(6):743-754. Nechemia-Arbely Y, Miga KH, Shoshani O, Aslanian A, McMahon MA, Lee AY, Fachinetti D, Yates JR, Ren B, Cleveland DW. PMID: 31160708; PMCID: PMC7015266.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    41. Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment. J Clin Invest. 2019 05 21; 129(8):3103-3120. Jiang LL, Zhu B, Zhao Y, Li X, Liu T, Pina-Crespo J, Zhou L, Xu W, Rodriguez MJ, Yu H, Cleveland DW, Ravits J, Da Cruz S, Long T, Zhang D, Huang TY, Xu H. PMID: 31112137; PMCID: PMC6668683.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    42. Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death. Neuron. 2019 04 17; 102(2):339-357.e7. Gasset-Rosa F, Lu S, Yu H, Chen C, Melamed Z, Guo L, Shorter J, Da Cruz S, Cleveland DW. PMID: 30853299; PMCID: PMC6548321.
      View in: PubMed   Mentions: 210     Fields:    Translation:HumansAnimalsCells
    43. Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements. Nat Genet. 2019 04; 51(4):705-715. Ly P, Brunner SF, Shoshani O, Kim DH, Lan W, Pyntikova T, Flanagan AM, Behjati S, Page DC, Campbell PJ, Cleveland DW. PMID: 30833795; PMCID: PMC6441390.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    44. Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis. Elife. 2019 02 12; 8. Ling SC, Dastidar SG, Tokunaga S, Ho WY, Lim K, Ilieva H, Parone PA, Tyan SH, Tse TM, Chang JC, Platoshyn O, Bui NB, Bui A, Vetto A, Sun S, McAlonis-Downes M, Han JS, Swing D, Kapeli K, Yeo GW, Tessarollo L, Marsala M, Shaw CE, Tucker-Kellogg G, La Spada AR, Lagier-Tourenne C, Da Cruz S, Cleveland DW. PMID: 30747709; PMCID: PMC6389288.
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    330. CENP-E is a putative kinetochore motor that accumulates just before mitosis. Nature. 1992 Oct 08; 359(6395):536-9. Yen TJ, Li G, Schaar BT, Szilak I, Cleveland DW. PMID: 1406971.
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    331. Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a > 20S degradation complex. Genes Dev. 1992 Oct; 6(10):1927-39. Savant-Bhonsale S, Cleveland DW. PMID: 1398070.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    332. Gamma-tubulin is a centrosomal protein required for cell cycle-dependent microtubule nucleation. Nature. 1992 Mar 05; 356(6364):80-3. Joshi HC, Palacios MJ, McNamara L, Cleveland DW. PMID: 1538786.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimalsCells
    333. Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis. J Cell Biol. 1992 Mar; 116(6):1395-408. Compton DA, Szilak I, Cleveland DW. PMID: 1541636; PMCID: PMC2289377.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    334. Physical evidence for cotranslational regulation of beta-tubulin mRNA degradation. Mol Cell Biol. 1992 Feb; 12(2):791-9. Theodorakis NG, Cleveland DW. PMID: 1732744; PMCID: PMC364304.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    335. Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein. J Cell Biol. 1991 Dec; 115(6):1639-50. Gill SR, Schroer TA, Szilak I, Steuer ER, Sheetz MP, Cleveland DW. PMID: 1836789; PMCID: PMC2289205.
      View in: PubMed   Mentions: 187     Fields:    Translation:AnimalsCells
    336. Slow axonal transport models come full circle: evidence that microtubule sliding mediates axon elongation and tubulin transport. Cell. 1991 Nov 01; 67(3):453-6. Cleveland DW, Hoffman PN. PMID: 1718604.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    337. Neuronal and glial cytoskeletons. Curr Opin Neurobiol. 1991 Oct; 1(3):346-53. Cleveland DW, Hoffman PN. PMID: 1821676.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    338. CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase. EMBO J. 1991 May; 10(5):1245-54. Yen TJ, Compton DA, Wise D, Zinkowski RP, Brinkley BR, Earnshaw WC, Cleveland DW. PMID: 2022189; PMCID: PMC452779.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansCells
    339. Identification of novel centromere/kinetochore-associated proteins using monoclonal antibodies generated against human mitotic chromosome scaffolds. J Cell Biol. 1991 Mar; 112(6):1083-97. Compton DA, Yen TJ, Cleveland DW. PMID: 1999466; PMCID: PMC2288900.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    340. Ability of the c-mos product to associate with and phosphorylate tubulin. Science. 1991 Feb 08; 251(4994):671-5. Zhou RP, Oskarsson M, Paules RS, Schulz N, Cleveland D, Vande Woude GF. PMID: 1825142.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    341. Involvement of neurofilaments in the radial growth of axons. J Cell Sci Suppl. 1991; 15:85-95. Cleveland DW, Monteiro MJ, Wong PC, Gill SR, Gearhart JD, Hoffman PN. PMID: 1824110.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    342. Characterization of dominant and recessive assembly-defective mutations in mouse neurofilament NF-M. J Cell Biol. 1990 Nov; 111(5 Pt 1):1987-2003. Wong PC, Cleveland DW. PMID: 2121743; PMCID: PMC2116320.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    343. Assembly properties of dominant and recessive mutations in the small mouse neurofilament (NF-L) subunit. J Cell Biol. 1990 Nov; 111(5 Pt 1):2005-19. Gill SR, Wong PC, Monteiro MJ, Cleveland DW. PMID: 2121744; PMCID: PMC2116331.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    344. Expression of NF-L in both neuronal and nonneuronal cells of transgenic mice: increased neurofilament density in axons without affecting caliber. J Cell Biol. 1990 Oct; 111(4):1543-57. Monteiro MJ, Hoffman PN, Gearhart JD, Cleveland DW. PMID: 2120242; PMCID: PMC2116226.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    345. Use of molecular cloning methods to map the distribution of epitopes on topoisomerase I (Scl-70) recognized by sera of scleroderma patients. Arthritis Rheum. 1990 Oct; 33(10):1501-11. D'Arpa P, White-Cooper H, Cleveland DW, Rothfield NF, Earnshaw WC. PMID: 1699543.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    346. Solid adenoid cystic carcinoma of the maxilla. Oral Surg Oral Med Oral Pathol. 1990 Apr; 69(4):470-8. Cleveland D, Abrams AM, Melrose RJ, Handlers JP. PMID: 2158031.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    347. Lung abscess secondary to xanthogranulomatous pyelonephritis. Thorax. 1990 Apr; 45(4):297-9. Pandya K, Wilcox J, Khaw H, Cleveland D, Sharma OP. PMID: 2356557; PMCID: PMC473778.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    348. Tubulin site interpretation. Nature. 1990 Mar 29; 344(6265):389. Cleveland DW, Joshi HC, Murphy DB. PMID: 2138712.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    349. Microtubule MAPping. Cell. 1990 Mar 09; 60(5):701-2. Cleveland DW. PMID: 2107023.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    350. A rapidly rearranging retrotransposon within the miniexon gene locus of Crithidia fasciculata. Mol Cell Biol. 1990 Feb; 10(2):615-24. Gabriel A, Yen TJ, Schwartz DC, Smith CL, Boeke JD, Sollner-Webb B, Cleveland DW. PMID: 2153919; PMCID: PMC360853.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    351. Diversity among tubulin subunits: toward what functional end? Cell Motil Cytoskeleton. 1990; 16(3):159-63. Joshi HC, Cleveland DW. PMID: 2194680.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    352. The expression and posttranslational modification of a neuron-specific beta-tubulin isotype during chick embryogenesis. Cell Motil Cytoskeleton. 1990; 17(2):118-32. Lee MK, Tuttle JB, Rebhun LI, Cleveland DW, Frankfurter A. PMID: 2257630.
      View in: PubMed   Mentions: 185     Fields:    Translation:AnimalsCells
    353. In vivo discrimination among beta-tubulin isotypes: selective degradation of a type IV beta-tubulin isotype following overexpression in cultured animal cells. New Biol. 1990 Jan; 2(1):66-76. Sisodia SS, Gay DA, Cleveland DW. PMID: 2078553.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    354. Gene regulation through messenger RNA stability. Curr Opin Cell Biol. 1989 Dec; 1(6):1148-53. Cleveland DW. PMID: 2699801.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    355. Multiple determinants of eukaryotic mRNA stability. New Biol. 1989 Nov; 1(2):121-6. Cleveland DW, Yen TJ. PMID: 2518709.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    356. Autoregulatory control of beta-tubulin mRNA stability is linked to translation elongation. Proc Natl Acad Sci U S A. 1989 Aug; 86(15):5763-7. Gay DA, Sisodia SS, Cleveland DW. PMID: 2762294; PMCID: PMC297710.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    357. Differential utilization of beta-tubulin isotypes in differentiating neurites. J Cell Biol. 1989 Aug; 109(2):663-73. Joshi HC, Cleveland DW. PMID: 2503525; PMCID: PMC2115728.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    358. Expression of NF-L and NF-M in fibroblasts reveals coassembly of neurofilament and vimentin subunits. J Cell Biol. 1989 Feb; 108(2):579-93. Monteiro MJ, Cleveland DW. PMID: 2493000; PMCID: PMC2115435.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    359. Autoregulated control of tubulin synthesis in animal cells. Curr Opin Cell Biol. 1989 Feb; 1(1):10-4. Cleveland DW. PMID: 2629858.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    360. Use of DNA transfection to analyze gene regulation and function in animal cells: dissection of the tubulin multigene family. Cell Motil Cytoskeleton. 1989; 14(1):147-55. Cleveland DW. PMID: 2684421.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    361. Autoregulated instability of tubulin mRNAs: a novel eukaryotic regulatory mechanism. Trends Biochem Sci. 1988 Sep; 13(9):339-43. Cleveland DW. PMID: 3072712.
      View in: PubMed   Mentions: 45     Fields:    
    362. Autoregulated instability of beta-tubulin mRNAs by recognition of the nascent amino terminus of beta-tubulin. Nature. 1988 Aug 18; 334(6183):580-5. Yen TJ, Machlin PS, Cleveland DW. PMID: 3405308.
      View in: PubMed   Mentions: 106     Fields:    Translation:Cells
    363. Neurofilament and tubulin expression recapitulates the developmental program during axonal regeneration: induction of a specific beta-tubulin isotype. Proc Natl Acad Sci U S A. 1988 Jun; 85(12):4530-3. Hoffman PN, Cleveland DW. PMID: 3132717; PMCID: PMC280464.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    364. A survey of the alpha-tubulin gene family in chicken: unexpected sequence heterogeneity in the polypeptides encoded by five expressed genes. EMBO J. 1988 Apr; 7(4):931-40. Pratt LF, Cleveland DW. PMID: 3267229; PMCID: PMC454418.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    365. cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7-kDa carboxyl-terminal fragment. Proc Natl Acad Sci U S A. 1988 Apr; 85(8):2543-7. D'Arpa P, Machlin PS, Ratrie H, Rothfield NF, Cleveland DW, Earnshaw WC. PMID: 2833744; PMCID: PMC280033.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    366. Autoregulated changes in stability of polyribosome-bound beta-tubulin mRNAs are specified by the first 13 translated nucleotides. Mol Cell Biol. 1988 Mar; 8(3):1224-35. Yen TJ, Gay DA, Pachter JS, Cleveland DW. PMID: 2835666; PMCID: PMC363267.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    367. Sequence of chicken c beta 7 tubulin. Analysis of a complete set of vertebrate beta-tubulin isotypes. J Mol Biol. 1988 Feb 05; 199(3):439-46. Monteiro MJ, Cleveland DW. PMID: 3351937.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    368. Evidence of discontinuous transcription in the trypanosomatid Crithidia fasciculata. J Biol Chem. 1987 Nov 25; 262(33):16192-9. Gabriel A, Sisodia SS, Cleveland DW. PMID: 3680249.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    369. In vivo coassembly of a divergent beta-tubulin subunit (c beta 6) into microtubules of different function. J Cell Biol. 1987 Nov; 105(5):2179-90. Joshi HC, Yen TJ, Cleveland DW. PMID: 3316249; PMCID: PMC2114845.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    370. Autoregulation of tubulin expression is achieved through specific degradation of polysomal tubulin mRNAs. Cell. 1987 Oct 23; 51(2):283-92. Pachter JS, Yen TJ, Cleveland DW. PMID: 2444342.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    371. The sequence and expression of the divergent beta-tubulin in chicken erythrocytes. J Biol Chem. 1987 Oct 15; 262(29):14305-12. Murphy DB, Wallis KT, Machlin PS, Ratrie H, Cleveland DW. PMID: 2888766.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    372. Specificity of RNA maturation pathways: RNAs transcribed by RNA polymerase III are not substrates for splicing or polyadenylation. Mol Cell Biol. 1987 Oct; 7(10):3602-12. Sisodia SS, Sollner-Webb B, Cleveland DW. PMID: 3683396; PMCID: PMC368014.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    373. In vivo microtubules are copolymers of available beta-tubulin isotypes: localization of each of six vertebrate beta-tubulin isotypes using polyclonal antibodies elicited by synthetic peptide antigens. J Cell Biol. 1987 Oct; 105(4):1707-20. Lopata MA, Cleveland DW. PMID: 3312237; PMCID: PMC2114651.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    374. Sequences that confer beta-tubulin autoregulation through modulated mRNA stability reside within exon 1 of a beta-tubulin mRNA. Cell. 1987 Aug 28; 50(5):671-9. Gay DA, Yen TJ, Lau JT, Cleveland DW. PMID: 3621343.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    375. Analysis of anticentromere autoantibodies using cloned autoantigen CENP-B. Proc Natl Acad Sci U S A. 1987 Jul; 84(14):4979-83. Earnshaw WC, Machlin PS, Bordwell BJ, Rothfield NF, Cleveland DW. PMID: 2440036; PMCID: PMC305230.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    376. Neurofilament gene expression: a major determinant of axonal caliber. Proc Natl Acad Sci U S A. 1987 May; 84(10):3472-6. Hoffman PN, Cleveland DW, Griffin JW, Landes PW, Cowan NJ, Price DL. PMID: 3472217; PMCID: PMC304893.
      View in: PubMed   Mentions: 189     Fields:    Translation:AnimalsCells
    377. Molecular cloning of cDNA for CENP-B, the major human centromere autoantigen. J Cell Biol. 1987 Apr; 104(4):817-29. Earnshaw WC, Sullivan KF, Machlin PS, Cooke CA, Kaiser DA, Pollard TD, Rothfield NF, Cleveland DW. PMID: 2435739; PMCID: PMC2114438.
      View in: PubMed   Mentions: 174     Fields:    Translation:HumansCells
    378. A combination of RNase H and S1 nuclease circumvents an artefact inherent to conventional S1 analysis of RNA splicing. Nucleic Acids Res. 1987 Mar 11; 15(5):1995-2011. Sisodia SS, Cleveland DW, Sollner-Webb B. PMID: 3031584; PMCID: PMC340613.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    379. The multitubulin hypothesis revisited: what have we learned? J Cell Biol. 1987 Mar; 104(3):381-3. Cleveland DW. PMID: 3546332; PMCID: PMC2114543.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    380. A divergent testis-specific alpha-tubulin isotype that does not contain a coded C-terminal tyrosine. Mol Cell Biol. 1987 Jan; 7(1):552-5. Pratt LF, Okamura S, Cleveland DW. PMID: 3561402; PMCID: PMC365103.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    381. Sequence and expression of the chicken beta 5- and beta 4-tubulin genes define a pair of divergent beta-tubulins with complementary patterns of expression. Mol Cell Biol. 1986 Dec; 6(12):4409-18. Sullivan KF, Havercroft JC, Machlin PS, Cleveland DW. PMID: 3025656; PMCID: PMC367223.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    382. Sequence and expression of the chicken beta 3 tubulin gene. A vertebrate testis beta-tubulin isotype. J Biol Chem. 1986 Oct 05; 261(28):13317-22. Sullivan KF, Machlin PS, Ratrie H, Cleveland DW. PMID: 3759966.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    383. RNA polymerase specificity of mRNA production and enhancer action. Proc Natl Acad Sci U S A. 1986 Sep; 83(18):6677-81. Lopata MA, Cleveland DW, Sollner-Webb B. PMID: 3462718; PMCID: PMC386572.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    384. Identification of conserved isotype-defining variable region sequences for four vertebrate beta tubulin polypeptide classes. Proc Natl Acad Sci U S A. 1986 Jun; 83(12):4327-31. Sullivan KF, Cleveland DW. PMID: 3459176; PMCID: PMC323725.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
    385. Reconstruction of tubulin gene regulation in cultured mammalian cells. Ann N Y Acad Sci. 1986; 466:75-88. Lau JT, Pittenger MF, Havercroft JC, Cleveland DW. PMID: 3460447.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    386. Retention of autoregulatory control of tubulin synthesis in cytoplasts: demonstration of a cytoplasmic mechanism that regulates the level of tubulin expression. J Cell Biol. 1985 Nov; 101(5 Pt 1):1941-52. Pittenger MF, Cleveland DW. PMID: 4055901; PMCID: PMC2113971.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    387. Apparent gene conversion between beta-tubulin genes yields multiple regulatory pathways for a single beta-tubulin polypeptide isotype. Mol Cell Biol. 1985 Sep; 5(9):2454-65. Sullivan KF, Lau JT, Cleveland DW. PMID: 3837190; PMCID: PMC366973.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    388. Reconstruction of appropriate tubulin and actin gene regulation after transient transfection of cloned beta-tubulin and beta-actin genes. Mol Cell Biol. 1985 Jul; 5(7):1611-20. Lau JT, Pittenger MF, Cleveland DW. PMID: 4022009; PMCID: PMC367279.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    389. Molecular biology and genetics of tubulin. Annu Rev Biochem. 1985; 54:331-65. Cleveland DW, Sullivan KF. PMID: 3896122.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    390. Programmed expression of beta-tubulin genes during development and differentiation of the chicken. J Cell Biol. 1984 Dec; 99(6):1927-35. Havercroft JC, Cleveland DW. PMID: 6094589; PMCID: PMC2113537.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    391. Sequence of a highly divergent beta tubulin gene reveals regional heterogeneity in the beta tubulin polypeptide. J Cell Biol. 1984 Nov; 99(5):1754-60. Sullivan KF, Cleveland DW. PMID: 6490718; PMCID: PMC2113369.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    392. High level transient expression of a chloramphenicol acetyl transferase gene by DEAE-dextran mediated DNA transfection coupled with a dimethyl sulfoxide or glycerol shock treatment. Nucleic Acids Res. 1984 Jul 25; 12(14):5707-17. Lopata MA, Cleveland DW, Sollner-Webb B. PMID: 6589587; PMCID: PMC320025.
      View in: PubMed   Mentions: 270     Fields:    Translation:AnimalsCells
    393. Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions. Mol Cell Biol. 1983 Oct; 3(10):1738-45. Cowan NJ, Dobner PR, Fuchs EV, Cleveland DW. PMID: 6646120; PMCID: PMC370035.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    394. Elevation of tubulin levels by microinjection suppresses new tubulin synthesis. Nature. 1983 Oct 20-26; 305(5936):738-40. Cleveland DW, Pittenger MF, Feramisco JR. PMID: 6633643.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    395. The tubulins: from DNA to RNA to protein and back again. Cell. 1983 Sep; 34(2):330-2. Cleveland DW. PMID: 6193888.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    396. Is apparent autoregulatory control of tubulin synthesis nontranscriptionally regulated? J Cell Biol. 1983 Sep; 97(3):919-24. Cleveland DW, Havercroft JC. PMID: 6885926; PMCID: PMC2112582.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    397. Glyceraldehyde 3-phosphate dehydrogenase protein and mRNA are both differentially expressed in adult chickens but not chick embryos. Nucleic Acids Res. 1983 May 25; 11(10):3301-15. Milner RJ, Brow MD, Cleveland DW, Shinnick TM, Sutcliffe JG. PMID: 6687938; PMCID: PMC325964.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    398. Four unique genes required for beta tubulin expression in vertebrates. Cell. 1983 Mar; 32(3):713-24. Lopata MA, Havercroft JC, Chow LT, Cleveland DW. PMID: 6831558.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    399. Autoregulatory control of expression of alpha and beta tubulin. J Submicrosc Cytol. 1983 Jan; 15(1):353-8. Cleveland DW, Pittenger MF, Lopata MA. PMID: 6188853.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    400. Treadmilling of tubulin and actin. Cell. 1982 Apr; 28(4):689-91. Cleveland DW. PMID: 7046949.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    401. Autoregulatory control of the expression of alpha- and beta-tubulins: implications for microtubule assembly. Cold Spring Harb Symp Quant Biol. 1982; 46 Pt 1:171-83. Cleveland D, Kirschner M. PMID: 6286212.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    402. Probing the function of the eucaryotic 5' cap structure by using a monoclonal antibody directed against cap-binding proteins. Cell. 1981 Dec; 27(3 Pt 2):563-72. Sonenberg N, Guertin D, Cleveland D, Trachsel H. PMID: 6101207.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    403. Two distinct classes of keratin genes and their evolutionary significance. Cell. 1981 Nov; 27(1 Pt 2):75-84. Fuchs EV, Coppock SM, Green H, Cleveland DW. PMID: 6173133.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    404. Unpolymerized tubulin modulates the level of tubulin mRNAs. Cell. 1981 Aug; 25(2):537-46. Cleveland DW, Lopata MA, Sherline P, Kirschner MW. PMID: 6116546.
      View in: PubMed   Mentions: 129     Fields:    Translation:AnimalsCells
    405. Multiple alpha and beta tubulin genes represent unlinked and dispersed gene families. J Biol Chem. 1981 Mar 25; 256(6):3130-4. Cleveland DW, Hughes SH, Stubblefield E, Kirschner MW, Varmus HE. PMID: 6259149.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    406. Nucleotide and corresponding amino acid sequences encoded by alpha and beta tubulin mRNAs. Nature. 1981 Feb 19; 289(5799):650-5. Valenzuela P, Quiroga M, Zaldivar J, Rutter WJ, Kirschner MW, Cleveland DW. PMID: 7464932.
      View in: PubMed   Mentions: 115     Fields:    Translation:AnimalsCells
    407. A dispersed multigene family encoding tubulin in Drosophila melanogaster. Cell. 1980 Dec; 22(3):845-54. Sánchez F, Natzle JE, Cleveland DW, Kirschner MW, McCarthy BJ. PMID: 6780200.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    408. Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. Cell. 1980 May; 20(1):95-105. Cleveland DW, Lopata MA, MacDonald RJ, Cowan NJ, Rutter WJ, Kirschner MW. PMID: 6893015.
      View in: PubMed   Mentions: 510     Fields:    Translation:HumansAnimals
    409. Conservation of microtubule associated proteins. Isolation and characterization of tau and the high molecular weight microtubule associated protein from chicken brain and from mouse fibroblasts and comparison to the corresponding mammalian brain proteins. J Biol Chem. 1979 Dec 25; 254(24):12670-8. Cleveland DW, Spiegelman BM, Kirschner MW. PMID: 227904.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    410. Isolation of separate mRNAs for alpha- and beta-tubulin and characterization of the corresponding in vitro translation products. Cell. 1978 Nov; 15(3):1021-31. Cleveland DW, Kirschner MW, Cowan NJ. PMID: 728983.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    411. Intracellular localization of the high molecular weight microtubule accessory protein by indirect immunofluorescence. J Cell Biol. 1978 Mar; 76(3):781-6. Connolly JA, Kalnins VI, Cleveland DW, Kirschner MW. PMID: 344329; PMCID: PMC2110001.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    412. Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin. J Mol Biol. 1977 Oct 25; 116(2):207-25. Cleveland DW, Hwo SY, Kirschner MW. PMID: 599557.
      View in: PubMed   Mentions: 282     Fields:    Translation:Cells
    413. Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly. J Mol Biol. 1977 Oct 25; 116(2):227-47. Cleveland DW, Hwo SY, Kirschner MW. PMID: 146092.
      View in: PubMed   Mentions: 256     Fields:    Translation:Cells
    414. Immunoflourescent staining of cytoplasmic and spindle microtubules in mouse fibroblasts with antibody to tau protein. Proc Natl Acad Sci U S A. 1977 Jun; 74(6):2437-40. Connolly JA, Kalnins VI, Cleveland DW, Kirschner MW. PMID: 329285; PMCID: PMC432187.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    415. Tubulin requires tau for growth onto microtubule initiating sites. Proc Natl Acad Sci U S A. 1976 Nov; 73(11):4070-4. Witman GB, Cleveland DW, Weingarten MD, Kirschner MW. PMID: 1069293; PMCID: PMC431332.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
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