Gabriela G Loots

Title(s)Professor, MED: Orthopaedic Surgery
SchoolSchool of Medicine
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Single cell RNA sequencing reveals a shift in cell function and maturation of endogenous and infiltrating cell types in response to acute intervertebral disc injury. bioRxiv. 2024 Aug 10. Clayton SW, Sebastian A, Wilson SP, Hum NR, Walk RE, Easson GWD, Vaidya R, Broz KS, Loots GG, Tang SY. PMID: 39149307; PMCID: PMC11326235.
      View in: PubMed   Mentions:
    2. Simulated Microgravity Alters Gene Regulation Linked to Immunity and Cardiovascular Disease. Genes (Basel). 2024 Jul 24; 15(8). Tahimic CGT, Steczina S, Sebastian A, Hum NR, Abegaz M, Terada M, Cimini M, Goukassian DA, Schreurs AS, Hoban-Higgins TM, Fuller CA, Loots GG, Globus RK, Shirazi-Fard Y. PMID: 39202335; PMCID: PMC11353732.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. Host tracheal and intestinal microbiomes inhibit Coccidioides growth in vitro. Microbiol Spectr. 2024 Jul 02; 12(7):e0297823. Tejeda-Garibay S, Zhao L, Hum NR, Pimentel M, Diep AL, Amiri B, Sindi SS, Weilhammer DR, Loots GG, Hoyer KK. PMID: 38832766; PMCID: PMC11218535.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Growth hormone-receptor disruption in mice reduces osteoarthritis and chondrocyte hypertrophy. Geroscience. 2024 Oct; 46(5):4895-4908. Liu H, Davis T, Duran-Ortiz S, Martino T, Erdely A, Profio S, Osipov B, Loots GG, Berryman DE, O'Connor PM, Kopchick JJ, Zhu S. PMID: 38831184; PMCID: PMC11336010.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    5. The application of synthetic antibacterial minerals to combat topical infections: exploring a mouse model of MRSA infection. Sci Rep. 2024 01 19; 14(1):1762. Morrison KD, Reiss MB, Tanner TD, Gollott TR, Loots GG, Collette NM. PMID: 38243067; PMCID: PMC10798972.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. Mef2c regulates bone mass through Sost-dependent and -independent mechanisms. Bone. 2024 02; 179:116976. Morfin C, Sebastian A, Wilson SP, Amiri B, Murugesh DK, Hum NR, Christiansen BA, Loots GG. PMID: 38042445.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    7. Loss of Cadherin-11 in pancreatic ductal adenocarcinoma alters tumor-immune microenvironment. Front Oncol. 2023; 13:1286861. Sebastian A, Martin KA, Peran I, Hum NR, Leon NF, Amiri B, Wilson SP, Coleman MA, Wheeler EK, Byers SW, Loots GG. PMID: 37954069; PMCID: PMC10639148.
      View in: PubMed   Mentions: 1  
    8. Host tracheal and intestinal microbiomes inhibit Coccidioides growth in vitro. bioRxiv. 2023 Oct 23. Tejeda-Garibay S, Zhao L, Hum NR, Pimentel M, Diep AL, Amiri B, Sindi SS, Weilhammer DR, Loots GG, Hoyer KK. PMID: 37961490; PMCID: PMC10634762.
      View in: PubMed   Mentions:
    9. Coccidioidomycosis Osteoarticular Dissemination. J Fungi (Basel). 2023 Oct 11; 9(10). Moni BM, Wise BL, Loots GG, Weilhammer DR. PMID: 37888258; PMCID: PMC10607509.
      View in: PubMed   Mentions:
    10. Engineered bone marrow as a clinically relevant ex vivo model for primary bone cancer research and drug screening. Proc Natl Acad Sci U S A. 2023 09 26; 120(39):e2302101120. Griffin KH, Thorpe SW, Sebastian A, Hum NR, Coonan TP, Sagheb IS, Loots GG, Randall RL, Leach JK. PMID: 37729195; PMCID: PMC10523456.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    11. The dynamic microenvironment associated with metastatic bone disease: Current concepts. J Surg Oncol. 2023 Sep; 128(3):468-477. Bhale R, Ghosh P, Theriault R, Thorpe S, Loots G, Randall RL. PMID: 37226887.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Antibiotic Treatment Prior to Injury Abrogates the Detrimental Effects of LPS in STR/ort Mice Susceptible to Osteoarthritis Development. JBMR Plus. 2023 Aug; 7(8):e10759. Mendez ME, Murugesh DK, Christiansen BA, Loots GG. PMID: 37614305; PMCID: PMC10443070.
      View in: PubMed   Mentions: 1  
    13. Sostdc1 Suppression in the Absence of Sclerostin Potentiates Anabolic Action of Cortical Bone in Mice. J Bone Miner Res. 2023 05; 38(5):765-774. Choi RB, Hoggatt AM, Horan DJ, Rogers EZ, Loots GG, Robling AG. PMID: 36891756; PMCID: PMC10830127.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    14. Degradation-Resistant Hypoxia Inducible Factor-2α in Murine Osteocytes Promotes a High Bone Mass Phenotype. JBMR Plus. 2023 Apr; 7(4):e10724. Mendoza SV, Murugesh DK, Christiansen BA, Genetos ZO, Loots GG, Genetos DC, Yellowley CE. PMID: 37065633; PMCID: PMC10097640.
      View in: PubMed   Mentions: 1  
    15. Isolation of Murine Articular Chondrocytes for Single-Cell RNA or Bulk RNA Sequencing Analysis. Methods Mol Biol. 2023; 2598:187-196. McCool JL, Hum NR, Sebastian A, Loots GG. PMID: 36355293.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    16. Differential bone adaptation to mechanical unloading and reloading in young, old, and osteocyte deficient mice. Bone. 2023 02; 167:116646. Cunningham HC, Orr S, Murugesh DK, Hsia AW, Osipov B, Go L, Wu PH, Wong A, Loots GG, Kazakia GJ, Christiansen BA. PMID: 36529445; PMCID: PMC10077944.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    17. Modulation of Radiation Biomarkers in a Randomized Phase II Study of 131I-MIBG With or Without Radiation Sensitizers for Relapsed or Refractory Neuroblastoma. Int J Radiat Oncol Biol Phys. 2023 04 01; 115(5):1115-1128. Campbell K, Groshen S, Evans AC, Wilson S, Sebastian A, Loots GG, Marachelian A, Armant M, Pal S, Haas-Kogan DA, Park JR, Granger M, Matthay KK, Coleman MA, DuBois SG. PMID: 36526235.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    18. Dose-dependent consequences of sub-chronic fentanyl exposure on neuron and glial co-cultures. Front Toxicol. 2022; 4:983415. Lam D, Sebastian A, Bogguri C, Hum NR, Ladd A, Cadena J, Valdez CA, Fischer NO, Loots GG, Enright HA. PMID: 36032789; PMCID: PMC9403314.
      View in: PubMed   Mentions: 3  
    19. Single-cell RNA-Seq reveals changes in immune landscape in post-traumatic osteoarthritis. Front Immunol. 2022; 13:938075. Sebastian A, Hum NR, McCool JL, Wilson SP, Murugesh DK, Martin KA, Rios-Arce ND, Amiri B, Christiansen BA, Loots GG. PMID: 35967299; PMCID: PMC9373730.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    20. IL-17A Increases Doxorubicin Efficacy in Triple Negative Breast Cancer. Front Oncol. 2022; 12:928474. Hum NR, Sebastian A, Martin KA, Rios-Arce ND, Gilmore SF, Gravano DM, Wheeler EK, Coleman MA, Loots GG. PMID: 35924165; PMCID: PMC9340269.
      View in: PubMed   Mentions:
    21. MAVS mediates a protective immune response in the brain to Rift Valley fever virus. PLoS Pathog. 2022 05; 18(5):e1010231. Hum NR, Bourguet FA, Sebastian A, Lam D, Phillips AM, Sanchez KR, Rasley A, Loots GG, Weilhammer DR. PMID: 35584192; PMCID: PMC9154093.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    22. Interactions Between Diabetes Mellitus and Osteoarthritis: From Animal Studies to Clinical Data. JBMR Plus. 2022 May; 6(5):e10626. Rios-Arce ND, Hum NR, Loots GG. PMID: 35509632; PMCID: PMC9059469.
      View in: PubMed   Mentions: 7  
    23. Preexisting Type 1 Diabetes Mellitus Blunts the Development of Posttraumatic Osteoarthritis. JBMR Plus. 2022 May; 6(5):e10625. Rios-Arce ND, Murugesh DK, Hum NR, Sebastian A, Jbeily EH, Christiansen BA, Loots GG. PMID: 35509635; PMCID: PMC9059474.
      View in: PubMed   Mentions: 6  
    24. Synthetic antibacterial minerals: harnessing a natural geochemical reaction to combat antibiotic resistance. Sci Rep. 2022 01 24; 12(1):1218. Morrison KD, Martin KA, Wimpenny JB, Loots GG. PMID: 35075234; PMCID: PMC8786894.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    25. Extracellular matrix modulates T cell clearance of malignant cells in vitro. Biomaterials. 2022 03; 282:121378. Robertson C, Sebastian A, Hinckley A, Rios-Arce ND, Hynes WF, Edwards SA, He W, Hum NR, Wheeler EK, Loots GG, Coleman MA, Moya ML. PMID: 35121359.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    26. Post-traumatic osteoarthritis progression is diminished by early mechanical unloading and anti-inflammatory treatment in mice. Osteoarthritis Cartilage. 2021 12; 29(12):1709-1719. Hsia AW, Jbeily EH, Mendez ME, Cunningham HC, Biris KK, Bang H, Lee CA, Loots GG, Christiansen BA. PMID: 34653605; PMCID: PMC8678362.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    27. Sclerostin Depletion Induces Inflammation in the Bone Marrow of Mice. Int J Mol Sci. 2021 Aug 24; 22(17). Donham C, Chicana B, Robling AG, Mohamed A, Elizaldi S, Chi M, Freeman B, Millan A, Murugesh DK, Hum NR, Sebastian A, Loots GG, Manilay JO. PMID: 34502021; PMCID: PMC8431516.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    28. Altered canalicular remodeling associated with femur fracture in mice. J Orthop Res. 2022 04; 40(4):891-900. Emami AJ, Sebastian A, Lin YY, Yee CS, Osipov B, Loots GG, Alliston T, Christiansen BA. PMID: 34129247; PMCID: PMC8671555.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    29. Single-Cell RNA-Seq Reveals Transcriptomic Heterogeneity and Post-Traumatic Osteoarthritis-Associated Early Molecular Changes in Mouse Articular Chondrocytes. Cells. 2021 06 10; 10(6). Sebastian A, McCool JL, Hum NR, Murugesh DK, Wilson SP, Christiansen BA, Loots GG. PMID: 34200880; PMCID: PMC8230441.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    30. Improving Bone Health by Optimizing the Anabolic Action of Wnt Inhibitor Multitargeting. JBMR Plus. 2021 May; 5(5):e10462. Choi RB, Bullock WA, Hoggatt AM, Loots GG, Genetos DC, Robling AG. PMID: 33977198; PMCID: PMC8101614.
      View in: PubMed   Mentions: 6  
    31. Cadherin 11 Promotes Immunosuppression and Extracellular Matrix Deposition to Support Growth of Pancreatic Tumors and Resistance to Gemcitabine in Mice. Gastroenterology. 2021 03; 160(4):1359-1372.e13. Peran I, Dakshanamurthy S, McCoy MD, Mavropoulos A, Allo B, Sebastian A, Hum NR, Sprague SC, Martin KA, Pishvaian MJ, Vietsch EE, Wellstein A, Atkins MB, Weiner LM, Quong AA, Loots GG, Yoo SS, Assefnia S, Byers SW. PMID: 33307028; PMCID: PMC7956114.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    32. Antibiotic Treatment Prior to Injury Improves Post-Traumatic Osteoarthritis Outcomes in Mice. Int J Mol Sci. 2020 Sep 03; 21(17). Mendez ME, Murugesh DK, Sebastian A, Hum NR, McCloy SA, Kuhn EA, Christiansen BA, Loots GG. PMID: 32899361; PMCID: PMC7503363.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    33. LPS-Induced Inflammation Prior to Injury Exacerbates the Development of Post-Traumatic Osteoarthritis in Mice. J Bone Miner Res. 2020 11; 35(11):2229-2241. Mendez ME, Sebastian A, Murugesh DK, Hum NR, McCool JL, Hsia AW, Christiansen BA, Loots GG. PMID: 32564401; PMCID: PMC7689775.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    34. Functional and transcriptional characterization of complex neuronal co-cultures. Sci Rep. 2020 07 03; 10(1):11007. Enright HA, Lam D, Sebastian A, Sales AP, Cadena J, Hum NR, Osburn JJ, Peters SKG, Petkus B, Soscia DA, Kulp KS, Loots GG, Wheeler EK, Fischer NO. PMID: 32620908; PMCID: PMC7335084.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    35. Electric Fields at Breast Cancer and Cancer Cell Collective Galvanotaxis. Sci Rep. 2020 05 26; 10(1):8712. Zhu K, Hum NR, Reid B, Sun Q, Loots GG, Zhao M. PMID: 32457381; PMCID: PMC7250931.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    36. Single-Cell Transcriptomic Analysis of Tumor-Derived Fibroblasts and Normal Tissue-Resident Fibroblasts Reveals Fibroblast Heterogeneity in Breast Cancer. Cancers (Basel). 2020 May 21; 12(5). Sebastian A, Hum NR, Martin KA, Gilmore SF, Peran I, Byers SW, Wheeler EK, Coleman MA, Loots GG. PMID: 32455670; PMCID: PMC7281266.
      View in: PubMed   Mentions: 112  
    37. Comparative Molecular Analysis of Cancer Behavior Cultured In Vitro, In Vivo, and Ex Vivo. Cancers (Basel). 2020 Mar 14; 12(3). Hum NR, Sebastian A, Gilmore SF, He W, Martin KA, Hinckley A, Dubbin KR, Moya ML, Wheeler EK, Coleman MA, Loots GG. PMID: 32183351; PMCID: PMC7140030.
      View in: PubMed   Mentions: 10  
    38. Manipulation of the Gut Microbiome Alters Acetaminophen Biodisposition in Mice. Sci Rep. 2020 03 12; 10(1):4571. Malfatti MA, Kuhn EA, Murugesh DK, Mendez ME, Hum N, Thissen JB, Jaing CJ, Loots GG. PMID: 32165665; PMCID: PMC7067795.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    39. Osteogenic preconditioning in perfusion bioreactors improves vascularization and bone formation by human bone marrow aspirates. Sci Adv. 2020 02; 6(7):eaay2387. Harvestine JN, Gonzalez-Fernandez T, Sebastian A, Hum NR, Genetos DC, Loots GG, Leach JK. PMID: 32095526; PMCID: PMC7015678.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    40. Global Gene Expression Analysis Identifies Age-Related Differences in Knee Joint Transcriptome during the Development of Post-Traumatic Osteoarthritis in Mice. Int J Mol Sci. 2020 Jan 06; 21(1). Sebastian A, Murugesh DK, Mendez ME, Hum NR, Rios-Arce ND, McCool JL, Christiansen BA, Loots GG. PMID: 31935848; PMCID: PMC6982134.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    41. Methionine Adenosyltransferase 1a (MAT1A) Enhances Cell Survival During Chemotherapy Treatment and is Associated with Drug Resistance in Bladder Cancer PDX Mice. Int J Mol Sci. 2019 Oct 09; 20(20). Martin KA, Hum NR, Sebastian A, He W, Siddiqui S, Ghosh PM, Pan CX, de Vere White R, Loots GG. PMID: 31600961; PMCID: PMC6829260.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    42. Lrp4 Mediates Bone Homeostasis and Mechanotransduction through Interaction with Sclerostin In Vivo. iScience. 2019 Oct 25; 20:205-215. Bullock WA, Hoggatt AM, Horan DJ, Elmendorf AJ, Sato AY, Bellido T, Loots GG, Pavalko FM, Robling AG. PMID: 31585407; PMCID: PMC6817631.
      View in: PubMed   Mentions: 17  
    43. Expression of a Degradation-Resistant β-Catenin Mutant in Osteocytes Protects the Skeleton From Mechanodeprivation-Induced Bone Wasting. J Bone Miner Res. 2019 10; 34(10):1964-1975. Bullock WA, Hoggatt AM, Horan DJ, Lewis KJ, Yokota H, Hann S, Warman ML, Sebastian A, Loots GG, Pavalko FM, Robling AG. PMID: 31173667; PMCID: PMC6813861.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    44. The Sustained Induction of c-MYC Drives Nab-Paclitaxel Resistance in Primary Pancreatic Ductal Carcinoma Cells. Mol Cancer Res. 2019 09; 17(9):1815-1827. Parasido E, Avetian GS, Naeem A, Graham G, Pishvaian M, Glasgow E, Mudambi S, Lee Y, Ihemelandu C, Choudhry M, Peran I, Banerjee PP, Avantaggiati ML, Bryant K, Baldelli E, Pierobon M, Liotta L, Petricoin E, Fricke ST, Sebastian A, Cozzitorto J, Loots GG, Kumar D, Byers S, Londin E, DiFeo A, Narla G, Winter J, Brody JR, Rodriguez O, Albanese C. PMID: 31164413; PMCID: PMC6726538.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    45. Radiocarbon Tracers in Toxicology and Medicine: Recent Advances in Technology and Science. Toxics. 2019 May 09; 7(2). Malfatti MA, Buchholz BA, Enright HA, Stewart BJ, Ognibene TJ, McCartt AD, Loots GG, Zimmermann M, Scharadin TM, Cimino GD, Jonas BA, Pan CX, Bench G, Henderson PT, Turteltaub KW. PMID: 31075884; PMCID: PMC6631948.
      View in: PubMed   Mentions: 3  
    46. Sostdc1 Regulates NK Cell Maturation and Cytotoxicity. J Immunol. 2019 04 15; 202(8):2296-2306. Millan AJ, Elizaldi SR, Lee EM, Aceves JO, Murugesh D, Loots GG, Manilay JO. PMID: 30814306.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    47. Regional Control of Hairless versus Hair-Bearing Skin by Dkk2. Cell Rep. 2018 12 11; 25(11):2981-2991.e3. Song Y, Boncompagni AC, Kim SS, Gochnauer HR, Zhang Y, Loots GG, Wu D, Li Y, Xu M, Millar SE. PMID: 30509557; PMCID: PMC6345517.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    48. Tracking Tumor Colonization in Xenograft Mouse Models Using Accelerator Mass Spectrometry. Sci Rep. 2018 10 09; 8(1):15013. Hum NR, Martin KA, Malfatti MA, Haack K, Buchholz BA, Loots GG. PMID: 30302019; PMCID: PMC6178347.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    49. Comparative Transcriptomics Identifies Novel Genes and Pathways Involved in Post-Traumatic Osteoarthritis Development and Progression. Int J Mol Sci. 2018 Sep 07; 19(9). Sebastian A, Chang JC, Mendez ME, Murugesh DK, Hatsell S, Economides AN, Christiansen BA, Loots GG. PMID: 30205482; PMCID: PMC6163882.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    50. Vhl deficiency in osteocytes produces high bone mass and hematopoietic defects. Bone. 2018 11; 116:307-314. Loots GG, Robling AG, Chang JC, Murugesh DK, Bajwa J, Carlisle C, Manilay JO, Wong A, Yellowley CE, Genetos DC. PMID: 30172741.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    51. Global gene expression analysis identifies Mef2c as a potential player in Wnt16-mediated transcriptional regulation. Gene. 2018 Oct 30; 675:312-321. Sebastian A, Hum NR, Morfin C, Murugesh DK, Loots GG. PMID: 29981832.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    52. Conditional Deletion of Sost in MSC-Derived Lineages Identifies Specific Cell-Type Contributions to Bone Mass and B-Cell Development. J Bone Miner Res. 2018 10; 33(10):1748-1759. Yee CS, Manilay JO, Chang JC, Hum NR, Murugesh DK, Bajwa J, Mendez ME, Economides AE, Horan DJ, Robling AG, Loots GG. PMID: 29750826.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    53. Sclerostin neutralization unleashes the osteoanabolic effects of Dkk1 inhibition. JCI Insight. 2018 06 07; 3(11). Witcher PC, Miner SE, Horan DJ, Bullock WA, Lim KE, Kang KS, Adaniya AL, Ross RD, Loots GG, Robling AG. PMID: 29875318; PMCID: PMC6124404.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    54. Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer's Patches. Front Immunol. 2018; 9:714. Georgiev H, Ravens I, Papadogianni G, Halle S, Malissen B, Loots GG, Förster R, Bernhardt G. PMID: 29686684; PMCID: PMC5900012.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    55. SOST/Sclerostin Improves Posttraumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury. J Bone Miner Res. 2018 06; 33(6):1105-1113. Chang JC, Christiansen BA, Murugesh DK, Sebastian A, Hum NR, Collette NM, Hatsell S, Economides AN, Blanchette CD, Loots GG. PMID: 29377313; PMCID: PMC6033030.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    56. Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts. PLoS One. 2017; 12(11):e0188264. Sebastian A, Hum NR, Murugesh DK, Hatsell S, Economides AN, Loots GG. PMID: 29176883; PMCID: PMC5703471.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    57. Genetics of Sost/SOST in sclerosteosis and van Buchem disease animal models. Metabolism. 2018 03; 80:38-47. Sebastian A, Loots GG. PMID: 29080811.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    58. Maternal exposure to an environmentally relevant dose of triclocarban results in perinatal exposure and potential alterations in offspring development in the mouse model. PLoS One. 2017; 12(8):e0181996. Enright HA, Falso MJS, Malfatti MA, Lao V, Kuhn EA, Hum N, Shi Y, Sales AP, Haack KW, Kulp KS, Buchholz BA, Loots GG, Bench G, Turteltaub KW. PMID: 28792966; PMCID: PMC5549899.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsPHPublic Health
    59. Wnt Signaling Pathway Inhibitor Sclerostin Inhibits Angiotensin II-Induced Aortic Aneurysm and Atherosclerosis. Arterioscler Thromb Vasc Biol. 2017 Mar; 37(3):553-566. Krishna SM, Seto SW, Jose RJ, Li J, Morton SK, Biros E, Wang Y, Nsengiyumva V, Lindeman JH, Loots GG, Rush CM, Craig JM, Golledge J. PMID: 28062506.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    60. Transcriptional control of Sost in bone. Bone. 2017 03; 96:76-84. Sebastian A, Loots GG. PMID: 27771382.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    61. Sost, independent of the non-coding enhancer ECR5, is required for bone mechanoadaptation. Bone. 2016 11; 92:180-188. Robling AG, Kang KS, Bullock WA, Foster WH, Murugesh D, Loots GG, Genetos DC. PMID: 27601226; PMCID: PMC6673653.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    62. Global molecular changes in a tibial compression induced ACL rupture model of post-traumatic osteoarthritis. J Orthop Res. 2017 03; 35(3):474-485. Chang JC, Sebastian A, Murugesh DK, Hatsell S, Economides AN, Christiansen BA, Loots GG. PMID: 27088242; PMCID: PMC5363336.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    63. Sostdc1 deficiency accelerates fracture healing by promoting the expansion of periosteal mesenchymal stem cells. Bone. 2016 07; 88:20-30. Collette NM, Yee CS, Hum NR, Murugesh DK, Christiansen BA, Xie L, Economides AN, Manilay JO, Robling AG, Loots GG. PMID: 27102547; PMCID: PMC6277141.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    64. SOST Inhibits Prostate Cancer Invasion. PLoS One. 2015; 10(11):e0142058. Hudson BD, Hum NR, Thomas CB, Kohlgruber A, Sebastian A, Collette NM, Coleman MA, Christiansen BA, Loots GG. PMID: 26545120; PMCID: PMC4636315.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    65. Cancer-Osteoblast Interaction Reduces Sost Expression in Osteoblasts and Up-Regulates lncRNA MALAT1 in Prostate Cancer. Microarrays (Basel). 2015 Oct 29; 4(4):503-19. Sebastian A, Hum NR, Hudson BD, Loots GG. PMID: 27600237; PMCID: PMC4996404.
      View in: PubMed   Mentions: 22  
    66. Parathyroid hormone regulation of hypoxia-inducible factor signaling in osteoblastic cells. Bone. 2015 Dec; 81:97-103. Wong A, Loots GG, Yellowley CE, Dosé AC, Genetos DC. PMID: 26151122; PMCID: PMC4641015.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    67. 1α,25-dihydroxyvitamin D3 stimulates human SOST gene expression and sclerostin secretion. Mol Cell Endocrinol. 2015 Sep 15; 413:157-67. Wijenayaka AR, Yang D, Prideaux M, Ito N, Kogawa M, Anderson PH, Morris HA, Solomon LB, Loots GG, Findlay DM, Atkins GJ. PMID: 26112182.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    68. Sclerostin antibody treatment improves fracture outcomes in a Type I diabetic mouse model. Bone. 2016 Jan; 82:122-34. Yee CS, Xie L, Hatsell S, Hum N, Murugesh D, Economides AN, Loots GG, Collette NM. PMID: 25952969; PMCID: PMC4635060.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    69. Nanocomposite scaffold for chondrocyte growth and cartilage tissue engineering: effects of carbon nanotube surface functionalization. Tissue Eng Part A. 2014 Sep; 20(17-18):2305-15. Chahine NO, Collette NM, Thomas CB, Genetos DC, Loots GG. PMID: 24593020; PMCID: PMC4172384.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    70. Evaluation of nanolipoprotein particles (NLPs) as an in vivo delivery platform. PLoS One. 2014; 9(3):e93342. Fischer NO, Weilhammer DR, Dunkle A, Thomas C, Hwang M, Corzett M, Lychak C, Mayer W, Urbin S, Collette N, Chiun Chang J, Loots GG, Rasley A, Blanchette CD. PMID: 24675794; PMCID: PMC3968139.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    71. The use of nanolipoprotein particles to enhance the immunostimulatory properties of innate immune agonists against lethal influenza challenge. Biomaterials. 2013 Dec; 34(38):10305-18. Weilhammer DR, Blanchette CD, Fischer NO, Alam S, Loots GG, Corzett M, Thomas C, Lychak C, Dunkle AD, Ruitenberg JJ, Ghanekar SA, Sant AJ, Rasley A. PMID: 24075406; PMCID: PMC7172747.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    72. How genomics is changing our view of cancer. Brief Funct Genomics. 2013 Sep; 12(5):389-90. Loots GG. PMID: 24048221.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    73. Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner. Dev Biol. 2013 Nov 01; 383(1):90-105. Collette NM, Yee CS, Murugesh D, Sebastian A, Taher L, Gale NW, Economides AN, Harland RM, Loots GG. PMID: 23994639; PMCID: PMC3861057.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    74. Prostate cancer invasion and metastasis: insights from mining genomic data. Brief Funct Genomics. 2013 Sep; 12(5):397-410. Hudson BD, Kulp KS, Loots GG. PMID: 23878130.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    75. Interrogating transcriptional regulatory sequences in Tol2-mediated Xenopus transgenics. PLoS One. 2013; 8(7):e68548. Loots GG, Bergmann A, Hum NR, Oldenburg CE, Wills AE, Hu N, Ovcharenko I, Harland RM. PMID: 23874664; PMCID: PMC3713029.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    76. Effect of age and cytoskeletal elements on the indentation-dependent mechanical properties of chondrocytes. PLoS One. 2013; 8(4):e61651. Chahine NO, Blanchette C, Thomas CB, Lu J, Haudenschild D, Loots GG. PMID: 23613892; PMCID: PMC3628340.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    77. Targeted deletion of Sost distal enhancer increases bone formation and bone mass. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14092-7. Collette NM, Genetos DC, Economides AN, Xie L, Shahnazari M, Yao W, Lane NE, Harland RM, Loots GG. PMID: 22886088; PMCID: PMC3435175.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    78. Absence of sclerostin adversely affects B-cell survival. J Bone Miner Res. 2012 Jul; 27(7):1451-61. Cain CJ, Rueda R, McLelland B, Collette NM, Loots GG, Manilay JO. PMID: 22434688; PMCID: PMC3377789.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    79. Long-term administration of AMD3100, an antagonist of SDF-1/CXCR4 signaling, alters fracture repair. J Orthop Res. 2012 Nov; 30(11):1853-9. Toupadakis CA, Wong A, Genetos DC, Chung DJ, Murugesh D, Anderson MJ, Loots GG, Christiansen BA, Kapatkin AS, Yellowley CE. PMID: 22592891; PMCID: PMC3704138.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    80. Global gene expression analysis of murine limb development. PLoS One. 2011; 6(12):e28358. Taher L, Collette NM, Murugesh D, Maxwell E, Ovcharenko I, Loots GG. PMID: 22174793; PMCID: PMC3235105.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    81. TGF-β regulates sclerostin expression via the ECR5 enhancer. Bone. 2012 Mar; 50(3):663-9. Loots GG, Keller H, Leupin O, Murugesh D, Collette NM, Genetos DC. PMID: 22155511; PMCID: PMC3278543.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    82. Prostaglandin E2 signals through PTGER2 to regulate sclerostin expression. PLoS One. 2011 Mar 16; 6(3):e17772. Genetos DC, Yellowley CE, Loots GG. PMID: 21436889; PMCID: PMC3059227.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    83. Hypoxia decreases sclerostin expression and increases Wnt signaling in osteoblasts. J Cell Biochem. 2010 May 15; 110(2):457-67. Genetos DC, Toupadakis CA, Raheja LF, Wong A, Papanicolaou SE, Fyhrie DP, Loots GG, Yellowley CE. PMID: 20336693; PMCID: PMC2881162.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    84. Genetic evidence that SOST inhibits WNT signaling in the limb. Dev Biol. 2010 Jun 15; 342(2):169-79. Collette NM, Genetos DC, Murugesh D, Harland RM, Loots GG. PMID: 20359476; PMCID: PMC2896299.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    85. Parathyroid hormone (PTH)-induced bone gain is blunted in SOST overexpressing and deficient mice. J Bone Miner Res. 2010 Feb; 25(2):178-89. Kramer I, Loots GG, Studer A, Keller H, Kneissel M. PMID: 19594304; PMCID: PMC3153379.
      View in: PubMed   Mentions: 107     Fields:    Translation:Animals
    86. Human variation in short regions predisposed to deep evolutionary conservation. Mol Biol Evol. 2010 Jun; 27(6):1279-88. Loots GG, Ovcharenko I. PMID: 20093432; PMCID: PMC2872621.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    87. Genomic identification of regulatory elements by evolutionary sequence comparison and functional analysis. Adv Genet. 2008; 61:269-93. Loots GG. PMID: 18282510; PMCID: PMC2882178.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    88. Control of the SOST bone enhancer by PTH using MEF2 transcription factors. J Bone Miner Res. 2007 Dec; 22(12):1957-67. Leupin O, Kramer I, Collette NM, Loots GG, Natt F, Kneissel M, Keller H. PMID: 17696759; PMCID: PMC2882185.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
    89. Predicting tissue-specific enhancers in the human genome. Genome Res. 2007 Feb; 17(2):201-11. Pennacchio LA, Loots GG, Nobrega MA, Ovcharenko I. PMID: 17210927; PMCID: PMC1781352.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    90. Mulan: multiple-sequence alignment to predict functional elements in genomic sequences. Methods Mol Biol. 2007; 395:237-54. Loots GG, Ovcharenko I. PMID: 17993678; PMCID: PMC3704129.
      View in: PubMed   Mentions: 10     Fields:    
    91. ECRbase: database of evolutionary conserved regions, promoters, and transcription factor binding sites in vertebrate genomes. Bioinformatics. 2007 Jan 01; 23(1):122-4. Loots G, Ovcharenko I. PMID: 17090579.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    92. Array2BIO: from microarray expression data to functional annotation of co-regulated genes. BMC Bioinformatics. 2006 Jun 16; 7:307. Loots GG, Chain PS, Mabery S, Rasley A, Garcia E, Ovcharenko I. PMID: 16780584; PMCID: PMC1513257.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    93. Modifying yeast artificial chromosomes to generate Cre/LoxP and FLP/FRT site-specific deletions and inversions. Methods Mol Biol. 2006; 349:75-84. Loots GG. PMID: 17071975.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    94. Dcode.org anthology of comparative genomic tools. Nucleic Acids Res. 2005 Jul 01; 33(Web Server issue):W56-64. Loots GG, Ovcharenko I. PMID: 15980535; PMCID: PMC1160116.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    95. Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease. Genome Res. 2005 Jul; 15(7):928-35. Loots GG, Kneissel M, Keller H, Baptist M, Chang J, Collette NM, Ovcharenko D, Plajzer-Frick I, Rubin EM. PMID: 15965026; PMCID: PMC1172036.
      View in: PubMed   Mentions: 185     Fields:    Translation:HumansAnimalsCells
    96. Strategies for characterising cis-regulatory elements in Xenopus. Brief Funct Genomic Proteomic. 2005 May; 4(1):58-68. Khokha MK, Loots GG. PMID: 15975265.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    97. Mulan: multiple-sequence local alignment and visualization for studying function and evolution. Genome Res. 2005 Jan; 15(1):184-94. Ovcharenko I, Loots GG, Giardine BM, Hou M, Ma J, Hardison RC, Stubbs L, Miller W. PMID: 15590941; PMCID: PMC540288.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    98. Evolution and functional classification of vertebrate gene deserts. Genome Res. 2005 Jan; 15(1):137-45. Ovcharenko I, Loots GG, Nobrega MA, Hardison RC, Miller W, Stubbs L. PMID: 15590943; PMCID: PMC540279.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansAnimalsCells
    99. Interpreting mammalian evolution using Fugu genome comparisons. Genomics. 2004 Nov; 84(5):890-5. Ovcharenko I, Stubbs L, Loots GG. PMID: 15475268.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    100. CREME: Cis-Regulatory Module Explorer for the human genome. Nucleic Acids Res. 2004 Jul 01; 32(Web Server issue):W253-6. Sharan R, Ben-Hur A, Loots GG, Ovcharenko I. PMID: 15215390; PMCID: PMC441523.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    101. rVISTA 2.0: evolutionary analysis of transcription factor binding sites. Nucleic Acids Res. 2004 Jul 01; 32(Web Server issue):W217-21. Loots GG, Ovcharenko I. PMID: 15215384; PMCID: PMC441521.
      View in: PubMed   Mentions: 222     Fields:    Translation:Cells
    102. ECR Browser: a tool for visualizing and accessing data from comparisons of multiple vertebrate genomes. Nucleic Acids Res. 2004 Jul 01; 32(Web Server issue):W280-6. Ovcharenko I, Nobrega MA, Loots GG, Stubbs L. PMID: 15215395; PMCID: PMC441493.
      View in: PubMed   Mentions: 272     Fields:    Translation:HumansAnimalsCells
    103. eShadow: a tool for comparing closely related sequences. Genome Res. 2004 Jun; 14(6):1191-8. Ovcharenko I, Boffelli D, Loots GG. PMID: 15173121; PMCID: PMC419798.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    104. zPicture: dynamic alignment and visualization tool for analyzing conservation profiles. Genome Res. 2004 Mar; 14(3):472-7. Ovcharenko I, Loots GG, Hardison RC, Miller W, Stubbs L. PMID: 14993211; PMCID: PMC353235.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    105. Comparative genomic tools for exploring the human genome. Cold Spring Harb Symp Quant Biol. 2003; 68:283-91. Ovcharenko I, Loots GG. PMID: 15338628.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    106. SNPs in putative regulatory regions identified by human mouse comparative sequencing and transcription factor binding site data. Mamm Genome. 2002 Oct; 13(10):554-7. Banerjee P, Bahlo M, Schwartz JR, Loots GG, Houston KA, Dubchak I, Speed TP, Rubin EM. PMID: 12420132.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    107. rVista for comparative sequence-based discovery of functional transcription factor binding sites. Genome Res. 2002 May; 12(5):832-9. Loots GG, Ovcharenko I, Pachter L, Dubchak I, Rubin EM. PMID: 11997350; PMCID: PMC186580.
      View in: PubMed   Mentions: 191     Fields:    Translation:HumansAnimalsCells
    108. Deletion of a coordinate regulator of type 2 cytokine expression in mice. Nat Immunol. 2001 Sep; 2(9):842-7. Mohrs M, Blankespoor CM, Wang ZE, Loots GG, Afzal V, Hadeiba H, Shinkai K, Rubin EM, Locksley RM. PMID: 11526400.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    109. Active conservation of noncoding sequences revealed by three-way species comparisons. Genome Res. 2000 Sep; 10(9):1304-6. Dubchak I, Brudno M, Loots GG, Pachter L, Mayor C, Rubin EM, Frazer KA. PMID: 10984448; PMCID: PMC310906.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimalsCells
    110. Database searches for binding sites. Science. 2000 Jun 30; 288(5475):2319a. Murphy K, Frazer KA, Loots G, Rubin EM. PMID: 17769838.
      View in: PubMed   Mentions:    Fields:    
    111. Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons. Science. 2000 Apr 07; 288(5463):136-40. Loots GG, Locksley RM, Blankespoor CM, Wang ZE, Miller W, Rubin EM, Frazer KA. PMID: 10753117.
      View in: PubMed   Mentions: 266     Fields:    Translation:HumansAnimalsCells
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