Joseph G Hacia, PhD

Title(s)Professor of Biochemistry & Molecular Medicine
SchoolKeck School of Medicine of Usc
AddressCSC 240A, 2250 Alcazar Street
Health Sciences Campus
Los Angeles CA 90089
Phone+1 323 442 3030
ORCID ORCID Icon0000-0002-1481-9282 Additional info
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    Other Positions
    Title(s)Vice Chair for Medical Education


    Collapse Biography 
    Collapse Education and Training
    Rutgers University, New Brunswick, NJBS05/1989Biochemistry
    California Institute of Technology, Pasadena, CAPhD02/1995Biology
    National Institutes of Health, Bethesda, MDPost-doc11/2000Genetics/Genomics
    Collapse Awards and Honors
    Howard Hughes Medical Institute1989  - 1995Howard Hughes Medical Institute Predoctoral Fellow
    American Society of Human Genetics2000American Society of Human Genetics (ASHG) Postdoctoral Translational Research Award
    The V Foundation for Cancer Research2002V Foundation Scholar
    Genome Research2004  - 2010Editorial Board of Genome Research
    University of Southern California2008  - 2013Member of NIH Comparative Genomics Study Section
    Nucleic Acids Research2008Editorial Board Nucleic Acids Research
    American Society of Human Genetics2010Chaired Session at ASHG meeting on Early Diagnosis and Treatment of CNS-based Metabolic Disorders
    BMC Genomics2010Editorial Board BMC Genomics
    Global Foundation for Peroxisomal Disorders2010Member, Scientific Advisory Board, Global Foundation for Peroxisomal Disorders
    California Institute for Regenerative Medicine2012External Reviewer, Institute of Medicine Review of California Institute for Regenerative Medicine
    University of Southern California2013Year 1 USC Medical Teaching Award
    American Society of Human Genetics2014Chaired Session at ASHG meeting on Targeted Drug Therapies for Progressive Genetic Disorders
    University of Southern California2015Year 2 USC Medical Teaching Award
    ALD Connect2015Member of X-linked Adrenoleukodystrophy (ALD) Connect Workgroup on Therapy Review
    American Society of Gene and Cell Therapy2015  - 2018Member of Chemical Gene & Cell Therapy Committee of the American Society of Gene & Cell Therapy
    BMC Medical Genomics2016Editorial Board BMC Medical Genomics
    University of Southern California2016Year 1 USC Medical Teaching Award
    University of Southern California2016Year 1 Outstanding Course Award for USC Medical Teaching
    University of Southern California2016Master Teacher of the Keck School of Medicine of USC
    RhizoKids International2016Member, Scientific Advisory Board, RhizoKids International
    Kennedy Krieger Institute2016Chaired Session at ‘Leukodystrophies Conference’ in Baltimore, Maryland
    Global Foundation for Peroxisomal Disorders2017  - 2022Co-organized Global Foundation for Peroxisomal Disorders Scientific Conferences
    Global Foundation for Peroxisomal Disorders2017Award of Recognition for Excellence in Scientific Community Building for PBD Research by the GFPD
    University of Southern California2018Year 1 USC Medical Teaching Award
    United Leukodystrophy Foundation2019Member, Board of Directors, United Leukodystrophy Foundation
    Global DARE Foundation2019  - 2022co-Chair Scientific Advisory Board, Global DARE Foundation
    The Jackson Laboratory2020Adjunct Faculty Member, The Jackson Laboratory, Bar Harbor, Maine
    University of Southern California2021Kaiser-Permanente Excellence in Teaching Award for the Basic Science Years of Medical School
    University of Southern California2022Kaiser-Permanente Excellence in Teaching Award for the Basic Science Years of Medical School
    University of Southern California2022Alpha Omega Alpha (AOA) Medical Honor Society by vote of the Class of 2022, Keck School of Medicine
    Global DARE Foundation2022Chair Scientific Advisory Board, Global DARE Foundation
    American Society of Human Genetics2023Chaired Session at ASHG meeting on Finding NEMO: Novel Enhanced Model Organism/Organs-on-Chips
    University of Southern California2023Kaiser-Permanente Excellence in Teaching Award for the Basic Science Years of Medical School
    University of Southern California2023Dean’s Award for Excellence in Teaching
    University of Southern California2024Kaiser-Permanente Excellence in Teaching Award for the Basic Science Years of Medical School

    Collapse Overview 
    Collapse Overview
    Joe Hacia is a medical geneticist and Professor in the Department of Biochemistry and Molecular Medicine at the Keck School of Medicine of the University of Southern California. The Hacia laboratory focuses on developing therapies for genetic disorders caused by impaired peroxisome assembly, structure, and function. His group focuses on peroxisome biogenesis disorders (PBDs), which include Zellweger spectrum disorder (ZSD) and rhizomelic chondrodysplasia punctata (RCDP), and adult Refsum disease (ARD). Peroxisomal disorders can effect the functions of numerous organ systems and, depending on the subtype and severity, can frequently result in progressive vision and hearing loss, impaired neurological and liver functions, and skeletal and enamel defects.

    The Hacia laboratory is involved in screening small molecule libraries for candidate therapies for peroxisomal disorders as well as gene augmentation and gene editing projects in mouse models of disease. By working closely with physician-scientists and patient advocacy groups including the Global Foundation for Peroxisomal Disorders (GFPD) (https://www.thegfpd.org/), RhizoKids International (https://www.rhizokids.com/), United Leukodystrophy Foundation (https:/ulf.org), and Global DARE Foundation (https://www.defeatadultrefsumeverywhere.org/) they seek to translate their research into improved treatments in the near future.

    The Hacia laboratory has also used comparative genomic and lipidomic approaches to uncover evidence that peroxisomal metabolic activities has been strongly influenced by diet in primate lineages. They wish to use the knowledge gained from these projects to benefit the health of captive non-human primates and people affected by peroxisomal disorders.

    Research Interests: medical genetics, molecular therapies, gene therapies
    Diseases Models: cultured fibroblasts, induced pluripotent stem cells, genome-edited cell lines, genetically engineered rodents
    Consortia: Global Foundation for Peroxisomal Disorders, RhizoKids International, United Leukodystrophy Foundation, Global DARE Foundation, Hannah's Hope Fund
    Collapse Websites

    Collapse Research 
    Collapse Research Activities and Funding
    A Mouse Model Resource for Peroxisome Research
    NIH/OD R24OD030033Apr 15, 2022 - Jan 31, 2026
    Role: Corresponding PI
    Description: The Mouse Peroxisome Research Resource (MPRR) serves as a central resource for mouse models and monoclonal antibodies for basic and translational research in peroxisome biology.
    USC FaceBase III Craniofacial Development and Dysmorpholoy Data Management and Integration Hub
    NIH U01DE028729Aug 1, 2019 - Jul 31, 2024
    Role: Co-Investigator
    CRE MOUSE MODELS TO STUDY AMELOGENESIS
    NIH UG3DE028850Aug 1, 2019 - Jul 31, 2021
    Role: Co-Investigator
    Development of Targeted Therapies for Peroxisome Biogenesis Disorders: Current and future prospects
    NIH R13NS100379Sep 30, 2016 - Aug 31, 2018
    Role: Principal Investigator
    Targeted Therapies for Peroxisome Biogenesis Disorders
    Global Foundation for Peroxisomal Disorders GFPDSep 1, 2013 - Dec 31, 2019
    Role: Principal Investigator
    NINDS Exploratory/Developmental Projects in Translational Research
    NIH R21NS064572Sep 15, 2008 - Aug 31, 2011
    Role: Principal Investigator
    Mutational Analysis of Peroxisome Biogenesis Disorders
    NIH R21HD050277Aug 3, 2005 - Jul 31, 2008
    Role: Principal Investigator
    Comparative Genomics of Peroxisomal Lipid Metabolism
    NIH R01GM072477Apr 1, 2005 - Mar 31, 2011
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Faculty Mentoring
    Collapse Required Scholarly Project Mentor

    Collapse Featured Content 
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. FaceBase: A Community-Driven Hub for Data-Intensive Research. J Dent Res. 2022 10; 101(11):1289-1298. Schuler RE, Bugacov A, Hacia JG, Ho TV, Iwata J, Pearlman L, Samuels BD, Williams C, Zhao Z, Kesselman C, Chai Y. PMID: 35912790; PMCID: PMC9516628.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    2. Clinical diagnosis of metabolic disorders using untargeted metabolomic profiling and disease-specific networks learned from profiling data. Sci Rep. 2022 04 21; 12(1):6556. Thistlethwaite LR, Li X, Burrage LC, Riehle K, Hacia JG, Braverman N, Wangler MF, Miller MJ, Elsea SH, Milosavljevic A. PMID: 35449147; PMCID: PMC9023513.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    3. AAV-mediated PEX1 gene augmentation improves visual function in the PEX1-Gly844Asp mouse model for mild Zellweger spectrum disorder. Mol Ther Methods Clin Dev. 2021 Dec 10; 23:225-240. Argyriou C, Polosa A, Song JY, Omri S, Steele B, Cécyre B, McDougald DS, Di Pietro E, Bouchard JF, Bennett J, Hacia JG, Lachapelle P, Braverman NE. PMID: 34703844; PMCID: PMC8516995.
      View in: PubMed   Mentions: 7  
    4. FaceBase 3: analytical tools and FAIR resources for craniofacial and dental research. Development. 2020 09 21; 147(18). Samuels BD, Aho R, Brinkley JF, Bugacov A, Feingold E, Fisher S, Gonzalez-Reiche AS, Hacia JG, Hallgrimsson B, Hansen K, Harris MP, Ho TV, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Leslie EJ, Li H, Liao EC, Long H, Lu N, Maas RL, Marazita ML, Mohammed J, Prescott S, Schuler R, Selleri L, Spritz RA, Swigut T, van Bakel H, Visel A, Welsh I, Williams C, Williams TJ, Wysocka J, Yuan Y, Chai Y. PMID: 32958507; PMCID: PMC7522026.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    5. Zellweger spectrum disorder patient-derived fibroblasts with the PEX1-Gly843Asp allele recover peroxisome functions in response to flavonoids. J Cell Biochem. 2019 03; 120(3):3243-3258. MacLean GE, Argyriou C, Di Pietro E, Sun X, Birjandian S, Saberian P, Hacia JG, Braverman NE. PMID: 30362618.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    6. X-linked adrenoleukodystrophy in a chimpanzee due to an ABCD1 mutation reported in multiple unrelated humans. Mol Genet Metab. 2017 11; 122(3):130-133. Curiel J, Steinberg SJ, Bright S, Snowden A, Moser AB, Eichler F, Dubbs HA, Hacia JG, Ely JJ, Bezner J, Gean A, Vanderver A. PMID: 28919002.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    7. MiR-153 Regulates Amelogenesis by Targeting Endocytotic and Endosomal/lysosomal Pathways-Novel Insight into the Origins of Enamel Pathologies. Sci Rep. 2017 03 13; 7:44118. Yin K, Lin W, Guo J, Sugiyama T, Snead ML, Hacia JG, Paine ML. PMID: 28287144; PMCID: PMC5347039.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    8. Novel Gene Expression Signature Predictive of Clinical Recurrence After Radical Prostatectomy in Early Stage Prostate Cancer Patients. Prostate. 2016 10; 76(14):1239-56. Shahabi A, Lewinger JP, Ren J, April C, Sherrod AE, Hacia JG, Daneshmand S, Gill I, Pinski JK, Fan JB, Stern MC. PMID: 27272349; PMCID: PMC9015679.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    9. Peroxisome biogenesis disorders in the Zellweger spectrum: An overview of current diagnosis, clinical manifestations, and treatment guidelines. Mol Genet Metab. 2016 Mar; 117(3):313-21. Braverman NE, Raymond GV, Rizzo WB, Moser AB, Wilkinson ME, Stone EM, Steinberg SJ, Wangler MF, Rush ET, Hacia JG, Bose M. PMID: 26750748; PMCID: PMC5214431.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansCells
    10. Derivation of induced pluripotent stem cells from orangutan skin fibroblasts. BMC Res Notes. 2015 Oct 16; 8:577. Ramaswamy K, Yik WY, Wang XM, Oliphant EN, Lu W, Shibata D, Ryder OA, Hacia JG. PMID: 26475477; PMCID: PMC4609060.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    11. Induced pluripotent stem cell models of Zellweger spectrum disorder show impaired peroxisome assembly and cell type-specific lipid abnormalities. Stem Cell Res Ther. 2015 Aug 29; 6:158. Wang XM, Yik WY, Zhang P, Lu W, Huang N, Kim BR, Shibata D, Zitting M, Chow RH, Moser AB, Steinberg SJ, Hacia JG. PMID: 26319495; PMCID: PMC4553005.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    12. Genome-wide analysis of miRNA and mRNA transcriptomes during amelogenesis. BMC Genomics. 2014 Nov 19; 15:998. Yin K, Hacia JG, Zhong Z, Paine ML. PMID: 25406666; PMCID: PMC4254193.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    13. The Pex1-G844D mouse: a model for mild human Zellweger spectrum disorder. Mol Genet Metab. 2014 Apr; 111(4):522-532. Hiebler S, Masuda T, Hacia JG, Moser AB, Faust PL, Liu A, Chowdhury N, Huang N, Lauer A, Bennett J, Watkins PA, Zack DJ, Braverman NE, Raymond GV, Steinberg SJ. PMID: 24503136; PMCID: PMC4901203.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    14. Identification of candidate downstream targets of TGFβ signaling during palate development by genome-wide transcript profiling. J Cell Biochem. 2013 Apr; 114(4):796-807. Pelikan RC, Iwata J, Suzuki A, Chai Y, Hacia JG. PMID: 23060211; PMCID: PMC3777336.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    15. Diverse captive non-human primates with phytanic acid-deficient diets rich in plant products have substantial phytanic acid levels in their red blood cells. Lipids Health Dis. 2013 Feb 04; 12:10. Moser AB, Hey J, Dranchak PK, Karaman MW, Zhao J, Cox LA, Ryder OA, Hacia JG. PMID: 23379307; PMCID: PMC3571895.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    16. The gene expression profiles of induced pluripotent stem cells from individuals with childhood cerebral adrenoleukodystrophy are consistent with proposed mechanisms of pathogenesis. Stem Cell Res Ther. 2012 Oct 04; 3(5):39. Wang XM, Yik WY, Zhang P, Lu W, Dranchak PK, Shibata D, Steinberg SJ, Hacia JG. PMID: 23036268; PMCID: PMC3580430.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    17. A founder mutation in the PEX6 gene is responsible for increased incidence of Zellweger syndrome in a French Canadian population. BMC Med Genet. 2012 Aug 15; 13:72. Levesque S, Morin C, Guay SP, Villeneuve J, Marquis P, Yik WY, Jiralerspong S, Bouchard L, Steinberg S, Hacia JG, Dewar K, Braverman NE. PMID: 22894767; PMCID: PMC3483250.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    18. The circadian clock modulates enamel development. J Biol Rhythms. 2012 Jun; 27(3):237-45. Lacruz RS, Hacia JG, Bromage TG, Boyde A, Lei Y, Xu Y, Miller JD, Paine ML, Snead ML. PMID: 22653892; PMCID: PMC3511783.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    19. Identification of novel candidate genes involved in mineralization of dental enamel by genome-wide transcript profiling. J Cell Physiol. 2012 May; 227(5):2264-75. Lacruz RS, Smith CE, Bringas P, Chen YB, Smith SM, Snead ML, Kurtz I, Hacia JG, Hubbard MJ, Paine ML. PMID: 21809343; PMCID: PMC3243804.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    20. A TGFβ-Smad4-Fgf6 signaling cascade controls myogenic differentiation and myoblast fusion during tongue development. Development. 2012 May; 139(9):1640-50. Han D, Zhao H, Parada C, Hacia JG, Bringas P, Chai Y. PMID: 22438570; PMCID: PMC3317969.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    21. Modulation of noncanonical TGF-β signaling prevents cleft palate in Tgfbr2 mutant mice. J Clin Invest. 2012 Mar; 122(3):873-85. Iwata J, Hacia JG, Suzuki A, Sanchez-Lara PA, Urata M, Chai Y. PMID: 22326956; PMCID: PMC3287237.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    22. Gene-expression analysis of early- and late-maturation-stage rat enamel organ. Eur J Oral Sci. 2011 Dec; 119 Suppl 1:149-57. Lacruz RS, Smith CE, Chen YB, Hubbard MJ, Hacia JG, Paine ML. PMID: 22243241; PMCID: PMC3286129.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    23. Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth factor β (TGFβ) signaling to regulate cell proliferation in palatal mesenchyme during mouse palatogenesis. J Biol Chem. 2012 Jan 20; 287(4):2353-63. Iwata J, Tung L, Urata M, Hacia JG, Pelikan R, Suzuki A, Ramenzoni L, Chaudhry O, Parada C, Sanchez-Lara PA, Chai Y. PMID: 22123828; PMCID: PMC3268397.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    24. [A case of bullous lupus in black skin]. Ann Dermatol Venereol. 2011 Nov; 138(11):792-4. Lorcy S, Hacia J, Roche C, de Biasi C, Lightburne E, Morand JJ. PMID: 22078046.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Human and great ape red blood cells differ in plasmalogen levels and composition. Lipids Health Dis. 2011 Jun 17; 10:101. Moser AB, Steinberg SJ, Watkins PA, Moser HW, Ramaswamy K, Siegmund KD, Lee DR, Ely JJ, Ryder OA, Hacia JG. PMID: 21679470; PMCID: PMC3129581.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    26. Nonsense suppressor therapies rescue peroxisome lipid metabolism and assembly in cells from patients with specific PEX gene mutations. J Cell Biochem. 2011 May; 112(5):1250-8. Dranchak PK, Di Pietro E, Snowden A, Oesch N, Braverman NE, Steinberg SJ, Hacia JG. PMID: 21465523; PMCID: PMC3136445.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    27. Structural analysis of a repetitive protein sequence motif in strepsirrhine primate amelogenin. PLoS One. 2011 Mar 18; 6(3):e18028. Lacruz RS, Lakshminarayanan R, Bromley KM, Hacia JG, Bromage TG, Snead ML, Moradian-Oldak J, Paine ML. PMID: 21437261; PMCID: PMC3060920.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    28. Identification of differences in human and great ape phytanic acid metabolism that could influence gene expression profiles and physiological functions. BMC Physiol. 2010 Oct 08; 10:19. Watkins PA, Moser AB, Toomer CB, Steinberg SJ, Moser HW, Karaman MW, Ramaswamy K, Siegmund KD, Lee DR, Ely JJ, Ryder OA, Hacia JG. PMID: 20932325; PMCID: PMC2964658.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    29. Identification and functional relevance of de novo DNA methylation in cancerous B-cell populations. J Cell Biochem. 2010 Mar 01; 109(4):818-27. Wang XM, Greiner TC, Bibikova M, Pike BL, Siegmund KD, Sinha UK, Müschen M, Jaeger EB, Weisenburger DD, Chan WC, Shibata D, Fan JB, Hacia JG. PMID: 20069569; PMCID: PMC3122883.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    30. Development and evaluation of new mask protocols for gene expression profiling in humans and chimpanzees. BMC Bioinformatics. 2009 Mar 05; 10:77. Toleno DM, Renaud G, Wolfsberg TG, Islam M, Wildman DE, Siegmund KD, Hacia JG. PMID: 19265541; PMCID: PMC2660304.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    31. Identification of novel mutations and sequence variation in the Zellweger syndrome spectrum of peroxisome biogenesis disorders. Hum Mutat. 2009 Mar; 30(3):E467-80. Yik WY, Steinberg SJ, Moser AB, Moser HW, Hacia JG. PMID: 19105186; PMCID: PMC2649967.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    32. mtDNA depletion confers specific gene expression profiles in human cells grown in culture and in xenograft. BMC Genomics. 2008 Nov 03; 9:521. Magda D, Lecane P, Prescott J, Thiemann P, Ma X, Dranchak PK, Toleno DM, Ramaswamy K, Siegmund KD, Hacia JG. PMID: 18980691; PMCID: PMC2612029.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    33. Synthesis and anticancer properties of water-soluble zinc ionophores. Cancer Res. 2008 Jul 01; 68(13):5318-25. Magda D, Lecane P, Wang Z, Hu W, Thiemann P, Ma X, Dranchak PK, Wang X, Lynch V, Wei W, Csokai V, Hacia JG, Sessler JL. PMID: 18593933; PMCID: PMC3033660.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    34. Age-related gene expression profiles of rhesus monkey bone marrow-derived mesenchymal stem cells. J Cell Biochem. 2008 Mar 01; 103(4):1198-210. Hacia JG, Lee CC, Jimenez DF, Karaman MW, Ho VV, Siegmund KD, Tarantal AF. PMID: 17685434.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    35. DNA methylation profiles in diffuse large B-cell lymphoma and their relationship to gene expression status. Leukemia. 2008 May; 22(5):1035-43. Pike BL, Greiner TC, Wang X, Weisenburger DD, Hsu YH, Renaud G, Wolfsberg TG, Kim M, Weisenberger DJ, Siegmund KD, Ye W, Groshen S, Mehrian-Shai R, Delabie J, Chan WC, Laird PW, Hacia JG. PMID: 18288132; PMCID: PMC2654231.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    36. Loss of p53 expression correlates with metastatic phenotype and transcriptional profile in a new mouse model of head and neck cancer. Mol Cancer Res. 2007 Apr; 5(4):351-62. Ku TK, Nguyen DC, Karaman M, Gill P, Hacia JG, Crowe DL. PMID: 17426250.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    37. Synthesis and biologic properties of hydrophilic sapphyrins, a new class of tumor-selective inhibitors of gene expression. Mol Cancer. 2007 Jan 19; 6:9. Wang Z, Lecane PS, Thiemann P, Fan Q, Cortez C, Ma X, Tonev D, Miles D, Naumovski L, Miller RA, Magda D, Cho DG, Sessler JL, Pike BL, Yeligar SM, Karaman MW, Hacia JG. PMID: 17233922; PMCID: PMC1784109.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    38. Comparisons of PCR-based genome amplification systems using CpG island microarrays. Hum Mutat. 2006 Jun; 27(6):589-96. Pike BL, Groshen S, Hsu YH, Shai RM, Wang X, Holtan N, Futscher BW, Hacia JG. PMID: 16652338.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    39. Mutation and genomic deletion status of ataxia telangiectasia mutated (ATM) and p53 confer specific gene expression profiles in mantle cell lymphoma. Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7):2352-7. Greiner TC, Dasgupta C, Ho VV, Weisenburger DD, Smith LM, Lynch JC, Vose JM, Fu K, Armitage JO, Braziel RM, Campo E, Delabie J, Gascoyne RD, Jaffe ES, Muller-Hermelink HK, Ott G, Rosenwald A, Staudt LM, Im MY, Karaman MW, Pike BL, Chan WC, Hacia JG. PMID: 16461462; PMCID: PMC1413716.
      View in: PubMed   Mentions: 63     Fields:    Translation:Humans
    40. Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15; 65(24):11676-88. Lecane PS, Karaman MW, Sirisawad M, Naumovski L, Miller RA, Hacia JG, Magda D. PMID: 16357179.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    41. Motexafin gadolinium disrupts zinc metabolism in human cancer cell lines. Cancer Res. 2005 May 01; 65(9):3837-45. Magda D, Lecane P, Miller RA, Lepp C, Miles D, Mesfin M, Biaglow JE, Ho VV, Chawannakul D, Nagpal S, Karaman MW, Hacia JG. PMID: 15867382.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    42. Leaky ribosomal scanning in mammalian genomes: significance of histone H4 alternative translation in vivo. Nucleic Acids Res. 2005; 33(4):1298-308. Smith E, Meyerrose TE, Kohler T, Namdar-Attar M, Bab N, Lahat O, Noh T, Li J, Karaman MW, Hacia JG, Chen TT, Nolta JA, Müller R, Bab I, Frenkel B. PMID: 15741183; PMCID: PMC552952.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    43. Comparisons of substitution, insertion and deletion probes for resequencing and mutational analysis using oligonucleotide microarrays. Nucleic Acids Res. 2005 Feb 18; 33(3):e33. Karaman MW, Groshen S, Lee CC, Pike BL, Hacia JG. PMID: 15722479; PMCID: PMC549431.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    44. Gene expression profiling of glucocorticoid-inhibited osteoblasts. J Mol Endocrinol. 2004 Aug; 33(1):175-93. Leclerc N, Luppen CA, Ho VV, Nagpal S, Hacia JG, Smith E, Frenkel B. PMID: 15291752.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    45. The MLH1 D132H variant is associated with susceptibility to sporadic colorectal cancer. Nat Genet. 2004 Jul; 36(7):694-9. Lipkin SM, Rozek LS, Rennert G, Yang W, Chen PC, Hacia J, Hunt N, Shin B, Fodor S, Kokoris M, Greenson JK, Fearon E, Lynch H, Collins F, Gruber SB. PMID: 15184898.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    46. Improving the sensitivity and specificity of gene expression analysis in highly related organisms through the use of electronic masks. Nucleic Acids Res. 2004 Mar 18; 32(5):e51. Nagpal S, Karaman MW, Timmerman MM, Ho VV, Pike BL, Hacia JG. PMID: 15031318; PMCID: PMC390348.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    47. Comparative analysis of gene-expression patterns in human and African great ape cultured fibroblasts. Genome Res. 2003 Jul; 13(7):1619-30. Karaman MW, Houck ML, Chemnick LG, Nagpal S, Chawannakul D, Sudano D, Pike BL, Ho VV, Ryder OA, Hacia JG. PMID: 12840040; PMCID: PMC403735.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    48. Select your words carefully. Heredity (Edinb). 2003 May; 90(5):343-4. Hacia JG, Hey J. PMID: 12714975.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    49. Oligonucleotide microarrays demonstrate the highest frequency of ATM mutations in the mantle cell subtype of lymphoma. Proc Natl Acad Sci U S A. 2003 Apr 29; 100(9):5372-7. Fang NY, Greiner TC, Weisenburger DD, Chan WC, Vose JM, Smith LM, Armitage JO, Mayer RA, Pike BL, Collins FS, Hacia JG. PMID: 12697903; PMCID: PMC154352.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    50. Molecular pathology of head and neck cancer. Histol Histopathol. 2002; 17(3):909-14. Crowe DL, Hacia JG, Hsieh CL, Sinha UK, Rice H. PMID: 12168802.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    51. Genome of the apes. Trends Genet. 2001 Nov; 17(11):637-45. Hacia JG. PMID: 11672864.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    52. Oligonucleotide microarray based detection of repetitive sequence changes. Hum Mutat. 2000 Oct; 16(4):354-63. Hacia JG, Edgemon K, Fang N, Mayer RA, Sudano D, Hunt N, Collins FS. PMID: 11013446.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    53. Design of modified oligodeoxyribonucleotide probes to detect telomere repeat sequences in FISH assays. Nucleic Acids Res. 1999 Oct 15; 27(20):4034-9. Hacia JG, Novotny EA, Mayer RA, Woski SA, Ashlock MA, Collins FS. PMID: 10497268; PMCID: PMC148671.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    54. Mutational analysis using oligonucleotide microarrays. J Med Genet. 1999 Oct; 36(10):730-6. Hacia JG, Collins FS. PMID: 10528850; PMCID: PMC1734240.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    55. Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonucleotide arrays. Nat Genet. 1999 Jun; 22(2):164-7. Hacia JG, Fan JB, Ryder O, Jin L, Edgemon K, Ghandour G, Mayer RA, Sun B, Hsie L, Robbins CM, Brody LC, Wang D, Lander ES, Lipshutz R, Fodor SP, Collins FS. PMID: 10369258.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimals
    56. Resequencing and mutational analysis using oligonucleotide microarrays. Nat Genet. 1999 Jan; 21(1 Suppl):42-7. Hacia JG. PMID: 9915500.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimals
    57. Strategies for mutational analysis of the large multiexon ATM gene using high-density oligonucleotide arrays. Genome Res. 1998 Dec; 8(12):1245-58. Hacia JG, Sun B, Hunt N, Edgemon K, Mosbrook D, Robbins C, Fodor SP, Tagle DA, Collins FS. PMID: 9872980.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    58. Applications of DNA chips for genomic analysis. Mol Psychiatry. 1998 Nov; 3(6):483-92. Hacia JG, Brody LC, Collins FS. PMID: 9857973.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    59. Enhanced high density oligonucleotide array-based sequence analysis using modified nucleoside triphosphates. Nucleic Acids Res. 1998 Nov 01; 26(21):4975-82. Hacia JG, Woski SA, Fidanza J, Edgemon K, Hunt N, McGall G, Fodor SP, Collins FS. PMID: 9776762; PMCID: PMC147927.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    60. Two color hybridization analysis using high density oligonucleotide arrays and energy transfer dyes. Nucleic Acids Res. 1998 Aug 15; 26(16):3865-6. Hacia JG, Edgemon K, Sun B, Stern D, Fodor SP, Collins FS. PMID: 9685507; PMCID: PMC147769.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    61. New approaches to BRCA1 mutation detection. Breast Dis. 1998 Apr; 10(1-2):45-59. Hacia JG, Brody LC, Collins FS. PMID: 15687548.
      View in: PubMed   Mentions:    Fields:    
    62. Structure of a stereoregular phosphorothioate DNA/RNA duplex. Nat Struct Biol. 1998 Apr; 5(4):271-6. Bachelin M, Hessler G, Kurz G, Hacia JG, Dervan PB, Kessler H. PMID: 9546216.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    63. Evolutionary sequence comparisons using high-density oligonucleotide arrays. Nat Genet. 1998 Feb; 18(2):155-8. Hacia JG, Makalowski W, Edgemon K, Erdos MR, Robbins CM, Fodor SP, Brody LC, Collins FS. PMID: 9462745.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    64. Detection of heterozygous mutations in BRCA1 using high density oligonucleotide arrays and two-colour fluorescence analysis. Nat Genet. 1996 Dec; 14(4):441-7. Hacia JG, Brody LC, Chee MS, Fodor SP, Collins FS. PMID: 8944024.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    65. Inhibition of Klenow fragment DNA polymerase on double-helical templates by oligonucleotide-directed triple-helix formation. Biochemistry. 1994 May 24; 33(20):6192-200. Hacia JG, Dervan PB, Wold BJ. PMID: 8193133.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    66. Phosphorothioate oligonucleotide-directed triple helix formation. Biochemistry. 1994 May 10; 33(18):5367-9. Hacia JG, Wold BJ, Dervan PB. PMID: 8180158.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    67. Overproduction of a selenocysteine-containing polypeptide in Escherichia coli: the fdhF gene product. Mol Microbiol. 1992 Mar; 6(6):781-5. Chen GT, Axley MJ, Hacia J, Inouye M. PMID: 1533438.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
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