translocator

Upon ligand binding, the AHR translocates to the nucleus, where it complexes with the AHR nuclear translocator (ARNT).

The CGA approach may be limited because of probe selection in the Affymetrix Styl array.Among 498 SNPs associated with candidate genes, only 9 were located within exons {CYPJA2, ARNT2 (aryl-hydrocarbon receptor nuclear translocator 2), EPHX1 [epoxide hydrolase 1, microsomal (xenobiotic)], EPHX2, CYP26B1, GSTM3 (glutathione S-transferase mu 3 (brain)], and CYP4B11 and 87 were located within introns.

Most TCDD effects are mediated by its binding to the awl hydrocarbon receptor (AhR), leading to AhR nuclear translocation, heterodimerization with aryl hydrocarbon receptor nuclear translocator (ARNT), and binding to xenobiotic responsive elements present in the promoters of target genes (Barouki et al.

As a member of the PER-ARNT-SIM (PAS) domain family of transcriptional regulators, ligand-activated AhR translocates to the nucleus and heterodimerizes with AhR nuclear translocator (ARNT), leading to toxic responses (Bock 1994).

Because AHR associates with proteasomal complexes consisting of damaged-DNA-binding protein 1, aryl hydrocarbon receptor nuclear translocator, transducin-[beta]-like 3, and cullin 4B and itself possesses E3 ligase activity (Ohtake et al.

Binding of TCDD to AHR causes the dissociation of the receptor from the complex and its translocation into the nucleus, where it dimerizes with the AHR nuclear translocator (ARNT).

Dioxin and the structurally related PCDF chemicals mediate their toxic effect (but with different potencies) mainly as a ligand to the same aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT) complex that binds to the xenobiotic responsive element (XRE; also called dioxin-responsive element, DRE) on target DNA.