ceramidase


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ceramidase

 [sĕ-ram´ĭ-dās]
an enzyme occurring in most mammalian tissue that catalyzes the reversible acylation (incorporation of an acid radical) and deacylation (loss of an acid radical) in ceramides.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

cer·am·i·dase

(ser-am'i-dās),
An enzyme that hydrolyzes ceramides into sphingosine and a fatty acid; acylsphingosine deacylase. A deficiency of this enzyme is associated with disseminated lepogranulomatosis.
Farlex Partner Medical Dictionary © Farlex 2012

cer·am·i·dase

(sĕr-am'i-dās)
An enzyme that hydrolyzes ceramides into sphingosine and a fatty acid. A deficiency of this enzyme is associated with disseminated lipogranulomatosis.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
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References in periodicals archive ?
In conjunction, RVT-801 is a recombinant form of human acid ceramidase (rhAC) being developed as a potential enzyme replacement therapy for acid ceramidase deficiency, manifesting as Farber disease.
Enzyvant wins US FDA's Fast Track and Rare Pediatric Disease designations for Farber Disease Enzyme Replacement Therapy, RVT-801
Enzyvant, a subsidiary of Roivant Sciences, has selected Avid Bioservices as the commercial drug substance manufacturer for RVT801, its recombinant human acid ceramidase enzyme replacement therapy being developed as a potential treatment for Farber disease.
Enzyvant Selects Avid To Manufacture RVT-801
In an in vitro study, overexpression of acid ceramidase protected murine fibroblasts from TNF[alpha]induced cell apoptosis by shifting elevated ceramide towards cell survival sphingosine-1-phosphate [31].
Ceramide and Ischemia/Reperfusion Injury
El Bawab, "Bimodal effect of advanced glycation end products on mesangial cell proliferation is mediated by neutral ceramidase regulation and endogenous sphingolipids," The Journal of Biological Chemistry, vol.
Guiding the Differentiation Direction of Pancreatic Islet-Derived Stem Cells by Glycated Collagen
Necrosome activation also favors ceramide production through the induction of the ceramidase enzyme, and it promotes cytosolic calcium increase.
Pancreatic Beta Cell Death: Novel Potential Mechanisms in Diabetes Therapy
Wang et al., "Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin," Nature Medicine, vol.
Role of Adiponectin in Central Nervous System Disorders
Liu, IRF8 Regulates Acid Ceramidase Expression to Mediate Apoptosis and Suppresses Myelogeneous Leukemia, J.
The New Developments of Cantharidin and Its Analogues
In addition, inhibition of acid ceramidase with ceranib-2 has been reported to lead to apoptotic cell death in 5RP7 cells (Vejselova et al., 2014), LNCaP prostate cancer cells (Kus et al., 2015), melanoma (Proksch et al., 2011) and hepatomas (Osawa et al., 2005).
Comparative Study on Induction of Apoptosis in A549 Human Lung Adenocarcinoma Cells by C2 Ceramide or Ceranib-2
Acer2 (alkaline ceramidase 2) regulates the hydrolysis of ceramides.
Effect of Gegen Qinlian Decoction on Cardiac Gene Expression in Diabetic Mice

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