It can be seen that the compound I, which is a
benzoyl derivative exhibit a higher pKa value compared to the sulfonyl derivatives (compound II and III).
Leyden et al.19 conducted a study to determine the efficacy and safety of a combination
benzoyl peroxide plus clindamycin in a gel formulation compared with each of its 2 active constituents in gel vehicle, and gel vehicle given alone in the treatment of acne vulgaris.
acetyl, mesyl,
benzoyl, etc) play an important role as common denominator for various biological activities, which is also revealed by a number of our previous works [911].
Treatment with
benzoyl peroxide in combination with a retinoid has been recommended as a first-line treatment for women with acne, and the fixed-dose A-BPO combination used in this study has been shown to be safe in patients as young as age 9 years.
Subjects applied the OTC
benzoyl peroxide with lipohydroxy acid or the prescription
benzoyl peroxide and clindamycin twice daily for 12 weeks.
DISCUSSION: International guidelines for management of acne vulgaris recommend topical agents;
benzoyl peroxide, antibiotics, retinoids, etc as first-line treatment of acne vulgaris.
Scientists found that hydrogen peroxide-bleached liquid whey and whey protein concentrate contained higher concentrations of oxidation reaction products, including heptanal, hexanal, octanal and nonanal, compared with unbleached or
benzoyl peroxide-bleached liquid whey or whey protein concentrate.
Step 1 is using the Renewing Cleanser, a unique, oil-free formulated acne cleanser with smooth, tiny beads that exfoliate dead skin cells and other impurities, with deep-cleaning, prescription-grade
benzoyl peroxide, a grade not available in store-bought brands.
The conventional routes for synthesis of
benzoyl metronidazole were the two-step synthesis as shown in Scheme 1, which required the preparation of
benzoyl chloride; the reaction required strict anhydrous conditions [3, 4], and the reactor should be corrosion resistant.
Jan Marini's
Benzoyl Peroxide Acne Wash (pounds 30.10, www.amazon.co.uk) comes highly
Benzoyl peroxide in particular is effective because there is little to no antibacterial resistance, whereas there may be resistance with the other two.