"This may potentially be due to loss of
progenitor cells. Once mutations in exosome complex genes are identified in either skin diseases or other diseases like pontocerebellar hypoplasia, it may be possible to design drugs targeting these defects," he added.
Biotechnology company BioTime Inc (NYSE Amex:BTIM) reported on Thursday that the company will launch seven new human embryonic
progenitor cell lines with seven corresponding novel culture media on 1 September 2010.
Further understanding of the relationship between oxidative damage and EPC function will lead to future antioxidant treatments, and EPCs may become "a method to evaluate the effectiveness of interventions to reduce vascular morbidities and mortalities." (1) One of resveratrol's multiple benefits is its ability to upregulate endothelial
progenitor cells. (2)
The brains of the pups from those mothers had 20 percent fewer oligodendrocyte
progenitor cells than did brains from pups of untreated mothers, the team reports in the February PLoS Biology.
The general view in the field has been that there is a limited number of
progenitor cells that are formed during embryonic development and then consumed for bone growth until they run out and we stop growing.
The approach, based on discoveries in
progenitor cell biology from the labs of Bob Langer, Sc.D., at MIT and Jeff Karp, Ph.D., at Harvard Medical School and Brigham and Women's Hospital, utilises small molecules to awaken dormant
progenitor cells already in the body and has the opportunity to address numerous degenerative diseases such as hearing loss, demyelinating diseases, skin disorders and gastrointestinal conditions.
Ren Gong et al., "Endothelial
progenitor cells in atherosclerosis," Frontiers in Bioscience (Landmark Ed), vol.
These neurons are generated by
progenitor cells, which produce them one after the other in a very precise order.
Research previously showed that the numbers of
progenitor cells are also diminished in organs that shrink with age.
Frequency is pioneering a new class of small-molecule therapeutics designed to activate
progenitor cells already present within the body to create healthy functional tissues and organs.
Building on previous research by Nakano, which showed that the embryonic heart tube produces blood
progenitor cells, the new study found that those cells, in turn, generate specialized immune cells called macrophages.
Injecting patients with stem cells (
progenitor cells) engineered to repair the central nervous system could become the first treatment to repair spinal cords inflamed by transverse myelitis.