2, said the team has found the novel role of Galectin-3 (
Gal3) in promoting microglia-mediated neuroinflammation -- which subsequently worsens neurodegenerative disorders like Huntington's disease and Alzheimer's.
This study showed that Galectin-3 (
Gal3), an inflammatory cytokine secreted by macrophages, can bind to insulin receptors and interfere with related signaling pathways, resulting in insulin resistance.
(c) Percentage of infection and (d) number of parasites per cell in J774 macrophages nontransduced (WT) or transduced with control vector (Ctrl) or Gal-3 shRNA (
Gal3 KD).
B)
Gal3 immunulocalization of tertiary follicles in control group (*).
The distribution of Axin rs214250,
Gal3 rs4644 and
Gal3 rs4652 alleles in patients and controls Genotypes and Patients n(%) Controls n(%) p-value alleles Axin rs214250 CC 74 (62.2) 77 (65.8) 0.260 CT 33 (27.7) 23 (19.7) TT 12 (10.1) 17 (14.5) C allele 181 (76.1) 177 (75.6) 0.917 T allele 57 (23.9) 57 (24.4)
Gal3 rs4644 CC 62 (52.1) 61 (52.1) 0.026 CA 52 (43.7) 40 (34.2) AA 5 (4.2) 16 (13.7) C allele 176 (74) 162 (69.2) 0.25 A allele 62 (26) 72 (30.8)
Gal3 rs4652 AA 46 (38.7) 48 (41) 0.039 AC 65 (54.6) 50 (42.7) CC 8 (6.7) 19 (16.2) A allele 157 (66) 146 (62.4) 0.418 C allele 81 (34) 88 (37.6) TABLE 4.
(93-99) Among the variety of biomarkers reported in the literature, Hector Battifora mesothelial-1 (HBME-1), galectin-3 (
GAL3), cytokeratin 19 (CK19), Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain, 1 (CITED1), and TPO are most promising.
This panel consisted of
GAL3, PAK2, PHB2, RACK1, and RUVBL1.
Gal3: Those who are of faith are blessed with Abraham.