CD15

a phosphatidylinositol-anchored transmembrane protein found on neutrophils; it may be involved in phagocytosis; expressed in patients with Hodgkin disease, some B-cell chronic lymphocytic leukemias, acute lymphoblastic leukemias, and most acute nonlymphocytic leukemias.

Farlex Partner Medical Dictionary © Farlex 2012

CD15

This is a retired HUGO symbol for what molecular biologists now term FUT4 (see there). In practice, CD15 is widely used by haematologists, immunologists, laboratorians, pathologists and many others.

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References in periodicals archive ?

Conversely, CD15 was positive in 88% of cHL cases that were negative for CD137.

Validation of CD137 Immunohistochemical Stain on Paraffin-Embedded Tissue as a Marker to Facilitate Distinction Between Classic Hodgkin Lymphoma, Nodular Lymphocyte--Predominant Hodgkin Lymphoma, T-Cell/Histiocyte-Rich Large B-Cell Lymphoma, and Anaplastic Large Cell Lymphoma

(A) Genome browser view displays tracks from top: Refseq gene AHRR; CpG Islands; C14+ Monocyte DMRs (black bar); differentially methylated CpGs ([DELTA] Methylation %) in CD14+ monocytes (CD14+ Mono) and CD15 + granulocytes (CD15 + Gran), and histone modification data tracks from the Epigenome Roadmap Project(a) for each cell type: H3K4me3, histone H3 Lysine 4 trimethyl (active mark); H3K27ac, histone H3 Lysine 27acetyl (active enhancer); H3K4me1, histone H3 Lysine 4 monomethyl (enhancer); H3K27me3, histone H3 Lysine 27trimethyl (repressive mark).

Identification of Smoking-Associated Differentially Methylated Regions Using Reduced Representation Bisulfite Sequencing and Cell type-Specific Enhancer Activation and Gene Expression

(a) mRNA expression of eight stem cell markers (Nestin, CXCR4, Oct3/4, CD15, CD133, Bmi-1, Sox2, and CD44) and four stem cell-related molecules (HIF-1[alpha], HIF-2[alpha], VEGF, and TGF-[beta]) in the core and the periphery was determined with qRT-PCR.

Significance of Glioma Stem-Like Cells in the Tumor Periphery That Express High Levels of CD44 in Tumor Invasion, Early Progression, and Poor Prognosis in Glioblastoma

(3-5,7) In the present case the HRS cells were CD30+, CD20+, CD79a+ but CD15 was negative as may occur in these lymphomas.

Prolonged lymphocytosis as the first manifestation of Hodgkin-like adult T-cell leukemia/lymphoma

Interestingly, besides an increase in neutrophil number, as seen in experimental data from hypercortisolemic conditions [27, 28], the neutrophils of all CS patients showed a tendency to express activation markers like FC receptor CD16 and tetrasaccharide adhesion marker CD15, an association that persists in multiregression analysis.

Circulatory Immune Cells in Cushing Syndrome: Bystanders or Active Contributors to Atherometabolic Injury? A Study of Adhesion and Activation of Cell Surface Markers

Bone marrow biopsy and aspirate showed 73% myeloblasts and immature promonocytes expressing CD13, CD15, CD33, CD45, CD64, CD123, and HLA-DR by immunohistochemistry (IHC) and flow cytometry (FC).

Spontaneous Remission in an Older Patient with Relapsed FLT3 ITD Mutant AML

Reed- Sternberg-like and histiocyte-like cells displayed CD68 (Figure 1D) and Mac387 expression; however, no reaction was determined with CD15 (LeuM1) and CD30 (Ki-1).

T-cell/histiocyte-rich large B-cell lymphoma of stomach

Pericardial biopsy revealed multiple nodules with interstitial hyalineosis containing a polymorphic infiltrate of small lymphocytes, rare eosinophils and Reed-Sternberg cells with CD30 and CD15 positivity (Figure 2).

Classical nodular sclerosis Hodgkin lymphoma presenting with atypical cardiac involvement

strain cd15 isolated from the tissue of coral Goniastrea aspera, jepara waters.

Evaluation of Cadmium Resistant Bacterium, Klebsiella pneumoniae, Isolated from Industrial Wastewater for its Potential Use to Bioremediate Environmental Cadmium

All cases of lymphoma were CD20 positive, CD5, CD15, and CD30 negative and the patients were diagnosed with diffuse large B-cell lymphoma [Table 3].

Spectrum of sinonasal tumors: a 10-year experience at a tertiary care hospital in North India

The panel of lymphoid antibodies included: TdT, CD34, CD45, CD19,CD20, CD79, MUM-1 CDI0 ,CD21, CD23, CD3 ,CD4, CD5, CD8, CD15, CD30, CD43, CD56,CD68, MPO, Ki-67, Bcl-2, Bcl-6, Cyclin D1, Kappa, Lamda, ALK-1, ZAP 17 were used.