ARID2

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ARID2

A gene on chromosome12q12 that encodes as protein involved in transcriptional activation and repression of select genes by chromatin remodelling (by altering DNA-nucleosome topology). ARID2 is required for stabilising the SWI/SNF chromatin remodelling complex SWI/SNF-B (PBAF); it may play a role in targeting the complex to different genes, and may be involved in regulating transcriptional activation of cardiac genes. ARID2 is highly expressed in the heart and testes.

References in periodicals archive ?

Zhang et al., "Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma," Nature Genetics, vol.

Whole-Exome Sequencing-Based Mutational Profiling of Hepatitis B Virus-Related Early-Stage Hepatocellular Carcinoma

(34) In addition, mutations in the switch/ sucrose nonfermentable family of chromatin-remodeling genes ARIDlA, SMARCA4, and ARID2 also occur in about 20% of microsatellite-stable EACs, supporting the role of ARIDlA as an independent tumor-suppressor pathway in esophageal carcinogenesis.

Morphological Features and Prognostic Significance of ARIDIA-Deficient Esophageal Adenocarcinomas

Some of the mutated genes that have been identified in pancreatic cancer and have been added to clinical testing panels include MLL3, TGFBR2, ARID1A, SF3B1, ATM, and ARID2. (38) The GATA4 gene product was found to be overexpressed by immunohisto-chemical testing of pancreatic ductal adenocarcinoma.

The Cancer Genomics Resource List 2014

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