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Exploration of nature's chemodiversity: the role of secondary metabolites as leads in drug development

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Exploration of nature's chemodiversity: the role of secondary metabolites as leads in drug development (English)

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Rob Verpoorte

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publication date

May 1998

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published in

Drug Discovery Today

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volume

3

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issue

5

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page(s)

232-238

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cites work

The Future of Biodiversity

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Combinatorial chemistry in drug discovery

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Natural product drug discovery and development: new perspectives on international collaboration

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Developmental Regulation of Alkaloid Production in Cinchona Seedlings

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Control and biological implications of alkaloid synthesis inCinchona seedlings

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The distribution of strictosidine-synthase activity and alkaloids in Cinchona plants

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Detrimental effects ofCinchona leaf alkaloids on larvae of the polyphagous insectSpodoptera exigua.

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Antimicrobial and antifungal activities of quasi-dimeric and related alkaloids

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Preformed Antimicrobial Compounds and Plant Defense against Fungal Attack

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Subcellular localization of tryptophan decarboxylase, strictosidine synthase and strictosidine glucosidase in suspension cultured cells of Catharanthus roseus and Tabernaemontana divaricata

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Chapter 3 Biosynthesis of Terpenoid Indole Alkaloids in Catharanthus roseus Cells

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Involvement of strictosidine as a defensive chemical inCatharanthus roseus

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Airborne signalling by methyl salicylate in plant pathogen resistance

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Anthraquinones as phytoalexins in cell and tissue cultures of Cinchona spec.

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The role of primary and secondary metabolites in chrysanthemum resistance toFrankliniella occidentalis

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Synergistic interaction between potato glycoalkaloidsα-solanine andα-chaconine in relation to destabilization of cell membranes: Ecological implications.

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Polyketide synthase gene manipulation: a structure-function approach in engineering novel antibiotics

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DOI

10.1016/S1359-6446(97)01167-7

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(Q57058428)

Exploration of nature's chemodiversity: the role of secondary metabolites as leads in drug development

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