(Q44642043)

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Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding.

scientific article published on 3 November 2003

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20 December 2019

Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding (English)

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20 December 2019

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20 December 2019

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20 December 2019

Jonathan Javitch

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20 December 2019

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Charlotta Grånäs

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20 December 2019

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3 November 2003

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20 December 2019

Journal of Biological Chemistry

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20 December 2019

279

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20 December 2019

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20 December 2019

3228-3238

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20 December 2019

Neurotransmitter transporters: recent progress

1 reference

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21 January 2018

Biogenic amine transporters: regulation in flux

1 reference

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21 January 2018

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

1 reference

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Monoamine transporters: from genes to behavior

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Structure and function of the dopamine transporter

1 reference

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21 January 2018

Delineation of an endogenous zinc-binding site in the human dopamine transporter

1 reference

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21 January 2018

Defining proximity relationships in the tertiary structure of the dopamine transporter. Identification of a conserved glutamic acid as a third coordinate in the endogenous Zn(2+)-binding site.

1 reference

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21 January 2018

Symmetrical dimer of the human dopamine transporter revealed by cross-linking Cys-306 at the extracellular end of the sixth transmembrane segment

1 reference

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21 January 2018

Oligomerization of serotonin transporter and its functional consequences

1 reference

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21 January 2018

Oligomerization of the human serotonin transporter and of the rat GABA transporter 1 visualized by fluorescence resonance energy transfer microscopy in living cells.

1 reference

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21 January 2018

Zn(2+) site engineering at the oligomeric interface of the dopamine transporter.

1 reference

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21 January 2018

Cocaine alters the accessibility of endogenous cysteines in putative extracellular and intracellular loops of the human dopamine transporter.

1 reference

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21 January 2018

Transport-dependent accessibility of a cytoplasmic loop cysteine in the human dopamine transporter

1 reference

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21 January 2018

Permeation and gating residues in serotonin transporter

1 reference

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21 January 2018

A conformationally sensitive residue on the cytoplasmic surface of serotonin transporter

1 reference

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21 January 2018

Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle

1 reference

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21 January 2018

Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism

1 reference

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21 January 2018

Biosynthesis of peptide precursors and protease inhibitors using new constitutive and inducible eukaryotic expression vectors.

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21 January 2018

Stable expression of high affinity NK1 (substance P) and NK2 (neurokinin A) receptors but low affinity NK3 (neurokinin B) receptors in transfected CHO cells

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21 January 2018

N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization.

1 reference

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21 January 2018

Oligomerization and trafficking of the human dopamine transporter. Mutational analysis identifies critical domains important for the functional expression of the transporter

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21 January 2018

Preservation and staining of myelinated nerve fibers

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21 January 2018

The role of conserved tryptophan and acidic residues in the human dopamine transporter as characterized by site-directed mutagenesis

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21 January 2018

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

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21 January 2018

Uncovering molecular mechanisms involved in activation of G protein-coupled receptors

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21 January 2018

The uptake inhibitors cocaine and benztropine differentially alter the conformation of the human dopamine transporter

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21 January 2018

Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism

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21 January 2018

Cocaine affinity decreased by mutations of aromatic residue phenylalanine 105 in the transmembrane domain 2 of dopamine transporter

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21 January 2018

Novel tropane-based irreversible ligands for the dopamine transporter

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21 January 2018

Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

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21 January 2018

Residues in the extracellular loop 4 are critical for maintaining the conformational equilibrium of the gamma-aminobutyric acid transporter-1.

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21 January 2018

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10.1074/JBC.M304755200

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14597628%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14597628%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

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