(Q37802193)

23 August 2017

title

The FERM domain: organizing the structure and function of FAK. (English)

1 reference

23 August 2017

Daniel Lietha

4

0 references

Margaret Frame

object named as

Margaret C Frame

series ordinal

1

0 references

Bryan Serrels

series ordinal

3

object named as

Bryan Serrels

1 reference

23 August 2017

Hitesh Patel

2

1 reference

23 August 2017

Michael J Eck

series ordinal

5

1 reference

23 August 2017

publication date

1 November 2010

1 reference

Nature Reviews Molecular Cell Biology

23 August 2017

published in

1 reference

23 August 2017

volume

11

1 reference

23 August 2017

issue

11

1 reference

23 August 2017

page(s)

802-814

1 reference

The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane

23 August 2017

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31 March 2020

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FAK integrates growth-factor and integrin signals to promote cell migration

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Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex

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31 March 2020

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Regulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interaction

31 March 2020

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A truncated FAK lacking the FERM domain displays high catalytic activity but retains responsiveness to adhesion-mediated signals

31 March 2020

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Spatial and temporal regulation of focal adhesion kinase activity in living cells.

31 March 2020

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Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain

31 March 2020

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Dynamic conformational changes in the FERM domain of FAK are involved in focal-adhesion behavior during cell spreading and motility.

31 March 2020

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31 March 2020

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31 March 2020

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The structure, regulation, and function of ZAP-70.

31 March 2020

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Structural basis for the inhibition of tyrosine kinase activity of ZAP-70

31 March 2020

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Movin' on up: the role of PtdIns(4,5)P(2) in cell migration.

31 March 2020

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A conspicuous connection: structure defines function for the phosphatidylinositol-phosphate kinase family.

31 March 2020

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Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions

31 March 2020

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Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin

31 March 2020

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Tyrosine phosphorylation of type Igamma phosphatidylinositol phosphate kinase by Src regulates an integrin-talin switch

31 March 2020

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Structural basis for phosphatidylinositol phosphate kinase type Igamma binding to talin at focal adhesions

31 March 2020

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Structural basis for the phosphorylation-regulated focal adhesion targeting of type Igamma phosphatidylinositol phosphate kinase (PIPKIgamma) by talin

31 March 2020

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Type I gamma phosphatidylinositol phosphate kinase is required for EGF-stimulated directional cell migration

31 March 2020

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Association of beta 1 integrin with focal adhesion kinase and paxillin in differentiating Schwann cells.

31 March 2020

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Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains

31 March 2020

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Regulation of focal adhesion kinase by a novel protein inhibitor FIP200

31 March 2020

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EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas).

31 March 2020

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Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation

31 March 2020

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Protein-tyrosine phosphatase PTPD1 regulates focal adhesion kinase autophosphorylation and cell migration.

31 March 2020

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31 March 2020

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Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition

31 March 2020

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Direct Interaction of Focal Adhesion Kinase with p190RhoGEF

31 March 2020

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An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase

31 March 2020

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The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly

31 March 2020

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Focal adhesion kinase regulation of N-WASP subcellular localization and function

31 March 2020

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Autophosphorylation-independent and -dependent functions of focal adhesion kinase during development

31 March 2020

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Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation.

31 March 2020

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Residues within the first subdomain of the FERM-like domain in focal adhesion kinase are important in its regulation.

31 March 2020

1 reference

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A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity

31 March 2020

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Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.

31 March 2020

1 reference

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Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression

31 March 2020

1 reference

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Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase

31 March 2020

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SRC-3Delta4 mediates the interaction of EGFR with FAK to promote cell migration

31 March 2020

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Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain

31 March 2020

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31 March 2020

Integrins and anoikis

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Clinging to life: cell to matrix adhesion and cell survival

31 March 2020

1 reference

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Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

31 March 2020

1 reference

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Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis.

31 March 2020

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Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation

31 March 2020

1 reference

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The 7-amino-acid site in the proline-rich region of the N-terminal domain of p53 is involved in the interaction with FAK and is critical for p53 functioning

31 March 2020

1 reference

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Role of focal adhesion kinase Ser-732 phosphorylation in centrosome function during mitosis

31 March 2020

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Paxillin nuclear-cytoplasmic localization is regulated by phosphorylation of the LD4 motif: evidence that nuclear paxillin promotes cell proliferation

31 March 2020

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Nuclear translocation of Xenopus laevis paxillin

31 March 2020

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Zyxin and paxillin proteins: focal adhesion plaque LIM domain proteins go nuclear

31 March 2020

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ERM proteins and merlin: integrators at the cell cortex

31 March 2020

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The N-termini of FAK and JAKs contain divergent band 4.1 domains

31 March 2020

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FERM domain interaction promotes FAK signaling

31 March 2020

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The N termini of focal adhesion kinase family members regulate substrate phosphorylation, localization, and cell morphology

31 March 2020

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Protein-tyrosine kinase CAKbeta/PYK2 is activated by binding Ca2+/calmodulin to FERM F2 alpha2 helix and thus forming its dimer

31 March 2020

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Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival

31 March 2020

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The role of FAS to ezrin association in FAS-mediated apoptosis

31 March 2020

1 reference

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Sisyphus, the Drosophila myosin XV homolog, traffics within filopodia transporting key sensory and adhesion cargos

31 March 2020

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A microtubule-binding myosin required for nuclear anchoring and spindle assembly.

31 March 2020

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Myosin-10 and actin filaments are essential for mitotic spindle function

31 March 2020

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Moesin controls cortical rigidity, cell rounding, and spindle morphogenesis during mitosis

31 March 2020

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Moesin and its activating kinase Slik are required for cortical stability and microtubule organization in mitotic cells

31 March 2020

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Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus

31 March 2020

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Kindlins in FERM adhesion.

31 March 2020

1 reference

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Two mutations in the KINDLIN3 gene of a new leukocyte adhesion deficiency III patient reveal distinct effects on leukocyte function in vitro

31 March 2020

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The Kindlin protein family: new members to the club of focal adhesion proteins

31 March 2020

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Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction

31 March 2020

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Migfilin and its binding partners: from cell biology to human diseases

31 March 2020

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Colocalization of kindlin-1, kindlin-2, and migfilin at keratinocyte focal adhesion and relevance to the pathophysiology of Kindler syndrome.

31 March 2020

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Expression of the mitogen-inducible gene-2 (mig-2) is elevated in human uterine leiomyomas but not in leiomyosarcomas.

31 March 2020

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Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271

31 March 2020

1 reference

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Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models

31 March 2020

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The signaling and biological implications of FAK overexpression in cancer

31 March 2020

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Anti-VEGF aptamer (pegaptanib) therapy for ocular vascular diseases

31 March 2020

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Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease

31 March 2020

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Critical role of the FERM domain in Pyk2 stimulated glioma cell migration

31 March 2020

1 reference

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Structural conservation in band 4.1, ezrin, radixin, moesin (FERM) domains as a guide to identify inhibitors of the proline-rich tyrosine kinase 2.

31 March 2020

1 reference

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A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM2996

Ezrin interacts with focal adhesion kinase and induces its activation independently of cell-matrix adhesion

31 March 2020

1 reference

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Insulin receptor substrate-1 as a signaling molecule for focal adhesion kinase pp125(FAK) and pp60(src)

31 March 2020

1 reference

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A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated

31 March 2020

1 reference

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Two-color photoactivatable probe for selective tracking of proteins and cells

31 March 2020

1 reference

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Nuclear ERM (ezrin, radixin, moesin) proteins: regulation by cell density and nuclear import

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM2996

Nucleocytoplasmic transfer of the NF2 tumor suppressor protein merlin is regulated by exon 2 and a CRM1-dependent nuclear export signal in exon 15.

31 March 2020

1 reference

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Cell cycle-dependent nucleocytoplasmic shuttling of the neurofibromatosis 2 tumour suppressor merlin.

31 March 2020

1 reference

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Talin concentrates to the midbody region during mammalian cell cytokinesis.

31 March 2020

1 reference

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Suppression of hepatitis B viral gene expression by protein-tyrosine phosphatase PTPN3.

31 March 2020

1 reference

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Subcellular localization and differentiation-induced redistribution of the protein tyrosine phosphatase PTP-BL in Neuroblastoma cells.

31 March 2020

1 reference

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Protein 4.1, a component of the erythrocyte membrane skeleton and its related homologue proteins forming the protein 4.1/FERM superfamily.

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20966971

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to the nucleus is associated with induction of cell proliferation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20966971

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRM2996

1 reference

Dimensions Publication ID

23 August 2017

1026995058

0 references

1 reference