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Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways.
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Europe PubMed Central
PMC publication ID
2863124
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11058076%20AND%20SRC:MED&resulttype=core&format=json
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1 November 2019
review article
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Europe PubMed Central
title
Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways
(English)
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Europe PubMed Central
PMC publication ID
2863124
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11058076%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
main subject
DNA damage
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author
Nicholas Rhind
series ordinal
1
1 reference
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Europe PubMed Central
PMC publication ID
2863124
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11058076%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
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P Russell
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2
1 reference
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Europe PubMed Central
PMC publication ID
2863124
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11058076%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
language of work or name
English
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publication date
1 November 2000
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Europe PubMed Central
PMC publication ID
2863124
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11058076%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
number of pages
8
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Journal of Cell Science
1 reference
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Europe PubMed Central
PMC publication ID
2863124
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11058076%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
volume
113 ( Pt 22)
1 reference
stated in
Europe PubMed Central
PMC publication ID
2863124
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11058076%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
page(s)
3889-3896
1 reference
stated in
Europe PubMed Central
PMC publication ID
2863124
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11058076%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
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The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01
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An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage
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The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
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Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
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Characterization of a Saccharomyces cerevisiae homologue of Schizosaccharomyces pombe Chk1 involved in DNA-damage-induced M-phase arrest
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Regulation of mitotic inhibitor Mik1 helps to enforce the DNA damage checkpoint
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DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis
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DNA replication checkpoint control
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Drosophila grapes/CHK1 mutants are defective in cyclin proteolysis and coordination of mitotic events
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RAD53, DUN1 and PDS1 define two parallel G2/M checkpoint pathways in budding yeast
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Basis for the checkpoint signal specificity that regulates Chk1 and Cds1 protein kinases
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The Pds1 anaphase inhibitor and Mec1 kinase define distinct checkpoints coupling S phase with mitosis in budding yeast
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Cdc25 inhibited in vivo and in vitro by checkpoint kinases Cds1 and Chk1
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Mitotic DNA damage and replication checkpoints in yeast
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4 July 2018
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
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Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
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A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication
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DNA damage checkpoint in budding yeast.
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4 July 2018
The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts
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4 July 2018
Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway
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4 July 2018
The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor
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4 July 2018
Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint
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4 July 2018
Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control
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4 July 2018
Tyrosine phosphorylation of cdc2 is required for the replication checkpoint in Schizosaccharomyces pombe
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4 July 2018
Replication checkpoint enforced by kinases Cds1 and Chk1.
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4 July 2018
C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding
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4 July 2018
S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe
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4 July 2018
The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway
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4 July 2018
Cell-cycle signaling: Atm displays its many talents
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4 July 2018
Rad53-dependent phosphorylation of Swi6 and down-regulation of CLN1 and CLN2 transcription occur in response to DNA damage in Saccharomyces cerevisiae
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4 July 2018
Maintaining genetic stability through TP53 mediated checkpoint control.
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4 July 2018
Control of S-phase periodic transcription in the fission yeast mitotic cycle
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4 July 2018
A dual-specificity phosphatase Cdc25B is an unstable protein and triggers p34(cdc2)/cyclin B activation in hamster BHK21 cells arrested with hydroxyurea.
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4 July 2018
Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216
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4 July 2018
Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25
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4 July 2018
DNA-replication checkpoint control at the Drosophila midblastula transition
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4 July 2018
The role of inhibitory phosphorylation of CDC2 following DNA replication block and radiation-induced damage in human cells
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4 July 2018
Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA
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4 July 2018
Inactivation of the cyclin-dependent kinase Cdc28 abrogates cell cycle arrest induced by DNA damage and disassembly of mitotic spindles in Saccharomyces cerevisiae
1 reference
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PubMed Central
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4 July 2018
Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation.
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PubMed Central
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4 July 2018
The Schizosaccharomyces pombe rad3 checkpoint gene
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4 July 2018
Cell cycle checkpoints: preventing an identity crisis
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4 July 2018
Spindle pole body separation in Saccharomyces cerevisiae requires dephosphorylation of the tyrosine 19 residue of Cdc28.
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4 July 2018
Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124
retrieved
4 July 2018
Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124
retrieved
4 July 2018
DUN1 encodes a protein kinase that controls the DNA damage response in yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124
retrieved
4 July 2018
Purification of a serine kinase that associates with and phosphorylates human Cdc25C on serine 216.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124
retrieved
4 July 2018
The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124
retrieved
4 July 2018
Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124
retrieved
4 July 2018
Cdc2 regulatory factors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124
retrieved
4 July 2018
Characterization of G1 checkpoint control in the yeast Saccharomyces cerevisiae following exposure to DNA-damaging agents
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124
retrieved
4 July 2018
A single ataxia telangiectasia gene with a product similar to PI-3 kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124
retrieved
4 July 2018
A cell cycle checkpoint monitors cell morphogenesis in budding yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124
retrieved
4 July 2018
DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124
retrieved
4 July 2018
ATM-related genes: What do they tell us about functions of the human gene?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124
retrieved
4 July 2018
The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124
retrieved
4 July 2018
Checkpoints: controls that ensure the order of cell cycle events
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124
retrieved
4 July 2018
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124
retrieved
4 July 2018
The Drosophila ATM homologue Mei-41 has an essential checkpoint function at the midblastula transition.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124
retrieved
29 October 2018
Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124
retrieved
29 October 2018
The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124
retrieved
29 October 2018
The Drosophila grapes gene is related to checkpoint gene chk1/rad27 and is required for late syncytial division fidelity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124
retrieved
29 October 2018
Protein phosphatase 2A regulates MPF activity and sister chromatid cohesion in budding yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124
retrieved
29 October 2018
rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124
retrieved
29 October 2018
A kinase from fission yeast responsible for blocking mitosis in S phase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124
retrieved
29 October 2018
The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124
retrieved
29 October 2018
Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/11058076
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Regulation of DNA-replication origins during cell-cycle progression
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/11058076
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/11058076
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/11058076
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A S/M DNA replication checkpoint prevents nuclear and cytoplasmic events of cell division including centrosomal axis alignment and inhibits activation of cyclin-dependent kinase-like proteins in fucoid zygotes
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/11058076
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Fission yeast wee1 protein kinase is not required for DMA damage-dependent mitotic arrest
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/11058076
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/11058076
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/11058076
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A DNA damage checkpoint meets the cell cycle engine
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/11058076
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
CDC5 and CKII control adaptation to the yeast DNA damage checkpoint
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/11058076
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
PMC publication ID
2863124
1 reference
stated in
Europe PubMed Central
PMC publication ID
2863124
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11058076%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
PubMed publication ID
11058076
1 reference
stated in
Europe PubMed Central
PMC publication ID
2863124
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11058076%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
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