(Q23911011)

English

An age-dependent physiologically based pharmacokinetic/pharmacodynamic model for the organophosphorus insecticide chlorpyrifos in the preweanling rat

journal article published in 2007

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scholarly article

1 reference

19 July 2017

An age-dependent physiologically based pharmacokinetic/pharmacodynamic model for the organophosphorus insecticide chlorpyrifos in the preweanling rat (English)

1 reference

12 July 2017

National Institute for Occupational Safety and Health

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2 references

19 July 2017

29 March 2020

1 reference

19 July 2017

exposure assessment

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19 July 2017

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1 reference

29 March 2020

1 reference

29 March 2020

pharmacodynamics

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based on heuristic

inferred from title

pharmacokinetics

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based on heuristic

inferred from title

author name string

C. Timchalk

1

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A. A. Kousba

2

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T. S. Poet

3

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language of work or name

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publication date

10 April 2007

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Toxicological Sciences

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98

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2

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348-365

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performing organization

Battelle Memorial Institute

object named as

Battelle Memorial Institute, Richland, Washington

1 reference

2 February 2024

on focus list of Wikimedia project

Wikimedia–NIOSH collaboration

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1 reference

25 September 2023

Maturational differences in chlorpyrifos-oxonase activity may contribute to age-related sensitivity to chlorpyrifos.

1 reference

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Tissue-specific effects of chlorpyrifos on carboxylesterase and cholinesterase activity in adult rats: an in vitro and in vivo comparison.

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Genetic polymorphisms in human drug metabolic enzymes

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Physiological-model-based derivation of the adult and child pharmacokinetic intraspecies uncertainty factors for volatile organic compounds

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Computer simulation of the lactational transfer of tetrachloroethylene in rats using a physiologically based model

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Age-related differences in parathion and chlorpyrifos toxicity in male rats: target and nontarget esterase sensitivity and cytochrome P450-mediated metabolism

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Age- and gender-related differences in the time course of behavioral and biochemical effects produced by oral chlorpyrifos in rats

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Kinetics of methylmercury and inorganic mercury in lactating and nonlactating mice

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Age-related changes in acetylcholinesterase and its molecular forms in various brain areas of rats

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Size and charge isomers of acetylcholinesterase in the cerebral cortex of young and aged rats

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AGE VARIATION IN PLASMA ARYLESTERASE ACTIVITY IN CHILDREN

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The influence of age on the toxicity and metabolism of methyl parathion and parathion in male and female rats

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Comparative toxicity of some selected pesticides in neonatal and adult rats

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Chlorpyrifos: Pharmacokinetics in human volunteers

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The effects of blood flow and detoxification on in vivo cholinesterase inhibition by soman in rats

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Physiologically based pharmacokinetic modeling of the lactating rat and nursing pup: a multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid.

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Physiologically based pharmacokinetic and pharmacodynamic model for the inhibition of acetylcholinesterase by diisopropylfluorophosphate

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Comparison of in vivo cholinesterase inhibition in neonatal and adult rats by three organophosphorothioate insecticides

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Age-dependent pharmacokinetic and pharmacodynamic response in preweanling rats following oral exposure to the organophosphorus insecticide chlorpyrifos

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Age-related effects of chlorpyrifos on acetylcholine release in rat brain

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Kinetic parameters of desulfuration and dearylation of parathion and chlorpyrifos by rat liver microsomes

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Rat brain acetylcholinesterase activity: developmental profile and maturational sensitivity to carbamate and organophosphorus inhibitors

1 reference

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Age-related differences in sensitivity to organophosphorus pesticides.

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Mammalian toxicology of organophosphorus pesticides.

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Changes in rat brain cholinesterase activity and muscarinic receptor density during and after repeated oral exposure to chlorpyrifos in early postnatal development.

1 reference

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Comparative cholinergic neurotoxicity of oral chlorpyrifos exposures in preweanling and adult rats.

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Effects of repeated oral postnatal exposure to chlorpyrifos on open-field behavior in juvenile rats.

1 reference

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A Physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model for the organophosphate insecticide chlorpyrifos in rats and humans

1 reference

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1 reference

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1 reference

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Comparison of chlorpyrifos-oxon and paraoxon acetylcholinesterase inhibition dynamics: potential role of a peripheral binding site

1 reference

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1 reference

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7 January 2021

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Age-related brain cholinesterase inhibition kinetics following in vitro incubation with chlorpyrifos-oxon and diazinon-oxon

1 reference

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1 reference

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1 reference

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COMPARISON OF ACUTE TOXICITY OF ANTICHOLINESTERASE INSECTICIDES TO WEANLING AND ADULT MALE RATS

1 reference

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Identifiers

10.1093/TOXSCI/KFM119

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release_vedos2wkqfeclocht4jnzlfhfa

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24 November 2022

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mapped directly with Wikidata item

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